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Mass spectrometric analysis to unravel the venom proteome composition of Indian snakes: opening new avenues in clinical research.
Expert Rev Proteomics. 2020 May; 17(5):411-423.ER

Abstract

INTRODUCTION

The 'Big Four' venomous snakes - Daboia russelii, Naja naja, Bungarus caeruleus, and Echis carinatus - are primarily responsible for the majority of snake envenomation in India. Several other lesser-known venomous snake species also inflict severe envenomation in the country.

AREAS COVERED

A comprehensive analysis of the venom proteome composition of the 'Big Four' and other medically important venomous snakes of India and the effect of regional variation in venom composition on immunorecognition and/or neutralization by commercial antivenom was undertaken by searching the literature (from 1985 to date) available in large public databases. Further, mass spectrometric identification of poorly immunogenic toxins of snake venom (against which commercial polyvalent antivenom contains a significantly lower proportion of antibodies) and its impact on antivenom therapy against snakebite are discussed. The application of mass spectrometry to identify protein (toxin) complexes as well as drug prototypes from Indian snake venoms and the clinical importance of such studies are also highlighted.

EXPERT OPINION

Further detailed clinical and proteomic research is warranted to better understand the effects of regional snake venom composition on the clinical manifestation of envenomation and antivenom therapy and to improve the production of antibodies against poorly immunogenic venom components.

Authors+Show Affiliations

Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University , Tezpur, Assam, India.Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University , Tezpur, Assam, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32579411

Citation

Chanda, Abhishek, and Ashis K. Mukherjee. "Mass Spectrometric Analysis to Unravel the Venom Proteome Composition of Indian Snakes: Opening New Avenues in Clinical Research." Expert Review of Proteomics, vol. 17, no. 5, 2020, pp. 411-423.
Chanda A, Mukherjee AK. Mass spectrometric analysis to unravel the venom proteome composition of Indian snakes: opening new avenues in clinical research. Expert Rev Proteomics. 2020;17(5):411-423.
Chanda, A., & Mukherjee, A. K. (2020). Mass spectrometric analysis to unravel the venom proteome composition of Indian snakes: opening new avenues in clinical research. Expert Review of Proteomics, 17(5), 411-423. https://doi.org/10.1080/14789450.2020.1778471
Chanda A, Mukherjee AK. Mass Spectrometric Analysis to Unravel the Venom Proteome Composition of Indian Snakes: Opening New Avenues in Clinical Research. Expert Rev Proteomics. 2020;17(5):411-423. PubMed PMID: 32579411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mass spectrometric analysis to unravel the venom proteome composition of Indian snakes: opening new avenues in clinical research. AU - Chanda,Abhishek, AU - Mukherjee,Ashis K, Y1 - 2020/06/24/ PY - 2020/6/25/pubmed PY - 2020/6/25/medline PY - 2020/6/25/entrez KW - Big Four venomous snakes KW - India KW - Snake venom KW - antivenomics KW - envenomation KW - geographical variation KW - proteomics KW - snake venom neutralization KW - venomics SP - 411 EP - 423 JF - Expert review of proteomics JO - Expert Rev Proteomics VL - 17 IS - 5 N2 - INTRODUCTION: The 'Big Four' venomous snakes - Daboia russelii, Naja naja, Bungarus caeruleus, and Echis carinatus - are primarily responsible for the majority of snake envenomation in India. Several other lesser-known venomous snake species also inflict severe envenomation in the country. AREAS COVERED: A comprehensive analysis of the venom proteome composition of the 'Big Four' and other medically important venomous snakes of India and the effect of regional variation in venom composition on immunorecognition and/or neutralization by commercial antivenom was undertaken by searching the literature (from 1985 to date) available in large public databases. Further, mass spectrometric identification of poorly immunogenic toxins of snake venom (against which commercial polyvalent antivenom contains a significantly lower proportion of antibodies) and its impact on antivenom therapy against snakebite are discussed. The application of mass spectrometry to identify protein (toxin) complexes as well as drug prototypes from Indian snake venoms and the clinical importance of such studies are also highlighted. EXPERT OPINION: Further detailed clinical and proteomic research is warranted to better understand the effects of regional snake venom composition on the clinical manifestation of envenomation and antivenom therapy and to improve the production of antibodies against poorly immunogenic venom components. SN - 1744-8387 UR - https://www.unboundmedicine.com/medline/citation/32579411/Mass_spectrometric_analysis_to_unravel_the_venom_proteome_composition_of_Indian_snakes:_opening_new_avenues_in_clinical_research L2 - http://www.tandfonline.com/doi/full/10.1080/14789450.2020.1778471 DB - PRIME DP - Unbound Medicine ER -
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