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Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response.
Aging (Albany NY). 2020 06 23; 12(12):11277-11286.A

Abstract

Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide. To develop treatments that can stop or lessen the symptoms and severity of SARS-CoV-2 infection, it is critical to understand how the virus behaves inside human cells, and so far studies in this area remain scarce. A recent study investigated translatome and proteome host cell changes induced in vitro by SARS-CoV-2. Here, we use the publicly available proteomics data from this study to re-analyze the in vitro cellular consequences of SARS-CoV-2 infection by impact pathways analysis and network analysis. Notably, proteins linked to the inflammatory response, but also proteins related to chromosome segregation during mitosis, were found to be altered in response to viral infection. Upregulation of inflammatory response proteins is in line with the propagation of inflammatory reaction and lung injury that is observed in advanced stages of COVID-19 patients and which worsens with age.

Authors+Show Affiliations

Cobo Technologies Aps, Maaloev 2760, Denmark.Proteomics Unit, Universidad de Cádiz and Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz 11002, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32575076

Citation

Bock, Jens-Ole, and Ignacio Ortea. "Re-analysis of SARS-CoV-2-infected Host Cell Proteomics Time-course Data By Impact Pathway Analysis and Network Analysis: a Potential Link With Inflammatory Response." Aging, vol. 12, no. 12, 2020, pp. 11277-11286.
Bock JO, Ortea I. Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response. Aging (Albany NY). 2020;12(12):11277-11286.
Bock, J. O., & Ortea, I. (2020). Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response. Aging, 12(12), 11277-11286. https://doi.org/10.18632/aging.103524
Bock JO, Ortea I. Re-analysis of SARS-CoV-2-infected Host Cell Proteomics Time-course Data By Impact Pathway Analysis and Network Analysis: a Potential Link With Inflammatory Response. Aging (Albany NY). 2020 06 23;12(12):11277-11286. PubMed PMID: 32575076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response. AU - Bock,Jens-Ole, AU - Ortea,Ignacio, Y1 - 2020/06/23/ PY - 2020/03/31/received PY - 2020/05/30/accepted PY - 2020/6/24/pubmed PY - 2020/7/21/medline PY - 2020/6/24/entrez KW - COVID-19 KW - SARS-CoV-2 KW - inflammatory response KW - proteomics SP - 11277 EP - 11286 JF - Aging JO - Aging (Albany NY) VL - 12 IS - 12 N2 - Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide. To develop treatments that can stop or lessen the symptoms and severity of SARS-CoV-2 infection, it is critical to understand how the virus behaves inside human cells, and so far studies in this area remain scarce. A recent study investigated translatome and proteome host cell changes induced in vitro by SARS-CoV-2. Here, we use the publicly available proteomics data from this study to re-analyze the in vitro cellular consequences of SARS-CoV-2 infection by impact pathways analysis and network analysis. Notably, proteins linked to the inflammatory response, but also proteins related to chromosome segregation during mitosis, were found to be altered in response to viral infection. Upregulation of inflammatory response proteins is in line with the propagation of inflammatory reaction and lung injury that is observed in advanced stages of COVID-19 patients and which worsens with age. SN - 1945-4589 UR - https://www.unboundmedicine.com/medline/citation/32575076/Re_analysis_of_SARS_CoV_2_infected_host_cell_proteomics_time_course_data_by_impact_pathway_analysis_and_network_analysis:_a_potential_link_with_inflammatory_response_ L2 - https://www.impactaging.com/full/12/11277 DB - PRIME DP - Unbound Medicine ER -