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Preliminary assessment of antimicrobial activity and acute toxicity of norfloxacin chlorination by-product mixture.
Environ Sci Pollut Res Int. 2020 Jun 23 [Online ahead of print]ES

Abstract

Among drugs and personal care products, antibiotics arouse interest since they are widely used in human and veterinary medicine and can lead to the development of bacterial resistance. Usually, sewage treatment does not remove most of these compounds. So, these drugs can reach water treatment plants (WTP), where disinfection with chlorine compounds is common. This work aimed to evaluate the antimicrobial activity and preliminary toxicity of the mix of by-products forming due to the chlorination of norfloxacin. This is a fluoroquinolone antibiotic indicated for the treatment of urinary infection and gonorrhea, with sodium hypochlorite (NaClO). The drug was subjected to chlorination tests, on a bench scale, with several reaction times (from 5 min to 24 h). Analyses of high-resolution mass spectrometry (MS) were performed for the characterization of the by-products. The MS results showed five peaks attributed to the by-products' formation, of which four were identified. The antibiogram results indicated that the solution that contained the mixture of the by-products lost antibacterial activity against the E. coli strain studied. The acute toxicity tests for the Artemia salina microcrustacean showed that the blend of the by-products exhibited higher toxicity than pure norfloxacin.

Authors+Show Affiliations

Graduate Program of Environmental Engineering, Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil. medicerv@usp.br. University of São Paulo (USP), São Paulo, Brazil. medicerv@usp.br.Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil.Department of Materials and Metallurgical Engineering, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.Department of Chemistry, Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil.Department of Sanitary and Environmental Engineering, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32577976

Citation

Médice, Rhuana Valdetário, et al. "Preliminary Assessment of Antimicrobial Activity and Acute Toxicity of Norfloxacin Chlorination By-product Mixture." Environmental Science and Pollution Research International, 2020.
Médice RV, Afonso RJCF, Almeida MLB, et al. Preliminary assessment of antimicrobial activity and acute toxicity of norfloxacin chlorination by-product mixture. Environ Sci Pollut Res Int. 2020.
Médice, R. V., Afonso, R. J. C. F., Almeida, M. L. B., de Aquino, S. F., & Libânio, M. (2020). Preliminary assessment of antimicrobial activity and acute toxicity of norfloxacin chlorination by-product mixture. Environmental Science and Pollution Research International. https://doi.org/10.1007/s11356-020-09748-3
Médice RV, et al. Preliminary Assessment of Antimicrobial Activity and Acute Toxicity of Norfloxacin Chlorination By-product Mixture. Environ Sci Pollut Res Int. 2020 Jun 23; PubMed PMID: 32577976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preliminary assessment of antimicrobial activity and acute toxicity of norfloxacin chlorination by-product mixture. AU - Médice,Rhuana Valdetário, AU - Afonso,Robson José de Cássia Franco, AU - Almeida,Marys Lene Braga, AU - de Aquino,Sérgio Francisco, AU - Libânio,Marcelo, Y1 - 2020/06/23/ PY - 2020/02/10/received PY - 2020/06/15/accepted PY - 2020/6/25/entrez KW - Antibiogram KW - Antibiotics, KW - Disinfection by-products, KW - Fluoroquinolones, KW - Mass spectrometry, KW - Toxicity, JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int N2 - Among drugs and personal care products, antibiotics arouse interest since they are widely used in human and veterinary medicine and can lead to the development of bacterial resistance. Usually, sewage treatment does not remove most of these compounds. So, these drugs can reach water treatment plants (WTP), where disinfection with chlorine compounds is common. This work aimed to evaluate the antimicrobial activity and preliminary toxicity of the mix of by-products forming due to the chlorination of norfloxacin. This is a fluoroquinolone antibiotic indicated for the treatment of urinary infection and gonorrhea, with sodium hypochlorite (NaClO). The drug was subjected to chlorination tests, on a bench scale, with several reaction times (from 5 min to 24 h). Analyses of high-resolution mass spectrometry (MS) were performed for the characterization of the by-products. The MS results showed five peaks attributed to the by-products' formation, of which four were identified. The antibiogram results indicated that the solution that contained the mixture of the by-products lost antibacterial activity against the E. coli strain studied. The acute toxicity tests for the Artemia salina microcrustacean showed that the blend of the by-products exhibited higher toxicity than pure norfloxacin. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/32577976/Preliminary_assessment_of_antimicrobial_activity_and_acute_toxicity_of_norfloxacin_chlorination_by-product_mixture L2 - https://dx.doi.org/10.1007/s11356-020-09748-3 DB - PRIME DP - Unbound Medicine ER -
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