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Efficacy Of Preoperative Misoprostol In Reducing Hemorrhage During Abdominal Myomectomy.
J Ayub Med Coll Abbottabad. 2020 Apr- Jun; 32(2):198-203.JA

Abstract

BACKGROUND

Uterine myomas are most common non-cancerous tumours in reproductive period. The fertility preserving surgery, i.e., myomectomy as compared to hysterectomy, is associated with massive blood loss due to dissection of huge fibroids making it technically difficult procedure. Misoprostol (a uterotonic) is an effective option amongst different interventions used to reduce intraoperative blood loss during myomectomy. This randomized control trial investigated effectiveness of single dose of rectal misoprostol given preoperatively in reducing intraoperative blood loss during abdominal myomectomy..

METHODS

Fifty Patients undergoing abdominal myomectomy were selected for the study. Twenty-five patients were given 800 micrograms misoprostol per rectally half an hour before surgery while rest received placebo, i.e., control group. Number and weight of surgical packs were recorded both Pre and post operatively to assess blood loss. Preoperative and 24 hrs postoperative haemoglobin was also recorded. Data analysed by SPSS-20.

RESULTS

Mean of age, parity and myoma size were not statistically different between the two groups. However intraoperative blood loss (as measured by weighing and counting number of swabs used) and postoperative haemoglobin after 24 hours were significantly different between two groups with p-value <0.01.

CONCLUSIONS

Single dose of misoprostol given preoperatively via rectal route is effective in reducing intraoperative blood loss during abdominal myomectomy. Misoprostol must be used in different doses and routes in order to investigate its effectiveness in reducing intraoperative blood loss.

Authors+Show Affiliations

Department of Gynaecology & Obstetrics, Lady Reading Hospital Peshawar, Pakistan.Department of Gynaecology & Obstetrics, Lady Reading Hospital Peshawar, Pakistan.Department of Gynaecology & Obstetrics, Lady Reading Hospital Peshawar, Pakistan.Department of Gynaecology & Obstetrics, Lady Reading Hospital Peshawar, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32583994

Citation

Khan, Qudsia Qazi, et al. "Efficacy of Preoperative Misoprostol in Reducing Hemorrhage During Abdominal Myomectomy." Journal of Ayub Medical College, Abbottabad : JAMC, vol. 32, no. 2, 2020, pp. 198-203.
Khan QQ, Liaqat N, Shafqat T, et al. Efficacy Of Preoperative Misoprostol In Reducing Hemorrhage During Abdominal Myomectomy. J Ayub Med Coll Abbottabad. 2020;32(2):198-203.
Khan, Q. Q., Liaqat, N., Shafqat, T., & Bawar, S. (2020). Efficacy Of Preoperative Misoprostol In Reducing Hemorrhage During Abdominal Myomectomy. Journal of Ayub Medical College, Abbottabad : JAMC, 32(2), 198-203.
Khan QQ, et al. Efficacy of Preoperative Misoprostol in Reducing Hemorrhage During Abdominal Myomectomy. J Ayub Med Coll Abbottabad. 2020 Apr- Jun;32(2):198-203. PubMed PMID: 32583994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy Of Preoperative Misoprostol In Reducing Hemorrhage During Abdominal Myomectomy. AU - Khan,Qudsia Qazi, AU - Liaqat,Nazia, AU - Shafqat,Tanveer, AU - Bawar,Shandana, PY - 2020/6/26/entrez KW - Abdominal myomectomy; Intra operative; Blood loss KW - Preoperative misoprostol SP - 198 EP - 203 JF - Journal of Ayub Medical College, Abbottabad : JAMC JO - J Ayub Med Coll Abbottabad VL - 32 IS - 2 N2 - BACKGROUND: Uterine myomas are most common non-cancerous tumours in reproductive period. The fertility preserving surgery, i.e., myomectomy as compared to hysterectomy, is associated with massive blood loss due to dissection of huge fibroids making it technically difficult procedure. Misoprostol (a uterotonic) is an effective option amongst different interventions used to reduce intraoperative blood loss during myomectomy. This randomized control trial investigated effectiveness of single dose of rectal misoprostol given preoperatively in reducing intraoperative blood loss during abdominal myomectomy.. METHODS: Fifty Patients undergoing abdominal myomectomy were selected for the study. Twenty-five patients were given 800 micrograms misoprostol per rectally half an hour before surgery while rest received placebo, i.e., control group. Number and weight of surgical packs were recorded both Pre and post operatively to assess blood loss. Preoperative and 24 hrs postoperative haemoglobin was also recorded. Data analysed by SPSS-20. RESULTS: Mean of age, parity and myoma size were not statistically different between the two groups. However intraoperative blood loss (as measured by weighing and counting number of swabs used) and postoperative haemoglobin after 24 hours were significantly different between two groups with p-value <0.01. CONCLUSIONS: Single dose of misoprostol given preoperatively via rectal route is effective in reducing intraoperative blood loss during abdominal myomectomy. Misoprostol must be used in different doses and routes in order to investigate its effectiveness in reducing intraoperative blood loss. SN - 1819-2718 UR - https://www.unboundmedicine.com/medline/citation/32583994/Efficacy_Of_Preoperative_Misoprostol_In_Reducing_Hemorrhage_During_Abdominal_Myomectomy L2 - http://jamc.ayubmed.edu.pk/index.php/jamc/article/view/6588/2877 DB - PRIME DP - Unbound Medicine ER -
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