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Mortality and survival of COVID-19.
Epidemiol Infect. 2020 06 25; 148:e123.EI

Abstract

This study aims to identify the risk factors associated with mortality and survival of COVID-19 cases in a state of the Brazilian Northeast. It is a historical cohort with a secondary database of 2070 people that presented flu-like symptoms, sought health assistance in the state and tested positive to COVID-19 until 14 April 2020, only moderate and severe cases were hospitalised. The main outcome was death as a binary variable (yes/no). It also investigated the main factors related to mortality and survival of the disease. Time since the beginning of symptoms until death/end of the survey (14 April 2020) was the time variable of this study. Mortality was analysed by robust Poisson regression, and survival by Kaplan-Meier and Cox regression. From the 2070 people that tested positive to COVID-19, 131 (6.3%) died and 1939 (93.7%) survived, the overall survival probability was 87.7% from the 24th day of infection. Mortality was enhanced by the variables: elderly (HR 3.6; 95% CI 2.3-5.8; P < 0.001), neurological diseases (HR 3.9; 95% CI 1.9-7.8; P < 0.001), pneumopathies (HR 2.6; 95% CI 1.4-4.7; P < 0.001) and cardiovascular diseases (HR 8.9; 95% CI 5.4-14.5; P < 0.001). In conclusion, mortality by COVID-19 in Ceará is similar to countries with a large number of cases of the disease, although deaths occur later. Elderly people and comorbidities presented a greater risk of death.

Authors+Show Affiliations

Postgraduation Program in Clinical Care in Nursing and Health, Ceará State University, Fortaleza, Ceará, Brazil.Postgraduation Program in Clinical Care in Nursing and Health, Ceará State University, Fortaleza, Ceará, Brazil.Postgraduation Program in Clinical Care in Nursing and Health, Ceará State University, Fortaleza, Ceará, Brazil.Postgraduation Program in Clinical Care in Nursing and Health, Ceará State University, Fortaleza, Ceará, Brazil.Postgraduation Program in Clinical Care in Nursing and Health, Ceará State University, Fortaleza, Ceará, Brazil.Postgraduation Program in Clinical Care in Nursing and Health, Ceará State University, Fortaleza, Ceará, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32580809

Citation

Sousa, G J B., et al. "Mortality and Survival of COVID-19." Epidemiology and Infection, vol. 148, 2020, pp. e123.
Sousa GJB, Garces TS, Cestari VRF, et al. Mortality and survival of COVID-19. Epidemiol Infect. 2020;148:e123.
Sousa, G. J. B., Garces, T. S., Cestari, V. R. F., Florêncio, R. S., Moreira, T. M. M., & Pereira, M. L. D. (2020). Mortality and survival of COVID-19. Epidemiology and Infection, 148, e123. https://doi.org/10.1017/S0950268820001405
Sousa GJB, et al. Mortality and Survival of COVID-19. Epidemiol Infect. 2020 06 25;148:e123. PubMed PMID: 32580809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mortality and survival of COVID-19. AU - Sousa,G J B, AU - Garces,T S, AU - Cestari,V R F, AU - Florêncio,R S, AU - Moreira,T M M, AU - Pereira,M L D, Y1 - 2020/06/25/ PY - 2020/6/26/pubmed PY - 2020/7/29/medline PY - 2020/6/26/entrez KW - Brazil KW - COVID-19 KW - epidemiology KW - mortality KW - survival SP - e123 EP - e123 JF - Epidemiology and infection JO - Epidemiol Infect VL - 148 N2 - This study aims to identify the risk factors associated with mortality and survival of COVID-19 cases in a state of the Brazilian Northeast. It is a historical cohort with a secondary database of 2070 people that presented flu-like symptoms, sought health assistance in the state and tested positive to COVID-19 until 14 April 2020, only moderate and severe cases were hospitalised. The main outcome was death as a binary variable (yes/no). It also investigated the main factors related to mortality and survival of the disease. Time since the beginning of symptoms until death/end of the survey (14 April 2020) was the time variable of this study. Mortality was analysed by robust Poisson regression, and survival by Kaplan-Meier and Cox regression. From the 2070 people that tested positive to COVID-19, 131 (6.3%) died and 1939 (93.7%) survived, the overall survival probability was 87.7% from the 24th day of infection. Mortality was enhanced by the variables: elderly (HR 3.6; 95% CI 2.3-5.8; P < 0.001), neurological diseases (HR 3.9; 95% CI 1.9-7.8; P < 0.001), pneumopathies (HR 2.6; 95% CI 1.4-4.7; P < 0.001) and cardiovascular diseases (HR 8.9; 95% CI 5.4-14.5; P < 0.001). In conclusion, mortality by COVID-19 in Ceará is similar to countries with a large number of cases of the disease, although deaths occur later. Elderly people and comorbidities presented a greater risk of death. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/32580809/Mortality_and_survival_of_COVID_19_ L2 - https://www.cambridge.org/core/product/identifier/S0950268820001405/type/journal_article DB - PRIME DP - Unbound Medicine ER -