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Knowledge Mapping of Drug-Induced Liver Injury: A Scientometric Investigation (2010-2019).
Front Pharmacol. 2020; 11:842.FP

Abstract

Background

Drug-induced liver injury (DILI) is a common adverse event, which compromises the safety of numerous drugs, poses a significant risk to patient health, and enhances healthcare expenditures. Many articles have been recently published on DILI related research, though no relevant scientometric study has been published yet. This scientometric study was aimed at comprehensively analyzing the knowledge base and emerging topics on DILI.

Methods

The articles and reviews related to DILI, published from 2010 to 2019 in the Web of Science Core Collection (WoSCC), were retrieved on March 15, 2020, using relevant keywords. Four different scientometric software (HistCite, VOSviewer, CiteSpace, and R-bibliometrix) was used to conduct this scientometric study.

Results

A total of 1,995 publications were retrieved (including 1,550 articles and 445 reviews) from 592 academic journals with 56,273 co-cited references in 10 languages by 2,331 institutions from 79 countries/regions. The majority of publications (n = 727, 36.44%) were published in the United States, and the University of North Carolina contributed the most publications (n = 89, 4.46%). The most productive academic journal on DILI was the Toxicological Sciences [n = 79, 3.96%; impact factor (IF) 2018 = 3.564], and Hepatology was the first co-cited journal (n = 7,383, IF 2018 = 14.971). Fontana RJ and Teschke R may have significant influence on DILI research, with more publications (n = 46; n = 39) and co-citations (n = 382; n = 945). Definition, incidence rate or clinical characteristics, etiology or pathogenesis (such as the character of the innate immune system, the regulation of cell-death pathways, and susceptible HLA-B*5701 genotype), identification of main drugs and causality assessment (criteria and methods) were the knowledge base for DILI research. Exploring the microscopic mechanism (such as the organelle dysfunction and cytotoxicity induced by drugs, and exploration of role of neutrophils in DILI using mouse models) and developed newer approaches to prevent DILI (such as the prospective HLA-B*5701 screening and in vitro approaches for assessing the potential risk of candidate drugs for DILI) were the recent major topics for DILI research.

Conclusion

This scientometric study comprehensively reviewed the publications related to DILI during the past decade using quantitative and qualitative methods. This information would provide references for scholars, researching on DILI.

Authors+Show Affiliations

Department of Liver Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.Department of Liver Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.Key Laboratory of Preclinical Study for New Drug of Gansu Province, School of Basic Medical Science, Lanzhou University, Lanzhou, China.Department of Liver Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32581801

Citation

Ke, Lixin, et al. "Knowledge Mapping of Drug-Induced Liver Injury: a Scientometric Investigation (2010-2019)." Frontiers in Pharmacology, vol. 11, 2020, p. 842.
Ke L, Lu C, Shen R, et al. Knowledge Mapping of Drug-Induced Liver Injury: A Scientometric Investigation (2010-2019). Front Pharmacol. 2020;11:842.
Ke, L., Lu, C., Shen, R., Lu, T., Ma, B., & Hua, Y. (2020). Knowledge Mapping of Drug-Induced Liver Injury: A Scientometric Investigation (2010-2019). Frontiers in Pharmacology, 11, 842. https://doi.org/10.3389/fphar.2020.00842
Ke L, et al. Knowledge Mapping of Drug-Induced Liver Injury: a Scientometric Investigation (2010-2019). Front Pharmacol. 2020;11:842. PubMed PMID: 32581801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Knowledge Mapping of Drug-Induced Liver Injury: A Scientometric Investigation (2010-2019). AU - Ke,Lixin, AU - Lu,Cuncun, AU - Shen,Rui, AU - Lu,Tingting, AU - Ma,Bin, AU - Hua,Yunpeng, Y1 - 2020/06/05/ PY - 2020/04/14/received PY - 2020/05/22/accepted PY - 2020/6/26/entrez PY - 2020/6/26/pubmed PY - 2020/6/26/medline KW - CiteSpace KW - HLA-B*5701 KW - VOSviewer KW - drug-induced liver injury KW - scientometric SP - 842 EP - 842 JF - Frontiers in pharmacology JO - Front Pharmacol VL - 11 N2 - Background: Drug-induced liver injury (DILI) is a common adverse event, which compromises the safety of numerous drugs, poses a significant risk to patient health, and enhances healthcare expenditures. Many articles have been recently published on DILI related research, though no relevant scientometric study has been published yet. This scientometric study was aimed at comprehensively analyzing the knowledge base and emerging topics on DILI. Methods: The articles and reviews related to DILI, published from 2010 to 2019 in the Web of Science Core Collection (WoSCC), were retrieved on March 15, 2020, using relevant keywords. Four different scientometric software (HistCite, VOSviewer, CiteSpace, and R-bibliometrix) was used to conduct this scientometric study. Results: A total of 1,995 publications were retrieved (including 1,550 articles and 445 reviews) from 592 academic journals with 56,273 co-cited references in 10 languages by 2,331 institutions from 79 countries/regions. The majority of publications (n = 727, 36.44%) were published in the United States, and the University of North Carolina contributed the most publications (n = 89, 4.46%). The most productive academic journal on DILI was the Toxicological Sciences [n = 79, 3.96%; impact factor (IF) 2018 = 3.564], and Hepatology was the first co-cited journal (n = 7,383, IF 2018 = 14.971). Fontana RJ and Teschke R may have significant influence on DILI research, with more publications (n = 46; n = 39) and co-citations (n = 382; n = 945). Definition, incidence rate or clinical characteristics, etiology or pathogenesis (such as the character of the innate immune system, the regulation of cell-death pathways, and susceptible HLA-B*5701 genotype), identification of main drugs and causality assessment (criteria and methods) were the knowledge base for DILI research. Exploring the microscopic mechanism (such as the organelle dysfunction and cytotoxicity induced by drugs, and exploration of role of neutrophils in DILI using mouse models) and developed newer approaches to prevent DILI (such as the prospective HLA-B*5701 screening and in vitro approaches for assessing the potential risk of candidate drugs for DILI) were the recent major topics for DILI research. Conclusion: This scientometric study comprehensively reviewed the publications related to DILI during the past decade using quantitative and qualitative methods. This information would provide references for scholars, researching on DILI. SN - 1663-9812 UR - https://www.unboundmedicine.com/medline/citation/32581801/Knowledge_Mapping_of_Drug_Induced_Liver_Injury:_A_Scientometric_Investigation__2010_2019__ L2 - https://doi.org/10.3389/fphar.2020.00842 DB - PRIME DP - Unbound Medicine ER -
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