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High risk of colorectal polyps in men with non-alcoholic fatty liver disease: A systematic review and meta-analysis.
J Gastroenterol Hepatol. 2020 Dec; 35(12):2051-2065.JG

Abstract

BACKGROUND AND AIM

This meta-analysis aims to explore the risk of colorectal polyps among non-alcoholic fatty liver disease (NAFLD) patients.

METHODS

We searched PubMed, EMBASE, and Cochrane library databases using predefined search term to identify eligible studies (published up to 7 November 2019). Data from selected studies were extracted by using a standardized information collection form, and meta-analyses were performed using random-effects model. The statistical heterogeneity among studies (I2), subgroup analyses, meta-regression analyses, and the possibility of publication bias were assessed.

RESULTS

Twenty observational (12 cross-sectional, two case-control, and six cohort) studies met the eligibility criteria, involving 142 387 asymptomatic adults. In cross-sectional/case-control studies, NAFLD was found to be associated with an increased risk of colorectal polyps (odds ratio [OR] = 1.34; 95% confidence interval [CI] = 1.23-1.47) (including unclassified colorectal polyps, hyperplastic polyps, adenomas, and cancers) with statistically significant heterogeneity (I2 = 67.8%; P < 0.001). NAFLD was also associated with a higher risk of incident colorectal polyps (hazard ratio = 1.60; 95% CI = 1.36-1.87) with low heterogeneity (I2 = 21.8%; P = 0.263) in longitudinal studies. The severity of NAFLD was associated with a higher risk of colorectal adenomas (OR = 1.57; 95% CI = 1.30-1.88), but not colorectal cancer (OR = 1.37; 95% CI = 0.92-2.03). The subgroup analysis according to gender showed that NAFLD was significantly associated with a higher risk of colorectal polyps in the male population without significant heterogeneity (OR = 1.47; 95% CI = 1.29-1.67, I2 = 0%), but not in the female population (OR = 0.88; 95% CI = 0.60-1.29, I2 = 34.2%).

CONCLUSIONS

NAFLD was associated with an increased risk of colorectal polyps. There was a significant difference of the relationship between genders, which suggested more precise screening colonoscopy recommendation in NAFLD patients according to gender.

Authors+Show Affiliations

Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32579269

Citation

Chen, Wenxia, et al. "High Risk of Colorectal Polyps in Men With Non-alcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis." Journal of Gastroenterology and Hepatology, vol. 35, no. 12, 2020, pp. 2051-2065.
Chen W, Wang M, Jing X, et al. High risk of colorectal polyps in men with non-alcoholic fatty liver disease: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2020;35(12):2051-2065.
Chen, W., Wang, M., Jing, X., Wu, C., Zeng, Y., Peng, J., & Cai, X. (2020). High risk of colorectal polyps in men with non-alcoholic fatty liver disease: A systematic review and meta-analysis. Journal of Gastroenterology and Hepatology, 35(12), 2051-2065. https://doi.org/10.1111/jgh.15158
Chen W, et al. High Risk of Colorectal Polyps in Men With Non-alcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis. J Gastroenterol Hepatol. 2020;35(12):2051-2065. PubMed PMID: 32579269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High risk of colorectal polyps in men with non-alcoholic fatty liver disease: A systematic review and meta-analysis. AU - Chen,Wenxia, AU - Wang,Muqing, AU - Jing,Xubin, AU - Wu,Chaofen, AU - Zeng,Yicheng, AU - Peng,Jianwei, AU - Cai,Xianbin, Y1 - 2020/07/07/ PY - 2020/03/18/received PY - 2020/06/05/revised PY - 2020/06/14/accepted PY - 2020/6/25/pubmed PY - 2021/7/31/medline PY - 2020/6/25/entrez KW - Colonic polyps KW - Meta-analysis KW - Non-alcoholic fatty liver disease SP - 2051 EP - 2065 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 35 IS - 12 N2 - BACKGROUND AND AIM: This meta-analysis aims to explore the risk of colorectal polyps among non-alcoholic fatty liver disease (NAFLD) patients. METHODS: We searched PubMed, EMBASE, and Cochrane library databases using predefined search term to identify eligible studies (published up to 7 November 2019). Data from selected studies were extracted by using a standardized information collection form, and meta-analyses were performed using random-effects model. The statistical heterogeneity among studies (I2), subgroup analyses, meta-regression analyses, and the possibility of publication bias were assessed. RESULTS: Twenty observational (12 cross-sectional, two case-control, and six cohort) studies met the eligibility criteria, involving 142 387 asymptomatic adults. In cross-sectional/case-control studies, NAFLD was found to be associated with an increased risk of colorectal polyps (odds ratio [OR] = 1.34; 95% confidence interval [CI] = 1.23-1.47) (including unclassified colorectal polyps, hyperplastic polyps, adenomas, and cancers) with statistically significant heterogeneity (I2 = 67.8%; P < 0.001). NAFLD was also associated with a higher risk of incident colorectal polyps (hazard ratio = 1.60; 95% CI = 1.36-1.87) with low heterogeneity (I2 = 21.8%; P = 0.263) in longitudinal studies. The severity of NAFLD was associated with a higher risk of colorectal adenomas (OR = 1.57; 95% CI = 1.30-1.88), but not colorectal cancer (OR = 1.37; 95% CI = 0.92-2.03). The subgroup analysis according to gender showed that NAFLD was significantly associated with a higher risk of colorectal polyps in the male population without significant heterogeneity (OR = 1.47; 95% CI = 1.29-1.67, I2 = 0%), but not in the female population (OR = 0.88; 95% CI = 0.60-1.29, I2 = 34.2%). CONCLUSIONS: NAFLD was associated with an increased risk of colorectal polyps. There was a significant difference of the relationship between genders, which suggested more precise screening colonoscopy recommendation in NAFLD patients according to gender. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/32579269/High_risk_of_colorectal_polyps_in_men_with_non_alcoholic_fatty_liver_disease:_A_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -