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Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development.
Front Mol Neurosci. 2020; 13:99.FM

Abstract

The role of ion channels in neurons and muscles has been well characterized. However, recent work has demonstrated both the presence and necessity of ion channels in diverse cell types for morphological development. For example, mutations that disrupt ion channels give rise to abnormal structural development in species of flies, frogs, fish, mice, and humans. Furthermore, medications and recreational drugs that target ion channels are associated with higher incidence of birth defects in humans. In this review we establish the effects of several teratogens on development including epilepsy treatment drugs (topiramate, valproate, ethosuximide, phenobarbital, phenytoin, and carbamazepine), nicotine, heat, and cannabinoids. We then propose potential links between these teratogenic agents and ion channels with mechanistic insights from model organisms. Finally, we talk about the role of a particular ion channel, Kir2.1, in the formation and development of bone as an example of how ion channels can be used to uncover important processes in morphogenesis. Because ion channels are common targets of many currently used medications, understanding how ion channels impact morphological development will be important for prevention of birth defects. It is becoming increasingly clear that ion channels have functional roles outside of tissues that have been classically considered excitable.

Authors+Show Affiliations

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32581710

Citation

Ozekin, Yunus H., et al. "Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development." Frontiers in Molecular Neuroscience, vol. 13, 2020, p. 99.
Ozekin YH, Isner T, Bates EA. Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development. Front Mol Neurosci. 2020;13:99.
Ozekin, Y. H., Isner, T., & Bates, E. A. (2020). Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development. Frontiers in Molecular Neuroscience, 13, 99. https://doi.org/10.3389/fnmol.2020.00099
Ozekin YH, Isner T, Bates EA. Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development. Front Mol Neurosci. 2020;13:99. PubMed PMID: 32581710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development. AU - Ozekin,Yunus H, AU - Isner,Trevor, AU - Bates,Emily A, Y1 - 2020/06/09/ PY - 2020/02/15/received PY - 2020/05/08/accepted PY - 2020/6/26/entrez PY - 2020/6/26/pubmed PY - 2020/6/26/medline KW - bioelectricity KW - ion channel KW - nicotine KW - skeletal development KW - teratogen SP - 99 EP - 99 JF - Frontiers in molecular neuroscience JO - Front Mol Neurosci VL - 13 N2 - The role of ion channels in neurons and muscles has been well characterized. However, recent work has demonstrated both the presence and necessity of ion channels in diverse cell types for morphological development. For example, mutations that disrupt ion channels give rise to abnormal structural development in species of flies, frogs, fish, mice, and humans. Furthermore, medications and recreational drugs that target ion channels are associated with higher incidence of birth defects in humans. In this review we establish the effects of several teratogens on development including epilepsy treatment drugs (topiramate, valproate, ethosuximide, phenobarbital, phenytoin, and carbamazepine), nicotine, heat, and cannabinoids. We then propose potential links between these teratogenic agents and ion channels with mechanistic insights from model organisms. Finally, we talk about the role of a particular ion channel, Kir2.1, in the formation and development of bone as an example of how ion channels can be used to uncover important processes in morphogenesis. Because ion channels are common targets of many currently used medications, understanding how ion channels impact morphological development will be important for prevention of birth defects. It is becoming increasingly clear that ion channels have functional roles outside of tissues that have been classically considered excitable. SN - 1662-5099 UR - https://www.unboundmedicine.com/medline/citation/32581710/Ion_Channel_Contributions_to_Morphological_Development:_Insights_From_the_Role_of_Kir2.1_in_Bone_Development L2 - https://doi.org/10.3389/fnmol.2020.00099 DB - PRIME DP - Unbound Medicine ER -
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