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Clinicopathological Characteristics and Prognostic Factors of Patients with Gastric Cancer Accompanying Neuroendocrine Differentiation (NEDGC).
Cancer Manag Res. 2020; 12:4217-4225.CM

Abstract

Aim

Gastric carcinoma with neuroendocrine differentiation (NEDGC) is a relatively rare pathologic diagnosis in clinical practice, which has no specific guidelines or treatment recommendations yet. In this study, we aim to investigate the clinicopathological characteristics and prognostic factors of this disease.

Patients and Methods

We retrospectively analyzed clinicopathological data from a series of 82 NEDGC patients who underwent surgery for gastrectomy at Huashan Hospital Fudan University between January 2007 and December 2018. Furthermore, a series of 50 cases were used to analyze 3-year overall survival (OS).

Results

Ages of the patients ranged from 26 to 83 years (M:F, 4.8:1). The majority of patients suffered from some symptoms (97.6%), as the most common one was abdominal pain (48.8%). Most of the tumors were ≥5 cm (53.7%), in the lower part of the stomach (47.5%), and with advanced T (87.8% ≥T3) and N (67.1% ≥N1) stage. As to the neuroendocrine markers, Syn showed a slight advantage on sensitivity than CgA (79.3 and 75.6%, respectively). The 3-year OS was 54%. Advanced T stage (≥T3) of the primary tumor, positive lymphovascular invasion (LVI), large tumor size (5.5cm), high neutrophil-to-lymphocyte ratio (NLR, 2.51), and low prealbumin level (173.87 mg/L) were associated with inferior OS based on the univariate analysis. Low preoperative hemoglobin level (113.87g/L), laparoscopic-assisted gastrectomy, and advanced N stage (N3) were three independent risk factors for 3-year OS of NEDGC patients in both univariate and multivariate analysis.

Conclusion

The TN staging system for gastric adenocarcinoma also has a prognostic value for NEDGC patients, while N3 stage works as an independent predictor of patients' survival. Since most of the NEDGC patients were in advanced stage, proper indications to perform operative laparoscopy should be selected.

Authors+Show Affiliations

Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32581593

Citation

Wang, Ya-Ping, et al. "Clinicopathological Characteristics and Prognostic Factors of Patients With Gastric Cancer Accompanying Neuroendocrine Differentiation (NEDGC)." Cancer Management and Research, vol. 12, 2020, pp. 4217-4225.
Wang YP, Hong J, Wang J, et al. Clinicopathological Characteristics and Prognostic Factors of Patients with Gastric Cancer Accompanying Neuroendocrine Differentiation (NEDGC). Cancer Manag Res. 2020;12:4217-4225.
Wang, Y. P., Hong, J., Wang, J., Bei, Y. B., Hao, H. K., & Hua, L. C. (2020). Clinicopathological Characteristics and Prognostic Factors of Patients with Gastric Cancer Accompanying Neuroendocrine Differentiation (NEDGC). Cancer Management and Research, 12, 4217-4225. https://doi.org/10.2147/CMAR.S253175
Wang YP, et al. Clinicopathological Characteristics and Prognostic Factors of Patients With Gastric Cancer Accompanying Neuroendocrine Differentiation (NEDGC). Cancer Manag Res. 2020;12:4217-4225. PubMed PMID: 32581593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathological Characteristics and Prognostic Factors of Patients with Gastric Cancer Accompanying Neuroendocrine Differentiation (NEDGC). AU - Wang,Ya-Ping, AU - Hong,Jun, AU - Wang,Jian, AU - Bei,Yi-Bing, AU - Hao,Han-Kun, AU - Hua,Lu-Chun, Y1 - 2020/06/03/ PY - 2020/03/09/received PY - 2020/05/13/accepted PY - 2020/6/26/entrez PY - 2020/6/26/pubmed PY - 2020/6/26/medline KW - gastric cancer KW - neuroendocrine cell differentiation KW - prognosis KW - surgical treatment SP - 4217 EP - 4225 JF - Cancer management and research JO - Cancer Manag Res VL - 12 N2 - Aim: Gastric carcinoma with neuroendocrine differentiation (NEDGC) is a relatively rare pathologic diagnosis in clinical practice, which has no specific guidelines or treatment recommendations yet. In this study, we aim to investigate the clinicopathological characteristics and prognostic factors of this disease. Patients and Methods: We retrospectively analyzed clinicopathological data from a series of 82 NEDGC patients who underwent surgery for gastrectomy at Huashan Hospital Fudan University between January 2007 and December 2018. Furthermore, a series of 50 cases were used to analyze 3-year overall survival (OS). Results: Ages of the patients ranged from 26 to 83 years (M:F, 4.8:1). The majority of patients suffered from some symptoms (97.6%), as the most common one was abdominal pain (48.8%). Most of the tumors were ≥5 cm (53.7%), in the lower part of the stomach (47.5%), and with advanced T (87.8% ≥T3) and N (67.1% ≥N1) stage. As to the neuroendocrine markers, Syn showed a slight advantage on sensitivity than CgA (79.3 and 75.6%, respectively). The 3-year OS was 54%. Advanced T stage (≥T3) of the primary tumor, positive lymphovascular invasion (LVI), large tumor size (5.5cm), high neutrophil-to-lymphocyte ratio (NLR, 2.51), and low prealbumin level (173.87 mg/L) were associated with inferior OS based on the univariate analysis. Low preoperative hemoglobin level (113.87g/L), laparoscopic-assisted gastrectomy, and advanced N stage (N3) were three independent risk factors for 3-year OS of NEDGC patients in both univariate and multivariate analysis. Conclusion: The TN staging system for gastric adenocarcinoma also has a prognostic value for NEDGC patients, while N3 stage works as an independent predictor of patients' survival. Since most of the NEDGC patients were in advanced stage, proper indications to perform operative laparoscopy should be selected. SN - 1179-1322 UR - https://www.unboundmedicine.com/medline/citation/32581593/Clinicopathological_Characteristics_and_Prognostic_Factors_of_Patients_with_Gastric_Cancer_Accompanying_Neuroendocrine_Differentiation_(NEDGC) L2 - https://dx.doi.org/10.2147/CMAR.S253175 DB - PRIME DP - Unbound Medicine ER -
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