Tags

Type your tag names separated by a space and hit enter

Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity.
Nat Commun. 2020 06 23; 11(1):3178.NC

Abstract

Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry. We herein report a highly efficient self-assembly of heterometallic triangular necklace 1 containing Cu and Pt metals with strong antibacterial activity. Single-crystal X-ray analysis shows that the finely arranged triangular necklace 1 has two racemic enantiomers in its solid state with intriguing packing motif. The superior antibacterial activity of necklace 1 against both standard and clinically drug-resistant pathogens implies that the presence of Cu(I) center and platinum(II) significantly enhance the bacterium-binding/damaging activity, which is mainly attributed to the highly positively charged nature, the possible synergistic effect of heterometals in the necklace, and the improved stability in culture media. This work clearly discloses the structure-property relationships that the existence of two different metal centers not only facilitates successful construction of heterometallic triangular necklace but also endows it with superior nuclease properties and antibacterial activities.

Authors+Show Affiliations

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N. Zhongshan Road, Shanghai, 200062, P. R. China.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N. Zhongshan Road, Shanghai, 200062, P. R. China. xlshi@chem.ecnu.edu.cn.Vinh University, 182 LeDuan Street, Vinh, Vietnam.State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N. Zhongshan Road, Shanghai, 200062, P. R. China.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N. Zhongshan Road, Shanghai, 200062, P. R. China.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N. Zhongshan Road, Shanghai, 200062, P. R. China.Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N. Zhongshan Road, Shanghai, 200062, P. R. China.Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, P. R. China. yuqilin@mail.nankai.edu.cn.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N. Zhongshan Road, Shanghai, 200062, P. R. China. hbyang@chem.ecnu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32576814

Citation

Wu, Gui-Yuan, et al. "Efficient Self-assembly of Heterometallic Triangular Necklace With Strong Antibacterial Activity." Nature Communications, vol. 11, no. 1, 2020, p. 3178.
Wu GY, Shi X, Phan H, et al. Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity. Nat Commun. 2020;11(1):3178.
Wu, G. Y., Shi, X., Phan, H., Qu, H., Hu, Y. X., Yin, G. Q., Zhao, X. L., Li, X., Xu, L., Yu, Q., & Yang, H. B. (2020). Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity. Nature Communications, 11(1), 3178. https://doi.org/10.1038/s41467-020-16940-z
Wu GY, et al. Efficient Self-assembly of Heterometallic Triangular Necklace With Strong Antibacterial Activity. Nat Commun. 2020 06 23;11(1):3178. PubMed PMID: 32576814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity. AU - Wu,Gui-Yuan, AU - Shi,Xueliang, AU - Phan,Hoa, AU - Qu,Hang, AU - Hu,Yi-Xiong, AU - Yin,Guang-Qiang, AU - Zhao,Xiao-Li, AU - Li,Xiaopeng, AU - Xu,Lin, AU - Yu,Qilin, AU - Yang,Hai-Bo, Y1 - 2020/06/23/ PY - 2019/09/25/received PY - 2020/05/21/accepted PY - 2020/6/25/entrez PY - 2020/6/25/pubmed PY - 2020/6/25/medline SP - 3178 EP - 3178 JF - Nature communications JO - Nat Commun VL - 11 IS - 1 N2 - Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry. We herein report a highly efficient self-assembly of heterometallic triangular necklace 1 containing Cu and Pt metals with strong antibacterial activity. Single-crystal X-ray analysis shows that the finely arranged triangular necklace 1 has two racemic enantiomers in its solid state with intriguing packing motif. The superior antibacterial activity of necklace 1 against both standard and clinically drug-resistant pathogens implies that the presence of Cu(I) center and platinum(II) significantly enhance the bacterium-binding/damaging activity, which is mainly attributed to the highly positively charged nature, the possible synergistic effect of heterometals in the necklace, and the improved stability in culture media. This work clearly discloses the structure-property relationships that the existence of two different metal centers not only facilitates successful construction of heterometallic triangular necklace but also endows it with superior nuclease properties and antibacterial activities. SN - 2041-1723 UR - https://www.unboundmedicine.com/medline/citation/32576814/Efficient_self-assembly_of_heterometallic_triangular_necklace_with_strong_antibacterial_activity L2 - http://dx.doi.org/10.1038/s41467-020-16940-z DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.