Tags

Type your tag names separated by a space and hit enter

Ibuprofen in needle procedures in children with cancer-A feasibility and pilot study.
Acta Paediatr. 2020 Jun 25 [Online ahead of print]AP

Abstract

AIM

To investigate the feasibility, and perform a pilot study, of a randomised clinical trial, investigating whether children experience less pain, fear and/or distress when they receive oral ibuprofen vs placebo before a needle is inserted in a subcutaneously implanted intravenous port.

METHODS

Twenty-three children were included consecutively and randomised to either oral ibuprofen (n = 12) 7.5 mg/kg body weight or placebo (n = 11). The child's pain, fear and distress were reported by parents, nurses and the children (if ≥7 years of age). Feasibility criteria were defined as (a) ≥4 children included/month, (b) ≥80% of eligible patients agreed to participate, (c) >90% treated according to protocol, (d) <5% missing data, (e) s-cortisol samples analysed in ≥90% of the children.

RESULTS

All feasibility criteria were met except recruitment and consent. Parents, nurses and children reported no trend of benefit of oral ibuprofen with regard to pain, fear and distress compared with placebo.

CONCLUSION

The study failed to meet important feasibility criteria and was closed due to low recruitment rate and absence of trend of effect. From this data, we cannot state that ibuprofen is not helpful in needle procedures but that it seems unlikely.

Authors+Show Affiliations

Department of Women's and Children's Health, Pediatric Oncology, Uppsala University, Uppsala, Sweden.Department of Women's and Children's Health, Pediatric Oncology, Uppsala University, Uppsala, Sweden. Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, Sweden.Department of Women's and Children's Health, Clinical Psychology in Healthcare, Uppsala University, Uppsala, Sweden.Department of Women's and Children's Health, Pediatric Oncology, Uppsala University, Uppsala, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32585039

Citation

Kamsvåg, Tove, et al. "Ibuprofen in Needle Procedures in Children With cancer-A Feasibility and Pilot Study." Acta Paediatrica (Oslo, Norway : 1992), 2020.
Kamsvåg T, Hedén L, von Essen L, et al. Ibuprofen in needle procedures in children with cancer-A feasibility and pilot study. Acta Paediatr. 2020.
Kamsvåg, T., Hedén, L., von Essen, L., & Ljungman, G. (2020). Ibuprofen in needle procedures in children with cancer-A feasibility and pilot study. Acta Paediatrica (Oslo, Norway : 1992). https://doi.org/10.1111/apa.15449
Kamsvåg T, et al. Ibuprofen in Needle Procedures in Children With cancer-A Feasibility and Pilot Study. Acta Paediatr. 2020 Jun 25; PubMed PMID: 32585039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ibuprofen in needle procedures in children with cancer-A feasibility and pilot study. AU - Kamsvåg,Tove, AU - Hedén,Lena, AU - von Essen,Louise, AU - Ljungman,Gustaf, Y1 - 2020/06/25/ PY - 2020/05/08/received PY - 2020/06/22/revised PY - 2020/06/22/accepted PY - 2020/6/26/pubmed PY - 2020/6/26/medline PY - 2020/6/26/entrez KW - feasibility study KW - pediatric pain KW - procedural pain JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. N2 - AIM: To investigate the feasibility, and perform a pilot study, of a randomised clinical trial, investigating whether children experience less pain, fear and/or distress when they receive oral ibuprofen vs placebo before a needle is inserted in a subcutaneously implanted intravenous port. METHODS: Twenty-three children were included consecutively and randomised to either oral ibuprofen (n = 12) 7.5 mg/kg body weight or placebo (n = 11). The child's pain, fear and distress were reported by parents, nurses and the children (if ≥7 years of age). Feasibility criteria were defined as (a) ≥4 children included/month, (b) ≥80% of eligible patients agreed to participate, (c) >90% treated according to protocol, (d) <5% missing data, (e) s-cortisol samples analysed in ≥90% of the children. RESULTS: All feasibility criteria were met except recruitment and consent. Parents, nurses and children reported no trend of benefit of oral ibuprofen with regard to pain, fear and distress compared with placebo. CONCLUSION: The study failed to meet important feasibility criteria and was closed due to low recruitment rate and absence of trend of effect. From this data, we cannot state that ibuprofen is not helpful in needle procedures but that it seems unlikely. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/32585039/Ibuprofen_in_needle_procedures_in_children_with_cancer_-_a_feasibility_and_pilot_study L2 - https://doi.org/10.1111/apa.15449 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.