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Androgen Receptor Expression In Endometrial Carcinoma And Its Correlation With Estrogen Receptor And Progesterone Receptor And Clinicopathological Findings.
J Ayub Med Coll Abbottabad. 2020 Apr- Jun; 32(2):160-164.JA

Abstract

BACKGROUND

The objective of the study is to analyze the expression of androgen, estrogen and progesterone receptor in different types of endometrial carcinomas and to correlate the androgen receptor expression with estrogen and progesterone receptor and the clinicopathological parameters like lymphovascular invasion, grade of the tumour, size of tumour and extent of myometrial invasion..

METHODS

It is a cross-sectional analytical study design with a simple random sample of a total of 54 cases of different types of endometrial carcinomas from the year 2017. Immunohistochemical stains androgen receptor, estrogen receptor, and Progesterone receptor were applied in all the cases. The Pearson Chi-square test of independence was applied to measure association and P-value is calculated to check the significance of the results.

RESULTS

Androgen receptor expression was observed in 73% of low-grade endometrioid carcinomas, 62.5% of high-grade endometrioid carcinomas, 62% of serous, 20% of clear cell and 18% of carcinosarcomas, respectively. Androgen positive tumours were also positive for estrogen and progesterone in most of the cases, except 3 serous carcinomas and one low-grade endometrioid carcinoma. However, no significant relation was observed between androgen expression and prognostic parameters like the lymphovascular invasion, size of the tumour and myometrial invasion.

CONCLUSIONS

Maximum expression of androgen receptor was observed in endometrioid and serous carcinomas, while carcinosarcomas and clear cell carcinomas showed minimum expression with no significant correlation between androgen receptor expression and clinicopathological parameters.

Authors+Show Affiliations

Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan.Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan.Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan.Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan.Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32583986

Citation

Nisar, Maryam, et al. "Androgen Receptor Expression in Endometrial Carcinoma and Its Correlation With Estrogen Receptor and Progesterone Receptor and Clinicopathological Findings." Journal of Ayub Medical College, Abbottabad : JAMC, vol. 32, no. 2, 2020, pp. 160-164.
Nisar M, Mushtaq S, Hassan U, et al. Androgen Receptor Expression In Endometrial Carcinoma And Its Correlation With Estrogen Receptor And Progesterone Receptor And Clinicopathological Findings. J Ayub Med Coll Abbottabad. 2020;32(2):160-164.
Nisar, M., Mushtaq, S., Hassan, U., Akhtar, N., & Azma, M. (2020). Androgen Receptor Expression In Endometrial Carcinoma And Its Correlation With Estrogen Receptor And Progesterone Receptor And Clinicopathological Findings. Journal of Ayub Medical College, Abbottabad : JAMC, 32(2), 160-164.
Nisar M, et al. Androgen Receptor Expression in Endometrial Carcinoma and Its Correlation With Estrogen Receptor and Progesterone Receptor and Clinicopathological Findings. J Ayub Med Coll Abbottabad. 2020 Apr- Jun;32(2):160-164. PubMed PMID: 32583986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgen Receptor Expression In Endometrial Carcinoma And Its Correlation With Estrogen Receptor And Progesterone Receptor And Clinicopathological Findings. AU - Nisar,Maryam, AU - Mushtaq,Sajid, AU - Hassan,Usman, AU - Akhtar,Noreen, AU - Azma,Muhammad, PY - 2020/6/26/entrez KW - Androgen receptor;Immunohistochemical stains KW - Endometrioid carcinoma KW - Serous carcinoma; Clear cell carcinoma SP - 160 EP - 164 JF - Journal of Ayub Medical College, Abbottabad : JAMC JO - J Ayub Med Coll Abbottabad VL - 32 IS - 2 N2 - BACKGROUND: The objective of the study is to analyze the expression of androgen, estrogen and progesterone receptor in different types of endometrial carcinomas and to correlate the androgen receptor expression with estrogen and progesterone receptor and the clinicopathological parameters like lymphovascular invasion, grade of the tumour, size of tumour and extent of myometrial invasion.. METHODS: It is a cross-sectional analytical study design with a simple random sample of a total of 54 cases of different types of endometrial carcinomas from the year 2017. Immunohistochemical stains androgen receptor, estrogen receptor, and Progesterone receptor were applied in all the cases. The Pearson Chi-square test of independence was applied to measure association and P-value is calculated to check the significance of the results. RESULTS: Androgen receptor expression was observed in 73% of low-grade endometrioid carcinomas, 62.5% of high-grade endometrioid carcinomas, 62% of serous, 20% of clear cell and 18% of carcinosarcomas, respectively. Androgen positive tumours were also positive for estrogen and progesterone in most of the cases, except 3 serous carcinomas and one low-grade endometrioid carcinoma. However, no significant relation was observed between androgen expression and prognostic parameters like the lymphovascular invasion, size of the tumour and myometrial invasion. CONCLUSIONS: Maximum expression of androgen receptor was observed in endometrioid and serous carcinomas, while carcinosarcomas and clear cell carcinomas showed minimum expression with no significant correlation between androgen receptor expression and clinicopathological parameters. SN - 1819-2718 UR - https://www.unboundmedicine.com/medline/citation/32583986/Androgen_Receptor_Expression_In_Endometrial_Carcinoma_And_Its_Correlation_With_Estrogen_Receptor_And_Progesterone_Receptor_And_Clinicopathological_Findings L2 - http://jamc.ayubmed.edu.pk/index.php/jamc/article/view/6524/2869 DB - PRIME DP - Unbound Medicine ER -
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