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Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation.
J Physiol Sci. 2020 Jun 25; 70(1):32.JP

Abstract

Primary acute sympathetic activation (PASA) can increase arterial pressure (AP). Under this situation, the kidneys may receive mutually opposing influences from sympathetic activation: a direct anti-diuretic effect via the renal innervation and pressure diuresis. We examined whether PASA would reduce urine output regardless of the AP elevation. We also examined the impact of renal denervation (RDN) on urine output during PASA. The experiment was performed on rats 3 to 9 days after unilateral RDN (n = 10). Under anesthesia, systemic sympathetic nerve activity (SNA) was varied over a wide range via the carotid sinus baroreflex. The slope of urine flow versus SNA was positive (0.252 ± 0.052 μL·min-1·kg-1· %-1) on the intact side, and it was greater on the denervated side (0.331 ± 0.069 μL·min-1·kg-1· %-1, P < 0.05). In conclusion, urine output change was an effect of elevated AP during PASA. Nevertheless, RDN was able to augment pressure diuresis during PASA.

Authors+Show Affiliations

Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan. torukawa@ncvc.go.jp.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.Corporate R&D Center, Terumo Corporation, Kanagawa, 259-0151, Japan.Corporate R&D Center, Terumo Corporation, Kanagawa, 259-0151, Japan.Corporate R&D Center, Terumo Corporation, Kanagawa, 259-0151, Japan.Corporate R&D Center, Terumo Corporation, Kanagawa, 259-0151, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32586263

Citation

Kawada, Toru, et al. "Open-loop Analysis On Sympathetically Mediated Arterial Pressure and Urine Output Responses in Rats: Effect of Renal Denervation." The Journal of Physiological Sciences : JPS, vol. 70, no. 1, 2020, p. 32.
Kawada T, Hayama Y, Nishikawa T, et al. Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation. J Physiol Sci. 2020;70(1):32.
Kawada, T., Hayama, Y., Nishikawa, T., Suehara, S., Sawada, S., Tanaka, T., Uenohara, M., & Sugimachi, M. (2020). Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation. The Journal of Physiological Sciences : JPS, 70(1), 32. https://doi.org/10.1186/s12576-020-00759-w
Kawada T, et al. Open-loop Analysis On Sympathetically Mediated Arterial Pressure and Urine Output Responses in Rats: Effect of Renal Denervation. J Physiol Sci. 2020 Jun 25;70(1):32. PubMed PMID: 32586263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation. AU - Kawada,Toru, AU - Hayama,Yohsuke, AU - Nishikawa,Takuya, AU - Suehara,Satoru, AU - Sawada,Satoshi, AU - Tanaka,Tetsuo, AU - Uenohara,Minako, AU - Sugimachi,Masaru, Y1 - 2020/06/25/ PY - 2020/03/18/received PY - 2020/06/01/accepted PY - 2020/6/27/entrez KW - Arterial pressure KW - Equilibrium diagram KW - Open-loop analysis KW - Pressure diuresis KW - Sympathetic nerve activity SP - 32 EP - 32 JF - The journal of physiological sciences : JPS JO - J Physiol Sci VL - 70 IS - 1 N2 - Primary acute sympathetic activation (PASA) can increase arterial pressure (AP). Under this situation, the kidneys may receive mutually opposing influences from sympathetic activation: a direct anti-diuretic effect via the renal innervation and pressure diuresis. We examined whether PASA would reduce urine output regardless of the AP elevation. We also examined the impact of renal denervation (RDN) on urine output during PASA. The experiment was performed on rats 3 to 9 days after unilateral RDN (n = 10). Under anesthesia, systemic sympathetic nerve activity (SNA) was varied over a wide range via the carotid sinus baroreflex. The slope of urine flow versus SNA was positive (0.252 ± 0.052 μL·min-1·kg-1· %-1) on the intact side, and it was greater on the denervated side (0.331 ± 0.069 μL·min-1·kg-1· %-1, P < 0.05). In conclusion, urine output change was an effect of elevated AP during PASA. Nevertheless, RDN was able to augment pressure diuresis during PASA. SN - 1880-6562 UR - https://www.unboundmedicine.com/medline/citation/32586263/Open-loop_analysis_on_sympathetically_mediated_arterial_pressure_and_urine_output_responses_in_rats:_effect_of_renal_denervation L2 - https://jps.biomedcentral.com/articles/10.1186/s12576-020-00759-w DB - PRIME DP - Unbound Medicine ER -
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