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Advances in drug delivery systems: Work in progress still needed?
Int J Pharm X. 2020 Dec; 2:100050.IJ

Abstract

A new era of science and technology has emerged in pharmaceutical research with focus on developing novel drug delivery systems for oral administration. Conventional dosage forms like tablets and capsules are associated with a low bioavailability, frequent application, side effects and hence patient noncompliance. By developing novel strategies for drug delivery, researchers embraced an alternative to traditional drug delivery systems. Out of those, fast dissolving drug delivery systems are very eminent among pediatrics and geriatrics. Orally disintegrating films are superior over fast dissolving tablets as the latter are assigned with the risk of suffocation. Due to their ability of bypassing the dissolution and the first pass effect after oral administration, self-emulsifying formulations have also become increasingly popular in improving oral bioavailability of hydrophobic drugs. Osmotic devices enable a controlled drug delivery independent upon gastrointestinal conditions using osmosis as driving force. The advances in nanotechnology and the variety of possible materials and formulation factors enable a targeted delivery and triggered release. Vesicular systems can be easily modified as required and provide a controlled and sustained drug delivery to a specific site. This work provides an insight of the novel approaches in drug delivery covering the critical comparison between traditional and novel "advanced-designed" systems.

Authors+Show Affiliations

University of Innsbruck, Institute of Pharmacy, Department of Pharmaceutical Technology, Center for Molecular Biosciences Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.University of Innsbruck, Institute of Pharmacy, Department of Pharmaceutical Technology, Center for Molecular Biosciences Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32577616

Citation

Laffleur, Flavia, and Valérie Keckeis. "Advances in Drug Delivery Systems: Work in Progress Still Needed?" International Journal of Pharmaceutics: X, vol. 2, 2020, p. 100050.
Laffleur F, Keckeis V. Advances in drug delivery systems: Work in progress still needed? Int J Pharm X. 2020;2:100050.
Laffleur, F., & Keckeis, V. (2020). Advances in drug delivery systems: Work in progress still needed? International Journal of Pharmaceutics: X, 2, 100050. https://doi.org/10.1016/j.ijpx.2020.100050
Laffleur F, Keckeis V. Advances in Drug Delivery Systems: Work in Progress Still Needed. Int J Pharm X. 2020;2:100050. PubMed PMID: 32577616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances in drug delivery systems: Work in progress still needed? AU - Laffleur,Flavia, AU - Keckeis,Valérie, Y1 - 2020/06/12/ PY - 2020/03/04/received PY - 2020/06/03/revised PY - 2020/06/10/accepted PY - 2020/6/25/entrez PY - 2020/6/25/pubmed PY - 2020/6/25/medline KW - Fast dissolving KW - Nanoparticulate KW - Osmotic KW - Selfemulsifying KW - Vesicular SP - 100050 EP - 100050 JF - International journal of pharmaceutics: X JO - Int J Pharm X VL - 2 N2 - A new era of science and technology has emerged in pharmaceutical research with focus on developing novel drug delivery systems for oral administration. Conventional dosage forms like tablets and capsules are associated with a low bioavailability, frequent application, side effects and hence patient noncompliance. By developing novel strategies for drug delivery, researchers embraced an alternative to traditional drug delivery systems. Out of those, fast dissolving drug delivery systems are very eminent among pediatrics and geriatrics. Orally disintegrating films are superior over fast dissolving tablets as the latter are assigned with the risk of suffocation. Due to their ability of bypassing the dissolution and the first pass effect after oral administration, self-emulsifying formulations have also become increasingly popular in improving oral bioavailability of hydrophobic drugs. Osmotic devices enable a controlled drug delivery independent upon gastrointestinal conditions using osmosis as driving force. The advances in nanotechnology and the variety of possible materials and formulation factors enable a targeted delivery and triggered release. Vesicular systems can be easily modified as required and provide a controlled and sustained drug delivery to a specific site. This work provides an insight of the novel approaches in drug delivery covering the critical comparison between traditional and novel "advanced-designed" systems. SN - 2590-1567 UR - https://www.unboundmedicine.com/medline/citation/32577616/Advances_in_drug_delivery_systems:_Work_in_progress_still_needed L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32577616/ DB - PRIME DP - Unbound Medicine ER -
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