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Genetic Factors and Delayed TSB Monitoring and Treatment as Risk Factors Associated with Severe Hyperbilirubinemia in Term Neonates Admitted for Phototherapy.
J Trop Pediatr. 2020 Jun 24 [Online ahead of print]JT

Abstract

OBJECTIVES

This study aimed to determine whether maternal-fetal blood group isoimmunization, breastfeeding, birth trauma, age when first total serum bilirubin (TSB) was measured, age of admission, and genetic predispositions to hemolysis [due to genetic variants of glucose-6-phosphate dehydrogenase (G6PD) enzyme], and reduced hepatic uptake and/or conjugation of serum bilirubin [due to genetic variants of solute carrier organic anion transporter protein family member 1B1 (SLCO1B1) and uridine diphosphate glucuronosyltransferase family 1 member A1 (UGT1A1)] were significant risk factors associated with severe neonatal hyperbilirubinemia (SNH, TSB ≥ 342µmol/l) in jaundiced term neonates admitted for phototherapy.

METHODS

The inclusion criteria were normal term neonates (gestation ≥ 37 weeks). Parents/care-givers were interviewed to obtain data on demography, clinical problems, feeding practice and age when first TSB was measured. Polymerase chain reaction-restriction fragment length polymorphism method was used to detect common G6PD, UGT1A1 and SLCO1B1 variants on each neonate's dry blood specimens.

RESULTS

Of 1121 jaundiced neonates recruited, 232 had SNH. Logistic regression analysis showed that age (in days) when first TSB was measured [adjusted odds ratio (aOR) = 1.395; 95% confidence interval (CI) 1.094-1.779], age (in days) of admission (aOR = 1.127; 95% CI 1.007-1.260) and genetic mutant UGT1A1 promoter A(TA)7TAA (aOR = 4.900; 95% CI 3.103-7.739), UGT1A1 c.686C>A (aOR = 6.095; 95% CI 1.549-23.985), SLCO1B1 c.388G>A (aOR = 1.807; 95% CI 1.242-2.629) and G6PD variants and/or abnormal G6PD screening test (aOR = 2.077; 95% CI 1.025-4.209) were significantly associated with SNH.

CONCLUSION

Genetic predisposition, and delayed measuring first TSB and commencing phototherapy increased risk of SNH.

Authors+Show Affiliations

Department of Population Medicine, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Bandar Sungai Long, Selangor, Malaysia.Department of Pre-Clinical Science, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Bandar Sungai Long, Selangor, Malaysia.Department of Pediatrics, Selayang Hospital, Selayang, Selangor, Malaysia.Department of Pediatrics, Selayang Hospital, Selayang, Selangor, Malaysia.Department of Pediatrics, Selayang Hospital, Selayang, Selangor, Malaysia.Department of Pediatrics, Selayang Hospital, Selayang, Selangor, Malaysia.Department of Pre-Clinical Science, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Bandar Sungai Long, Selangor, Malaysia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32577754

Citation

Boo, Nem-Yun, et al. "Genetic Factors and Delayed TSB Monitoring and Treatment as Risk Factors Associated With Severe Hyperbilirubinemia in Term Neonates Admitted for Phototherapy." Journal of Tropical Pediatrics, 2020.
Boo NY, Sin S, Chee SC, et al. Genetic Factors and Delayed TSB Monitoring and Treatment as Risk Factors Associated with Severe Hyperbilirubinemia in Term Neonates Admitted for Phototherapy. J Trop Pediatr. 2020.
Boo, N. Y., Sin, S., Chee, S. C., Mohamed, M., Ahluwalia, A. K., Ling, M. M., & Ong, H. K. (2020). Genetic Factors and Delayed TSB Monitoring and Treatment as Risk Factors Associated with Severe Hyperbilirubinemia in Term Neonates Admitted for Phototherapy. Journal of Tropical Pediatrics. https://doi.org/10.1093/tropej/fmaa016
Boo NY, et al. Genetic Factors and Delayed TSB Monitoring and Treatment as Risk Factors Associated With Severe Hyperbilirubinemia in Term Neonates Admitted for Phototherapy. J Trop Pediatr. 2020 Jun 24; PubMed PMID: 32577754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic Factors and Delayed TSB Monitoring and Treatment as Risk Factors Associated with Severe Hyperbilirubinemia in Term Neonates Admitted for Phototherapy. AU - Boo,Nem-Yun, AU - Sin,Shwe, AU - Chee,Seok-Chiong, AU - Mohamed,Maslina, AU - Ahluwalia,Anita Kaur, AU - Ling,Michelle Min-Min, AU - Ong,Han-Kiat, Y1 - 2020/06/24/ PY - 2020/6/25/entrez KW - age when first TSB was measured KW - genetic predisposition KW - risk factors KW - severe neonatal hyperbilirubinemia JF - Journal of tropical pediatrics JO - J. Trop. Pediatr. N2 - OBJECTIVES: This study aimed to determine whether maternal-fetal blood group isoimmunization, breastfeeding, birth trauma, age when first total serum bilirubin (TSB) was measured, age of admission, and genetic predispositions to hemolysis [due to genetic variants of glucose-6-phosphate dehydrogenase (G6PD) enzyme], and reduced hepatic uptake and/or conjugation of serum bilirubin [due to genetic variants of solute carrier organic anion transporter protein family member 1B1 (SLCO1B1) and uridine diphosphate glucuronosyltransferase family 1 member A1 (UGT1A1)] were significant risk factors associated with severe neonatal hyperbilirubinemia (SNH, TSB ≥ 342µmol/l) in jaundiced term neonates admitted for phototherapy. METHODS: The inclusion criteria were normal term neonates (gestation ≥ 37 weeks). Parents/care-givers were interviewed to obtain data on demography, clinical problems, feeding practice and age when first TSB was measured. Polymerase chain reaction-restriction fragment length polymorphism method was used to detect common G6PD, UGT1A1 and SLCO1B1 variants on each neonate's dry blood specimens. RESULTS: Of 1121 jaundiced neonates recruited, 232 had SNH. Logistic regression analysis showed that age (in days) when first TSB was measured [adjusted odds ratio (aOR) = 1.395; 95% confidence interval (CI) 1.094-1.779], age (in days) of admission (aOR = 1.127; 95% CI 1.007-1.260) and genetic mutant UGT1A1 promoter A(TA)7TAA (aOR = 4.900; 95% CI 3.103-7.739), UGT1A1 c.686C>A (aOR = 6.095; 95% CI 1.549-23.985), SLCO1B1 c.388G>A (aOR = 1.807; 95% CI 1.242-2.629) and G6PD variants and/or abnormal G6PD screening test (aOR = 2.077; 95% CI 1.025-4.209) were significantly associated with SNH. CONCLUSION: Genetic predisposition, and delayed measuring first TSB and commencing phototherapy increased risk of SNH. SN - 1465-3664 UR - https://www.unboundmedicine.com/medline/citation/32577754/Genetic_Factors_and_Delayed_TSB_Monitoring_and_Treatment_as_Risk_Factors_Associated_with_Severe_Hyperbilirubinemia_in_Term_Neonates_Admitted_for_Phototherapy L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/fmaa016 DB - PRIME DP - Unbound Medicine ER -
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