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Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin by Convolutional Neural Networks.
Front Med (Lausanne). 2020; 7:220.FM

Abstract

Optical coherence tomography (OCT) is a well-established bedside imaging modality that allows analysis of skin structures in a non-invasive way. Automated OCT analysis of skin layers is of great relevance to study dermatological diseases. In this paper, an approach to detect the epidermal layer along with the follicular structures in healthy human OCT images is presented. To the best of the authors' knowledge, the approach presented in this paper is the only epidermis detection algorithm that segments the pilosebaceous unit, which is of importance in the progression of several skin disorders such as folliculitis, acne, lupus erythematosus, and basal cell carcinoma. The proposed approach is composed of two main stages. The first stage is a Convolutional Neural Network based on U-Net architecture. The second stage is a robust post-processing composed by a Savitzky-Golay filter and Fourier Domain Filtering to fully define the borders belonging to the hair follicles. After validation, an average Dice of 0.83 ± 0.06 and a thickness error of 10.25 μm is obtained on 270 human skin OCT images. Based on these results, the proposed method outperforms other state-of-the-art methods for epidermis segmentation. It demonstrates that the proposed image segmentation method successfully detects the epidermal region in a fully automatic way in addition to defining the follicular skin structures as main novelty.

Authors+Show Affiliations

Instituto de Investigación e Innovación en Bioingeniería, I3B, Universitat Politècnica de València, Valencia, Spain.Instituto de Investigación e Innovación en Bioingeniería, I3B, Universitat Politècnica de València, Valencia, Spain.Instituto de Investigación e Innovación en Bioingeniería, I3B, Universitat Politècnica de València, Valencia, Spain.Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.Instituto de Investigación e Innovación en Bioingeniería, I3B, Universitat Politècnica de València, Valencia, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32582729

Citation

Del Amor, Rocío, et al. "Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin By Convolutional Neural Networks." Frontiers in Medicine, vol. 7, 2020, p. 220.
Del Amor R, Morales S, Colomer A, et al. Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin by Convolutional Neural Networks. Front Med (Lausanne). 2020;7:220.
Del Amor, R., Morales, S., Colomer, A., Mogensen, M., Jensen, M., Israelsen, N. M., Bang, O., & Naranjo, V. (2020). Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin by Convolutional Neural Networks. Frontiers in Medicine, 7, 220. https://doi.org/10.3389/fmed.2020.00220
Del Amor R, et al. Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin By Convolutional Neural Networks. Front Med (Lausanne). 2020;7:220. PubMed PMID: 32582729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin by Convolutional Neural Networks. AU - Del Amor,Rocío, AU - Morales,Sandra, AU - Colomer,Adrián, AU - Mogensen,Mette, AU - Jensen,Mikkel, AU - Israelsen,Niels M, AU - Bang,Ole, AU - Naranjo,Valery, Y1 - 2020/06/04/ PY - 2020/03/03/received PY - 2020/05/01/accepted PY - 2020/6/26/entrez PY - 2020/6/26/pubmed PY - 2020/6/26/medline KW - convolutional neural networks KW - epidermis KW - follicular structures KW - layer segmentation KW - pilosebaceous unit KW - skin OCT SP - 220 EP - 220 JF - Frontiers in medicine JO - Front Med (Lausanne) VL - 7 N2 - Optical coherence tomography (OCT) is a well-established bedside imaging modality that allows analysis of skin structures in a non-invasive way. Automated OCT analysis of skin layers is of great relevance to study dermatological diseases. In this paper, an approach to detect the epidermal layer along with the follicular structures in healthy human OCT images is presented. To the best of the authors' knowledge, the approach presented in this paper is the only epidermis detection algorithm that segments the pilosebaceous unit, which is of importance in the progression of several skin disorders such as folliculitis, acne, lupus erythematosus, and basal cell carcinoma. The proposed approach is composed of two main stages. The first stage is a Convolutional Neural Network based on U-Net architecture. The second stage is a robust post-processing composed by a Savitzky-Golay filter and Fourier Domain Filtering to fully define the borders belonging to the hair follicles. After validation, an average Dice of 0.83 ± 0.06 and a thickness error of 10.25 μm is obtained on 270 human skin OCT images. Based on these results, the proposed method outperforms other state-of-the-art methods for epidermis segmentation. It demonstrates that the proposed image segmentation method successfully detects the epidermal region in a fully automatic way in addition to defining the follicular skin structures as main novelty. SN - 2296-858X UR - https://www.unboundmedicine.com/medline/citation/32582729/Automatic_Segmentation_of_Epidermis_and_Hair_Follicles_in_Optical_Coherence_Tomography_Images_of_Normal_Skin_by_Convolutional_Neural_Networks L2 - https://doi.org/10.3389/fmed.2020.00220 DB - PRIME DP - Unbound Medicine ER -
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