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Effects of Oral Antihistamines on Tear Volume, Tear Stability, and Intraocular Pressure.
Vision (Basel). 2020 Jun 20; 4(2)V

Abstract

The goal of this study was to investigate the effects of two commonly used oral antihistamines-diphenhydramine and loratadine-on tear volume, tear breakup time, and intraocular pressure. Placebo, diphenhydramine, and loratadine were administered for one week to 33 subjects experimentally blind to the treatment given. All the subjects received all three treatments over a period of six weeks. The outcome measures were the change in phenol red thread test (PRT), the tear breakup time (TBUT), and the intraocular pressure (IOP) of both eyes evaluated by experimentally masked observers. Neither of the mean changes in TBUT or IOP depended on the treatment given, but there was a significant monocular decrease in tear volume from diphenhydramine use. While we used an adequate treatment washout period of seven days, our investigation was limited by the short treatment times and inclusion of only young healthy patients. Overall, however, these results suggest that systemic diphenhydramine use should be limited to increase the effectiveness of conventional therapies. Clinicians should have fewer reservations about recommending the use of loratadine concurrent with dry eye treatments.

Authors+Show Affiliations

Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, TX 78229, USA.Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, TX 78229, USA.College of Optometry, University of Missouri-St Louis, St. Louis, MO 63121, USA.College of Optometry, University of Missouri-St Louis, St. Louis, MO 63121, USA. St. Louis College of Pharmacy, St. Louis, MO 63110, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32575705

Citation

Foutch, Brian K., et al. "Effects of Oral Antihistamines On Tear Volume, Tear Stability, and Intraocular Pressure." Vision (Basel, Switzerland), vol. 4, no. 2, 2020.
Foutch BK, Sandberg KA, Bennett ES, et al. Effects of Oral Antihistamines on Tear Volume, Tear Stability, and Intraocular Pressure. Vision (Basel). 2020;4(2).
Foutch, B. K., Sandberg, K. A., Bennett, E. S., & Naeger, L. L. (2020). Effects of Oral Antihistamines on Tear Volume, Tear Stability, and Intraocular Pressure. Vision (Basel, Switzerland), 4(2). https://doi.org/10.3390/vision4020032
Foutch BK, et al. Effects of Oral Antihistamines On Tear Volume, Tear Stability, and Intraocular Pressure. Vision (Basel). 2020 Jun 20;4(2) PubMed PMID: 32575705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Oral Antihistamines on Tear Volume, Tear Stability, and Intraocular Pressure. AU - Foutch,Brian K, AU - Sandberg,Kyle A, AU - Bennett,Edward S, AU - Naeger,Leonard L, Y1 - 2020/06/20/ PY - 2020/05/15/received PY - 2020/06/16/revised PY - 2020/06/18/accepted PY - 2020/6/25/entrez PY - 2020/6/25/pubmed PY - 2020/6/25/medline KW - antihistamine KW - diphenhydramine KW - intraocular pressure KW - loratadine KW - phenol red thread test KW - tear break-up time JF - Vision (Basel, Switzerland) JO - Vision (Basel) VL - 4 IS - 2 N2 - The goal of this study was to investigate the effects of two commonly used oral antihistamines-diphenhydramine and loratadine-on tear volume, tear breakup time, and intraocular pressure. Placebo, diphenhydramine, and loratadine were administered for one week to 33 subjects experimentally blind to the treatment given. All the subjects received all three treatments over a period of six weeks. The outcome measures were the change in phenol red thread test (PRT), the tear breakup time (TBUT), and the intraocular pressure (IOP) of both eyes evaluated by experimentally masked observers. Neither of the mean changes in TBUT or IOP depended on the treatment given, but there was a significant monocular decrease in tear volume from diphenhydramine use. While we used an adequate treatment washout period of seven days, our investigation was limited by the short treatment times and inclusion of only young healthy patients. Overall, however, these results suggest that systemic diphenhydramine use should be limited to increase the effectiveness of conventional therapies. Clinicians should have fewer reservations about recommending the use of loratadine concurrent with dry eye treatments. SN - 2411-5150 UR - https://www.unboundmedicine.com/medline/citation/32575705/Effects_of_Oral_Antihistamines_on_Tear_Volume,_Tear_Stability,_and_Intraocular_Pressure L2 - https://www.mdpi.com/resolver?pii=vision4020032 DB - PRIME DP - Unbound Medicine ER -
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