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The impact of four years of semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: A community-based study in the Democratic Republic of the Congo.
PLoS Negl Trop Dis. 2020 06; 14(6):e0008322.PN

Abstract

BACKGROUND

The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs. However, the published evidence base to support this policy is thin, and uptake by national programs has been slow.

METHODOLOGY/PRINCIPAL FINDINGS

We conducted a community trial to assess the impact of semiannual MDA on lymphatic filariasis and soil-transmitted helminth infections (STH) in two villages in the Bandundu province of the Democratic Republic of the Congo with moderately high prevalences for LF and hookworm infections. MDA with albendazole was provided every six months from June 2014 to December 2017 with treatment coverages of the eligible population (all ≥ 2 year of age) that ranged between 56% and 88%. No adverse effects were reported during the trial. Evaluation at 48 months, (i.e. 6 months after the 8th round of MDA), showed that W. bancrofti microfilaremia (Mf) prevalence in the study communities had decreased between 2014 to 2018 from 12% to 0.9% (p<0.001). The prevalence of W. bancrofti antigenemia was also significantly reduced from 31.6% to 8.5% (p<0.001). MDA with albendazole also reduced hookworm, Ascaris lumbricoides and Trichuris trichiura infection prevalences in the community from 58.6% to 21.2% (p<0.001), from 14.0% to 1.6% and 4.1% to 2.9%, respectively. Hookworm and Ascaris infection intensities were reduced by 93% (p = 0.02) and 57% (p = 0.03), respectively. In contrast, Trichuris infection intensity was not significantly reduced by MDA (p = 0.61) over this time period.

CONCLUSION/SIGNIFICANCE

These results provide strong evidence that semiannual MDA with albendazole alone is a safe and effective strategy for LF elimination in Central Africa. Community MDA also had a major impact on STH infections.

Authors+Show Affiliations

French National Research Institute for Sustainable Development, Montpellier, France.French National Research Institute for Sustainable Development, Montpellier, France.French National Research Institute for Sustainable Development, Montpellier, France.Ministry of health, Kinshasa, Democratic Republic of the Congo. Ghent University, Merelbeke, Belgium.French National Research Institute for Sustainable Development, Montpellier, France.National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo.Ministry of health, Kinshasa, Democratic Republic of the Congo.Ministry of health, Kinshasa, Democratic Republic of the Congo.Washington University School of Medicine, St. Louis, Missouri, United States of America.French National Research Institute for Sustainable Development, Montpellier, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32574160

Citation

Pion, Sébastien D S., et al. "The Impact of Four Years of Semiannual Treatments With Albendazole Alone On Lymphatic Filariasis and Soil-transmitted Helminth Infections: a Community-based Study in the Democratic Republic of the Congo." PLoS Neglected Tropical Diseases, vol. 14, no. 6, 2020, pp. e0008322.
Pion SDS, Chesnais CB, Awaca-Uvon NP, et al. The impact of four years of semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: A community-based study in the Democratic Republic of the Congo. PLoS Negl Trop Dis. 2020;14(6):e0008322.
Pion, S. D. S., Chesnais, C. B., Awaca-Uvon, N. P., Vlaminck, J., Abdou, A., Kunyu-Shako, B., Kuyangisa Simuna, G., Tambwe, J. P., Weil, G. J., & Boussinesq, M. (2020). The impact of four years of semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: A community-based study in the Democratic Republic of the Congo. PLoS Neglected Tropical Diseases, 14(6), e0008322. https://doi.org/10.1371/journal.pntd.0008322
Pion SDS, et al. The Impact of Four Years of Semiannual Treatments With Albendazole Alone On Lymphatic Filariasis and Soil-transmitted Helminth Infections: a Community-based Study in the Democratic Republic of the Congo. PLoS Negl Trop Dis. 2020;14(6):e0008322. PubMed PMID: 32574160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of four years of semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: A community-based study in the Democratic Republic of the Congo. AU - Pion,Sébastien D S, AU - Chesnais,Cédric B, AU - Awaca-Uvon,Naomi P, AU - Vlaminck,Johnny, AU - Abdou,Anlimou, AU - Kunyu-Shako,Billy, AU - Kuyangisa Simuna,Godefroy, AU - Tambwe,Jean-Paul, AU - Weil,Gary J, AU - Boussinesq,Michel, Y1 - 2020/06/23/ PY - 2020/01/09/received PY - 2020/04/24/accepted PY - 2020/07/06/revised PY - 2020/6/24/pubmed PY - 2020/6/24/medline PY - 2020/6/24/entrez SP - e0008322 EP - e0008322 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 14 IS - 6 N2 - BACKGROUND: The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs. However, the published evidence base to support this policy is thin, and uptake by national programs has been slow. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a community trial to assess the impact of semiannual MDA on lymphatic filariasis and soil-transmitted helminth infections (STH) in two villages in the Bandundu province of the Democratic Republic of the Congo with moderately high prevalences for LF and hookworm infections. MDA with albendazole was provided every six months from June 2014 to December 2017 with treatment coverages of the eligible population (all ≥ 2 year of age) that ranged between 56% and 88%. No adverse effects were reported during the trial. Evaluation at 48 months, (i.e. 6 months after the 8th round of MDA), showed that W. bancrofti microfilaremia (Mf) prevalence in the study communities had decreased between 2014 to 2018 from 12% to 0.9% (p<0.001). The prevalence of W. bancrofti antigenemia was also significantly reduced from 31.6% to 8.5% (p<0.001). MDA with albendazole also reduced hookworm, Ascaris lumbricoides and Trichuris trichiura infection prevalences in the community from 58.6% to 21.2% (p<0.001), from 14.0% to 1.6% and 4.1% to 2.9%, respectively. Hookworm and Ascaris infection intensities were reduced by 93% (p = 0.02) and 57% (p = 0.03), respectively. In contrast, Trichuris infection intensity was not significantly reduced by MDA (p = 0.61) over this time period. CONCLUSION/SIGNIFICANCE: These results provide strong evidence that semiannual MDA with albendazole alone is a safe and effective strategy for LF elimination in Central Africa. Community MDA also had a major impact on STH infections. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/32574160/The_impact_of_four_years_of_semiannual_treatments_with_albendazole_alone_on_lymphatic_filariasis_and_soil-transmitted_helminth_infections:_A_community-based_study_in_the_Democratic_Republic_of_the_Congo L2 - https://dx.plos.org/10.1371/journal.pntd.0008322 DB - PRIME DP - Unbound Medicine ER -
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