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Alterations of Interhemispheric Functional Connectivity in Parkinson's Disease With Depression: A Resting-State Functional MRI Study.
Front Hum Neurosci. 2020; 14:193.FH

Abstract

Background

Depression is the most common non-motor symptom in patients with Parkinson's disease (PD) with unknown mechanisms, but the diagnostic criteria of PD with depression (PDD) are not uniform.

Purpose

The aim of the study was to investigate interhemispheric interactions between PDD patients and patients with PD without depression (PDND).

Methods

The voxel-mirrored homotopic connectivity (VMHC) combined with the seed-based method was used to investigate intrinsic resting-state functional connectivity (RSFC) in 33 PDD patients, 60 PDND, and 47 healthy controls (HCs).

Results

PDD patients exhibited a decreased VMHC in the bilateral medial frontal gyrus and paracentral lobule (MFG/PCL) than did PDND patients. Parkinson's disease with depression had a decreased VMHC in the bilateral precentral gyrus than had PDND and HC (p < 0.05). Parkinson's disease with depression had a decreased homotopic RSFC from the medial frontal gyrus (MFG)/PCL to the contralateral supplementary motor area (SMA) than had PDND (p < 0.05). The decreased homotopic RSFC from the right MFG/PCL to the left SMA was negatively correlated with Hamilton Depression Rating Scale scores (p < 0.05), but not with illness duration, Beck's Depression Inventory, and Unified Parkinson's Disease Rating Scale in PD patients.

Conclusions

Our findings indicated that the occurrence of depression in Parkinson's disease is associated with the dysfunctional connectivity from the MFG/PCL to the contralateral SMA, which could be used as potential neuroimaging markers for the diagnosis of depression in PD patients.

Authors+Show Affiliations

Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32581743

Citation

Liao, Haiyan, et al. "Alterations of Interhemispheric Functional Connectivity in Parkinson's Disease With Depression: a Resting-State Functional MRI Study." Frontiers in Human Neuroscience, vol. 14, 2020, p. 193.
Liao H, Fan J, Shen Q, et al. Alterations of Interhemispheric Functional Connectivity in Parkinson's Disease With Depression: A Resting-State Functional MRI Study. Front Hum Neurosci. 2020;14:193.
Liao, H., Fan, J., Shen, Q., Cai, S., Wang, M., Wang, C., Zhang, H., Liu, J., Zhu, X., & Tan, C. (2020). Alterations of Interhemispheric Functional Connectivity in Parkinson's Disease With Depression: A Resting-State Functional MRI Study. Frontiers in Human Neuroscience, 14, 193. https://doi.org/10.3389/fnhum.2020.00193
Liao H, et al. Alterations of Interhemispheric Functional Connectivity in Parkinson's Disease With Depression: a Resting-State Functional MRI Study. Front Hum Neurosci. 2020;14:193. PubMed PMID: 32581743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations of Interhemispheric Functional Connectivity in Parkinson's Disease With Depression: A Resting-State Functional MRI Study. AU - Liao,Haiyan, AU - Fan,Jie, AU - Shen,Qin, AU - Cai,Sainan, AU - Wang,Min, AU - Wang,Chunyu, AU - Zhang,Hainan, AU - Liu,Jun, AU - Zhu,Xiongzhao, AU - Tan,Changlian, Y1 - 2020/06/05/ PY - 2020/01/30/received PY - 2020/04/28/accepted PY - 2020/6/26/entrez PY - 2020/6/26/pubmed PY - 2020/6/26/medline KW - Parkinson’s disease KW - depression KW - functional connectivity KW - resting state KW - voxel-mirrored homotopic connectivity SP - 193 EP - 193 JF - Frontiers in human neuroscience JO - Front Hum Neurosci VL - 14 N2 - Background: Depression is the most common non-motor symptom in patients with Parkinson's disease (PD) with unknown mechanisms, but the diagnostic criteria of PD with depression (PDD) are not uniform. Purpose: The aim of the study was to investigate interhemispheric interactions between PDD patients and patients with PD without depression (PDND). Methods: The voxel-mirrored homotopic connectivity (VMHC) combined with the seed-based method was used to investigate intrinsic resting-state functional connectivity (RSFC) in 33 PDD patients, 60 PDND, and 47 healthy controls (HCs). Results: PDD patients exhibited a decreased VMHC in the bilateral medial frontal gyrus and paracentral lobule (MFG/PCL) than did PDND patients. Parkinson's disease with depression had a decreased VMHC in the bilateral precentral gyrus than had PDND and HC (p < 0.05). Parkinson's disease with depression had a decreased homotopic RSFC from the medial frontal gyrus (MFG)/PCL to the contralateral supplementary motor area (SMA) than had PDND (p < 0.05). The decreased homotopic RSFC from the right MFG/PCL to the left SMA was negatively correlated with Hamilton Depression Rating Scale scores (p < 0.05), but not with illness duration, Beck's Depression Inventory, and Unified Parkinson's Disease Rating Scale in PD patients. Conclusions: Our findings indicated that the occurrence of depression in Parkinson's disease is associated with the dysfunctional connectivity from the MFG/PCL to the contralateral SMA, which could be used as potential neuroimaging markers for the diagnosis of depression in PD patients. SN - 1662-5161 UR - https://www.unboundmedicine.com/medline/citation/32581743/Alterations_of_Interhemispheric_Functional_Connectivity_in_Parkinson's_Disease_With_Depression:_A_Resting_State_Functional_MRI_Study_ L2 - https://doi.org/10.3389/fnhum.2020.00193 DB - PRIME DP - Unbound Medicine ER -
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