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A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs.
Microbes Infect. 2020 Jun 21 [Online ahead of print]MI

Abstract

Encephalitozoon cuniculi genotype III disseminated intensively into most of the organs in all strains of mice, followed by a chronic infection with massive microsporidia persistence in immunodeficient mice and a partial decrease in C57Bl/6 mice. Treatment with 0.2 mg Albendazole/mouse/day temporarily reduces the number of affected organs in immunocompetent C57Bl/6 mice, but not in CD4-/- and CD8-/- mice. The application of medication temporarily decreased the spore burden at least by one order of magnitude in all groups. These results demonstrate that the E. cuniculi genotype III infection had a progressive course and surprisingly, Albendazole treatment had only a minimal effect. The E. cuniculi genotype III spore burden in individual organs reached up to 108 or 109 in immunocompetent or immunodeficient mice, respectively; however, these mice did not demonstrate any obvious clinical signs of microsporidiosis, and the immunodeficient mice survived longer. Our findings clearly show that the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view.

Authors+Show Affiliations

Institute of Parasitology, Biology Centre, Czech Academy of Science, České Budějovice, Czech Republic. Electronic address: casio@paru.cas.cz.Institute of Parasitology, Biology Centre, Czech Academy of Science, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia in České Budějovice, České Budějovice, Czech Republic.Institute of Parasitology, Biology Centre, Czech Academy of Science, České Budějovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, České Budějovice, Czech Republic.Institute of Parasitology, Biology Centre, Czech Academy of Science, České Budějovice, Czech Republic.Institute of Parasitology, Biology Centre, Czech Academy of Science, České Budějovice, Czech Republic.Institute of Parasitology, Biology Centre, Czech Academy of Science, České Budějovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, České Budějovice, Czech Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32579904

Citation

Sak, Bohumil, et al. "A Massive Systematic Infection of Encephalitozoon Cuniculi Genotype III in Mice Does Not Cause Clinical Signs." Microbes and Infection, 2020.
Sak B, Brdíčková K, Holubová N, et al. A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs. Microbes Infect. 2020.
Sak, B., Brdíčková, K., Holubová, N., Květoňová, D., Hlásková, L., & Kváč, M. (2020). A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs. Microbes and Infection. https://doi.org/10.1016/j.micinf.2020.06.004
Sak B, et al. A Massive Systematic Infection of Encephalitozoon Cuniculi Genotype III in Mice Does Not Cause Clinical Signs. Microbes Infect. 2020 Jun 21; PubMed PMID: 32579904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs. AU - Sak,Bohumil, AU - Brdíčková,Klára, AU - Holubová,Nikola, AU - Květoňová,Dana, AU - Hlásková,Lenka, AU - Kváč,Martin, Y1 - 2020/06/21/ PY - 2020/03/27/received PY - 2020/06/03/revised PY - 2020/06/12/accepted PY - 2020/6/25/pubmed PY - 2020/6/25/medline PY - 2020/6/25/entrez KW - Albendazole KW - C57Bl/6 mice KW - CD4(−/−) mice KW - CD8(−/−) mice KW - Encephalitozoon cuniculi genotype III JF - Microbes and infection JO - Microbes Infect. N2 - Encephalitozoon cuniculi genotype III disseminated intensively into most of the organs in all strains of mice, followed by a chronic infection with massive microsporidia persistence in immunodeficient mice and a partial decrease in C57Bl/6 mice. Treatment with 0.2 mg Albendazole/mouse/day temporarily reduces the number of affected organs in immunocompetent C57Bl/6 mice, but not in CD4-/- and CD8-/- mice. The application of medication temporarily decreased the spore burden at least by one order of magnitude in all groups. These results demonstrate that the E. cuniculi genotype III infection had a progressive course and surprisingly, Albendazole treatment had only a minimal effect. The E. cuniculi genotype III spore burden in individual organs reached up to 108 or 109 in immunocompetent or immunodeficient mice, respectively; however, these mice did not demonstrate any obvious clinical signs of microsporidiosis, and the immunodeficient mice survived longer. Our findings clearly show that the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view. SN - 1769-714X UR - https://www.unboundmedicine.com/medline/citation/32579904/A_massive_systematic_infection_of_Encephalitozoon_cuniculi_genotype_III_in_mice_does_not_cause_clinical_signs L2 - https://linkinghub.elsevier.com/retrieve/pii/S1286-4579(20)30122-2 DB - PRIME DP - Unbound Medicine ER -
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