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Heterochromatin Morphodynamics in Late Oogenesis and Early Embryogenesis of Mammals.
Cells. 2020 Jun 19; 9(6)C

Abstract

During the period of oocyte growth, chromatin undergoes global rearrangements at both morphological and molecular levels. An intriguing feature of oogenesis in some mammalian species is the formation of a heterochromatin ring-shaped structure, called the karyosphere or surrounded "nucleolus", which is associated with the periphery of the nucleolus-like bodies (NLBs). Morphologically similar heterochromatin structures also form around the nucleolus-precursor bodies (NPBs) in zygotes and persist for several first cleavage divisions in blastomeres. Despite recent progress in our understanding the regulation of gene silencing/expression during early mammalian development, as well as the molecular mechanisms that underlie chromatin condensation and heterochromatin structure, the biological significance of the karyosphere and its counterparts in early embryos is still elusive. We pay attention to both the changes of heterochromatin morphology and to the molecular mechanisms that can affect the configuration and functional activity of chromatin. We briefly discuss how DNA methylation, post-translational histone modifications, alternative histone variants, and some chromatin-associated non-histone proteins may be involved in the formation of peculiar heterochromatin structures intimately associated with NLBs and NPBs, the unique nuclear bodies of oocytes and early embryos.

Authors+Show Affiliations

Laboratory of Cell Morphology, Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky ave., St. Petersburg, 194064, Russia.Laboratory of Cell Morphology, Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky ave., St. Petersburg, 194064, Russia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32575486

Citation

Bogolyubova, Irina, and Dmitry Bogolyubov. "Heterochromatin Morphodynamics in Late Oogenesis and Early Embryogenesis of Mammals." Cells, vol. 9, no. 6, 2020.
Bogolyubova I, Bogolyubov D. Heterochromatin Morphodynamics in Late Oogenesis and Early Embryogenesis of Mammals. Cells. 2020;9(6).
Bogolyubova, I., & Bogolyubov, D. (2020). Heterochromatin Morphodynamics in Late Oogenesis and Early Embryogenesis of Mammals. Cells, 9(6). https://doi.org/10.3390/cells9061497
Bogolyubova I, Bogolyubov D. Heterochromatin Morphodynamics in Late Oogenesis and Early Embryogenesis of Mammals. Cells. 2020 Jun 19;9(6) PubMed PMID: 32575486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heterochromatin Morphodynamics in Late Oogenesis and Early Embryogenesis of Mammals. AU - Bogolyubova,Irina, AU - Bogolyubov,Dmitry, Y1 - 2020/06/19/ PY - 2020/05/13/received PY - 2020/06/10/revised PY - 2020/06/16/accepted PY - 2020/6/25/entrez PY - 2020/6/25/pubmed PY - 2020/6/25/medline KW - heterochromatin configuration KW - karyosphere KW - mammalian early development KW - oocytes KW - pre-implantation embryos JF - Cells JO - Cells VL - 9 IS - 6 N2 - During the period of oocyte growth, chromatin undergoes global rearrangements at both morphological and molecular levels. An intriguing feature of oogenesis in some mammalian species is the formation of a heterochromatin ring-shaped structure, called the karyosphere or surrounded "nucleolus", which is associated with the periphery of the nucleolus-like bodies (NLBs). Morphologically similar heterochromatin structures also form around the nucleolus-precursor bodies (NPBs) in zygotes and persist for several first cleavage divisions in blastomeres. Despite recent progress in our understanding the regulation of gene silencing/expression during early mammalian development, as well as the molecular mechanisms that underlie chromatin condensation and heterochromatin structure, the biological significance of the karyosphere and its counterparts in early embryos is still elusive. We pay attention to both the changes of heterochromatin morphology and to the molecular mechanisms that can affect the configuration and functional activity of chromatin. We briefly discuss how DNA methylation, post-translational histone modifications, alternative histone variants, and some chromatin-associated non-histone proteins may be involved in the formation of peculiar heterochromatin structures intimately associated with NLBs and NPBs, the unique nuclear bodies of oocytes and early embryos. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/32575486/Heterochromatin_Morphodynamics_in_Late_Oogenesis_and_Early_Embryogenesis_of_Mammals L2 - https://www.mdpi.com/resolver?pii=cells9061497 DB - PRIME DP - Unbound Medicine ER -
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