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Non-steroidal anti-inflammatory drugs increase urinary neutrophil gelatinase-associated lipocalin in recreational runners.
Scand J Med Sci Sports. 2020 Jun 25 [Online ahead of print]SJ

Abstract

OBJECTIVES

To study the effects of running with/without the use of pain killers on urinary neutrophil gelatinase-associated lipocalin (uNGAL) and other parameters of kidney function in recreational runners.

METHODS

Participants of the 10- and 21.1-km Weir Venloop race were enrolled and their urine samples collected before and after the run. Urine dipstick and other conventional tests used to assess kidney function were performed. Presence of ibuprofen, diclofenac, naproxen, and/or paracetamol was assessed by LC-MS/MS. uNGAL was measured with a two-step chemiluminescent immunoassay.

RESULTS

NSAIDs/analgesics were detected in urine of 5 (14.4%) 10-km runners and 13 (28.9%) 21.1-km runners. Only half-marathon participants showed significant increases in uNGAL (pre: 11.7 [7.1-34.3] ng/mL; post: 33.4 [17.4-50.4] ng/mL; p = 0.0038). There was a significant effect of NSAID/analgesic use on uNGAL increase (F2, 76 = 4.210, p = 0.004). Post-hoc tests revealed that uNGAL increased significantly in runners who tested positive for ibuprofen/naproxen compared to runners who did not use any medications (p = 0.045) or those who tested positive for paracetamol (p = 0.033). Running distance had a significant influence on the increase in uNGAL (F1, 53 = 4.741, p < 0.05), specific gravity (F1, 60 = 9.231, p < 0.01), urinary creatinine (F1, 61 = 10.574, p < 0.01), albumin (F1, 59 = 4.888, p < 0.05), and development of hematuria (χ2 (4) = 18.44, p = 0.001).

CONCLUSIONS

Running distance and use of ibuprofen/naproxen were identified as risk factors for uNGAL increase in recreational runners.

Authors+Show Affiliations

Campus Venlo, Maastricht University, Venlo, the Netherlands.VieCuri Medical Center Noord-Limburg, Venlo, the Netherlands.VieCuri Medical Center Noord-Limburg, Venlo, the Netherlands.VieCuri Medical Center Noord-Limburg, Venlo, the Netherlands.Medcaptain Europe BV, the Netherlands.Maastricht University Medical Centre, Maastricht, the Netherlands.VieCuri Medical Center Noord-Limburg, Venlo, the Netherlands.VieCuri Medical Center Noord-Limburg, Venlo, the Netherlands.VieCuri Medical Center Noord-Limburg, Venlo, the Netherlands.Campus Venlo, Maastricht University, Venlo, the Netherlands. Department of Pharmacology and Toxicology, Maastricht University, Maastricht, the Netherlands.VieCuri Medical Center Noord-Limburg, Venlo, the Netherlands. Department of Pharmacology and Toxicology, Maastricht University, Maastricht, the Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32585737

Citation

Semen, Khrystyna O., et al. "Non-steroidal Anti-inflammatory Drugs Increase Urinary Neutrophil Gelatinase-associated Lipocalin in Recreational Runners." Scandinavian Journal of Medicine & Science in Sports, 2020.
Semen KO, van der Doelen RHA, van der Lugt M, et al. Non-steroidal anti-inflammatory drugs increase urinary neutrophil gelatinase-associated lipocalin in recreational runners. Scand J Med Sci Sports. 2020.
Semen, K. O., van der Doelen, R. H. A., van der Lugt, M., van Dam, D., Reimer, J., Stassen, F. R. M., Janssen, L., Janssen, P., Janssen, M. J. W., Bast, A., & le Noble, J. L. M. L. (2020). Non-steroidal anti-inflammatory drugs increase urinary neutrophil gelatinase-associated lipocalin in recreational runners. Scandinavian Journal of Medicine & Science in Sports. https://doi.org/10.1111/sms.13755
Semen KO, et al. Non-steroidal Anti-inflammatory Drugs Increase Urinary Neutrophil Gelatinase-associated Lipocalin in Recreational Runners. Scand J Med Sci Sports. 2020 Jun 25; PubMed PMID: 32585737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-steroidal anti-inflammatory drugs increase urinary neutrophil gelatinase-associated lipocalin in recreational runners. AU - Semen,Khrystyna O, AU - van der Doelen,Rick H A, AU - van der Lugt,Monique, AU - van Dam,Davy, AU - Reimer,Jürgen, AU - Stassen,Frank R M, AU - Janssen,Loes, AU - Janssen,Paddy, AU - Janssen,Marcel J W, AU - Bast,Aalt, AU - le Noble,Jos L M L, Y1 - 2020/06/25/ PY - 2020/6/26/entrez PY - 2020/6/26/pubmed PY - 2020/6/26/medline KW - NSAIDs KW - Renal function KW - half-marathon KW - running KW - urinary neutrophil gelatinase-associated lipocalin (uNGAL) JF - Scandinavian journal of medicine & science in sports JO - Scand J Med Sci Sports N2 - OBJECTIVES: To study the effects of running with/without the use of pain killers on urinary neutrophil gelatinase-associated lipocalin (uNGAL) and other parameters of kidney function in recreational runners. METHODS: Participants of the 10- and 21.1-km Weir Venloop race were enrolled and their urine samples collected before and after the run. Urine dipstick and other conventional tests used to assess kidney function were performed. Presence of ibuprofen, diclofenac, naproxen, and/or paracetamol was assessed by LC-MS/MS. uNGAL was measured with a two-step chemiluminescent immunoassay. RESULTS: NSAIDs/analgesics were detected in urine of 5 (14.4%) 10-km runners and 13 (28.9%) 21.1-km runners. Only half-marathon participants showed significant increases in uNGAL (pre: 11.7 [7.1-34.3] ng/mL; post: 33.4 [17.4-50.4] ng/mL; p = 0.0038). There was a significant effect of NSAID/analgesic use on uNGAL increase (F2, 76 = 4.210, p = 0.004). Post-hoc tests revealed that uNGAL increased significantly in runners who tested positive for ibuprofen/naproxen compared to runners who did not use any medications (p = 0.045) or those who tested positive for paracetamol (p = 0.033). Running distance had a significant influence on the increase in uNGAL (F1, 53 = 4.741, p < 0.05), specific gravity (F1, 60 = 9.231, p < 0.01), urinary creatinine (F1, 61 = 10.574, p < 0.01), albumin (F1, 59 = 4.888, p < 0.05), and development of hematuria (χ2 (4) = 18.44, p = 0.001). CONCLUSIONS: Running distance and use of ibuprofen/naproxen were identified as risk factors for uNGAL increase in recreational runners. SN - 1600-0838 UR - https://www.unboundmedicine.com/medline/citation/32585737/Non-steroidal_anti-inflammatory_drugs_increase_urinary_neutrophil_gelatinase-associated_lipocalin_in_recreational_runners L2 - https://doi.org/10.1111/sms.13755 DB - PRIME DP - Unbound Medicine ER -
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