Tags

Type your tag names separated by a space and hit enter

Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases.
Biochem Pharmacol. 2020 Nov; 181:114107.BP

Abstract

Venom peptides are amongst the most exquisite group of bioactive molecules able to alter the normal physiology of organisms. These bioactive peptides penetrate tissues and blood vessels to encounter a number of receptors and ion channels to which they bind with high affinity and execute modulatory activities. Arachnid is the most diverse class of venomous animals often rich in peptides modulating voltage-gated sodium (NaV), calcium (CaV), and potassium (KV) channels. Spider venoms, in particular, contain potent and selective peptides targeting these channels, with a few displaying interesting multi-target properties for NaV and CaV channels underlying disease mechanisms such as in neuropathic pain, motor neuron disease and cancer. The elucidation of the pharmacology and structure-function properties of these venom peptides are invaluable for the development of effective drugs targeting NaV and CaV channels. This perspective discusses spider venom peptides displaying multi-target properties to modulate NaV and CaV channels in regard to their pharmacological features, structure-function relationships and potential to become the next generation of effective drugs to treat neurological disorders and other multi-ion channels related diseases.

Authors+Show Affiliations

Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Rd., St Lucia, QLD AU 4072, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32579958

Citation

Cardoso, Fernanda C.. "Multi-targeting Sodium and Calcium Channels Using Venom Peptides for the Treatment of Complex Ion Channels-related Diseases." Biochemical Pharmacology, vol. 181, 2020, p. 114107.
Cardoso FC. Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochem Pharmacol. 2020;181:114107.
Cardoso, F. C. (2020). Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochemical Pharmacology, 181, 114107. https://doi.org/10.1016/j.bcp.2020.114107
Cardoso FC. Multi-targeting Sodium and Calcium Channels Using Venom Peptides for the Treatment of Complex Ion Channels-related Diseases. Biochem Pharmacol. 2020;181:114107. PubMed PMID: 32579958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. A1 - Cardoso,Fernanda C, Y1 - 2020/06/21/ PY - 2020/05/08/received PY - 2020/06/13/revised PY - 2020/06/17/accepted PY - 2020/6/25/pubmed PY - 2020/6/25/medline PY - 2020/6/25/entrez KW - Diseases KW - Ion channels KW - Multi-target KW - Spider venom KW - Therapies KW - Venom peptides SP - 114107 EP - 114107 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 181 N2 - Venom peptides are amongst the most exquisite group of bioactive molecules able to alter the normal physiology of organisms. These bioactive peptides penetrate tissues and blood vessels to encounter a number of receptors and ion channels to which they bind with high affinity and execute modulatory activities. Arachnid is the most diverse class of venomous animals often rich in peptides modulating voltage-gated sodium (NaV), calcium (CaV), and potassium (KV) channels. Spider venoms, in particular, contain potent and selective peptides targeting these channels, with a few displaying interesting multi-target properties for NaV and CaV channels underlying disease mechanisms such as in neuropathic pain, motor neuron disease and cancer. The elucidation of the pharmacology and structure-function properties of these venom peptides are invaluable for the development of effective drugs targeting NaV and CaV channels. This perspective discusses spider venom peptides displaying multi-target properties to modulate NaV and CaV channels in regard to their pharmacological features, structure-function relationships and potential to become the next generation of effective drugs to treat neurological disorders and other multi-ion channels related diseases. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/32579958/Multi_targeting_sodium_and_calcium_channels_using_venom_peptides_for_the_treatment_of_complex_ion_channels_related_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(20)30343-9 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.