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Development of classification criteria for hand osteoarthritis: comparative analyses of persons with and without hand osteoarthritis.
RMD Open. 2020 06; 6(2)RO

Abstract

OBJECTIVES

Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA.

METHODS

In a cross-sectional multi-centre international study, a convenience sample of patients from primary and secondary/tertiary care with a physician-based hand OA diagnosis (n = 128) were compared with controls with hand complaints due to inflammatory or non-inflammatory conditions (n = 70). We examined whether self-reported, clinical, radiographic and laboratory findings were associated with hand OA using logistic regression analyses. Discrimination between groups was assessed by calculating the area under receiver operating curves (AUC).

RESULTS

Strong associations with hand OA were observed for radiographic osteophytes (OR = 1.62, 95% CI 1.40 to 1.88) and joint space narrowing (JSN) (OR = 1.57, 95% CI 1.36 to 1.82) in the distal interphalangeal (DIP) joints with excellent discrimination (AUC = 0.82 for both). For osteophytes and JSN, we found acceptable discrimination between groups in the proximal interphalangeal joints (AUC = 0.77 and 0.78, respectively), but poorer discrimination in the first carpometacarpal joints (AUC = 0.67 and 0.63, respectively). Painful DIP joints were associated with hand OA, but were less able to discriminate between groups (AUC = 0.67). Age and family history of OA were positively associated with hand OA, whereas negative associations were found for pain, stiffness and soft tissue swelling in metacarpophalangeal joints, pain and marginal erosions in wrists, longer morning stiffness, inflammatory biomarkers and autoantibodies.

CONCLUSIONS

Differences in symptoms, clinical findings, radiographic changes and laboratory tests were found in patients with hand OA versus controls. Radiographic OA features, especially in DIP joints, were best suited to discriminate between groups.

Authors+Show Affiliations

Rheumatology, Diakonhjemmet Hospital, Oslo, Norway ida.haugen@diakonsyk.no.Rheumatology Section, Boston University School of Medicine, Boston, Massachusetts, USA. Arthritis Research UK Epidemiology Unit and National Institute for Health Research Biomedical Research Centre, The University of Manchester, Manchester, UK.Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK. Nottingham NIHR-BRC,Nottingham, UK.Department of Rheumatology, Hopital Saint-Antoine,Paris, France.Department of General Practice, Department of Orthopedics, Erasmus Medical Center, Rotterdam, Netherlands.Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. Frysja Medical Practice, Oslo, Norway.Rheumatology, Universidad Autonoma De Madrid, Madrid, Spain.Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.Rheumatology, Landspitali, Reykjavik, Iceland.Rheumatology, Leiden University Medical Center, Leiden, Netherlands.Faculty of Medicine Pierre & Marie Curie Paris VI, Hopital Saint-Antoine,Paris, France.Rheumatology Unit, Department of Medicine-DIMED, University of Padova School of Medicine and Surgery, Padova, Italy.Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Wien, Austria.Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Wien, Austria.Rheumatology, Leiden University Medical Center, Leiden, Netherlands.Rheumatology, University Hospital Ghent, Gent, Belgium.Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.Rheumatology, Leiden University Medical Center, Leiden, Netherlands.Rheumatology, Leiden University Medical Center, Leiden, Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32584781

Citation

Haugen, Ida K., et al. "Development of Classification Criteria for Hand Osteoarthritis: Comparative Analyses of Persons With and Without Hand Osteoarthritis." RMD Open, vol. 6, no. 2, 2020.
Haugen IK, Felson DT, Abhishek A, et al. Development of classification criteria for hand osteoarthritis: comparative analyses of persons with and without hand osteoarthritis. RMD Open. 2020;6(2).
Haugen, I. K., Felson, D. T., Abhishek, A., Berenbaum, F., Bierma-Zeinstra, S., Borgen, T., Herrero Beaumont, G., Ishimori, M., Jonsson, H., Kroon, F. P., Maheu, E., Ramonda, R., Ritschl, V., Stamm, T. A., van der Heijde, D., Wittoek, R., Greibrokk, E., Smeets, W., & Kloppenburg, M. (2020). Development of classification criteria for hand osteoarthritis: comparative analyses of persons with and without hand osteoarthritis. RMD Open, 6(2). https://doi.org/10.1136/rmdopen-2020-001265
Haugen IK, et al. Development of Classification Criteria for Hand Osteoarthritis: Comparative Analyses of Persons With and Without Hand Osteoarthritis. RMD Open. 2020;6(2) PubMed PMID: 32584781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of classification criteria for hand osteoarthritis: comparative analyses of persons with and without hand osteoarthritis. AU - Haugen,Ida K, AU - Felson,David T, AU - Abhishek,Abhishek, AU - Berenbaum,Francis, AU - Bierma-Zeinstra,Sita, AU - Borgen,Tove, AU - Herrero Beaumont,Gabriel, AU - Ishimori,Mariko, AU - Jonsson,Helgi, AU - Kroon,Féline Pb, AU - Maheu,Emmanuel, AU - Ramonda,Roberta, AU - Ritschl,Valentin, AU - Stamm,Tanja A, AU - van der Heijde,Desirée, AU - Wittoek,Ruth, AU - Greibrokk,Elsie, AU - Smeets,Wilma, AU - Kloppenburg,Margreet, PY - 2020/04/10/received PY - 2020/05/26/revised PY - 2020/05/31/accepted PY - 2020/6/26/pubmed PY - 2020/6/26/medline PY - 2020/6/26/entrez KW - Ankylosing Spondylitis KW - Anti-TNF KW - Chondrocalcinosis KW - Chondrocytes KW - Epidemiology KW - Gene Polymorphism KW - Hand Osteoarthritis KW - Knee Osteoarthritis KW - MRI KW - Osteoarthritis KW - Outcomes research KW - Patient perspective KW - Qualitative research KW - Rehabilitation KW - Spondyloarthritis KW - Ultrasonography JF - RMD open JO - RMD Open VL - 6 IS - 2 N2 - OBJECTIVES: Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA. METHODS: In a cross-sectional multi-centre international study, a convenience sample of patients from primary and secondary/tertiary care with a physician-based hand OA diagnosis (n = 128) were compared with controls with hand complaints due to inflammatory or non-inflammatory conditions (n = 70). We examined whether self-reported, clinical, radiographic and laboratory findings were associated with hand OA using logistic regression analyses. Discrimination between groups was assessed by calculating the area under receiver operating curves (AUC). RESULTS: Strong associations with hand OA were observed for radiographic osteophytes (OR = 1.62, 95% CI 1.40 to 1.88) and joint space narrowing (JSN) (OR = 1.57, 95% CI 1.36 to 1.82) in the distal interphalangeal (DIP) joints with excellent discrimination (AUC = 0.82 for both). For osteophytes and JSN, we found acceptable discrimination between groups in the proximal interphalangeal joints (AUC = 0.77 and 0.78, respectively), but poorer discrimination in the first carpometacarpal joints (AUC = 0.67 and 0.63, respectively). Painful DIP joints were associated with hand OA, but were less able to discriminate between groups (AUC = 0.67). Age and family history of OA were positively associated with hand OA, whereas negative associations were found for pain, stiffness and soft tissue swelling in metacarpophalangeal joints, pain and marginal erosions in wrists, longer morning stiffness, inflammatory biomarkers and autoantibodies. CONCLUSIONS: Differences in symptoms, clinical findings, radiographic changes and laboratory tests were found in patients with hand OA versus controls. Radiographic OA features, especially in DIP joints, were best suited to discriminate between groups. SN - 2056-5933 UR - https://www.unboundmedicine.com/medline/citation/32584781/Development_of_classification_criteria_for_hand_osteoarthritis:_comparative_analyses_of_persons_with_and_without_hand_osteoarthritis L2 - https://rmdopen.bmj.com/cgi/pmidlookup?view=long&pmid=32584781 DB - PRIME DP - Unbound Medicine ER -
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