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2D MS/MS Spectra Recorded in the Time Domain Using Repetitive Frequency Sweeps in Linear Quadrupole Ion Traps.
Anal Chem. 2020 07 21; 92(14):10016-10023.AC

Abstract

Ion trap mass spectrometers have emerged as powerful on-site analytical platforms, in spite of limited mass resolution, due to their compatibility with ambient ionization methods and ready implementation of tandem mass spectrometry (MS/MS). When operated at constant trapping voltage, ions can be activated at their secular frequencies and all MS/MS experiments can be performed, including the two-dimensional tandem mass scan (2D MS/MS scan) in which all precursor ions and their subsequent product ions are both identified and correlated. In the new method of performing this 2D MS/MS experiment presented here, the precursor ions are excited by a nonlinear (inverse Mathieu q) frequency sweep while the resulting product ions are identified by their ejection time within a repeating orthogonally applied nonlinear (inverse Mathieu q) frequency sweep. This resulting compact representation contains the total fragmentation behavior of a collection of ionized compounds and captures detailed chemical information efficiently (typically in 1 s). The approach is implemented using a simple single mass analyzer instrument. This methodology was tested on three different multicomponent mixtures: drugs of abuse, peptides, and fentanyl analogs. The data are compared with those obtained by more common MS/MS scan methods.

Authors+Show Affiliations

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

32578980

Citation

Szalwinski, Lucas J., et al. "2D MS/MS Spectra Recorded in the Time Domain Using Repetitive Frequency Sweeps in Linear Quadrupole Ion Traps." Analytical Chemistry, vol. 92, no. 14, 2020, pp. 10016-10023.
Szalwinski LJ, Holden DT, Morato NM, et al. 2D MS/MS Spectra Recorded in the Time Domain Using Repetitive Frequency Sweeps in Linear Quadrupole Ion Traps. Anal Chem. 2020;92(14):10016-10023.
Szalwinski, L. J., Holden, D. T., Morato, N. M., & Cooks, R. G. (2020). 2D MS/MS Spectra Recorded in the Time Domain Using Repetitive Frequency Sweeps in Linear Quadrupole Ion Traps. Analytical Chemistry, 92(14), 10016-10023. https://doi.org/10.1021/acs.analchem.0c01719
Szalwinski LJ, et al. 2D MS/MS Spectra Recorded in the Time Domain Using Repetitive Frequency Sweeps in Linear Quadrupole Ion Traps. Anal Chem. 2020 07 21;92(14):10016-10023. PubMed PMID: 32578980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 2D MS/MS Spectra Recorded in the Time Domain Using Repetitive Frequency Sweeps in Linear Quadrupole Ion Traps. AU - Szalwinski,Lucas J, AU - Holden,Dylan T, AU - Morato,Nicolás M, AU - Cooks,R Graham, Y1 - 2020/07/07/ PY - 2020/6/25/pubmed PY - 2020/6/25/medline PY - 2020/6/25/entrez SP - 10016 EP - 10023 JF - Analytical chemistry JO - Anal. Chem. VL - 92 IS - 14 N2 - Ion trap mass spectrometers have emerged as powerful on-site analytical platforms, in spite of limited mass resolution, due to their compatibility with ambient ionization methods and ready implementation of tandem mass spectrometry (MS/MS). When operated at constant trapping voltage, ions can be activated at their secular frequencies and all MS/MS experiments can be performed, including the two-dimensional tandem mass scan (2D MS/MS scan) in which all precursor ions and their subsequent product ions are both identified and correlated. In the new method of performing this 2D MS/MS experiment presented here, the precursor ions are excited by a nonlinear (inverse Mathieu q) frequency sweep while the resulting product ions are identified by their ejection time within a repeating orthogonally applied nonlinear (inverse Mathieu q) frequency sweep. This resulting compact representation contains the total fragmentation behavior of a collection of ionized compounds and captures detailed chemical information efficiently (typically in 1 s). The approach is implemented using a simple single mass analyzer instrument. This methodology was tested on three different multicomponent mixtures: drugs of abuse, peptides, and fentanyl analogs. The data are compared with those obtained by more common MS/MS scan methods. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/32578980/2D_MS/MS_Spectra_Recorded_in_the_Time_Domain_Using_Repetitive_Frequency_Sweeps_in_Linear_Quadrupole_Ion_Traps_ L2 - https://doi.org/10.1021/acs.analchem.0c01719 DB - PRIME DP - Unbound Medicine ER -
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