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Evaluation of organ function in patients with severe COVID-19 infections.
Med Clin (Barc). 2020 09 11; 155(5):191-196.MC

Abstract

OBJECTIVE

The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis.

MATERIAL AND METHODS

A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a survival group (n=73) and a non-survival group (n=29) according to their prognosis. The age, sex, underlying diseases, clinical laboratory data within 48h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. The organ functions of these severe COVID-19 patients were assessed by comparing the differences between the two groups.

RESULTS

AST, BUN, CR, CK-MB, LDH, and CK in the non-survival group were higher than those in the survival group, and the differences were statistically significant (P<0.05). D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than the values observed in the survival group, and the differences were statistically significant (P<0.05). PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH predicted the area under the ROC curve (AUC) of the COVID19 endpoint events and were 0.721, 0.854, 0.867, 0.757, 0.699, 0.679, 0.715, 0.811, 0.935, and 0.802, respectively.

CONCLUSION

The results showed that there were different degrees of damage to the liver, kidneys, blood coagulation, and heart function in the non-survival group. In addition, PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH had value in evaluating disease prognosis.

Authors+Show Affiliations

Department of Emergency, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, PR China.Department of Emergency, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, PR China.Department of Critical Care Medicine, Huangshi Hospital of TCM(Infectious Disease Hospital), 12 Guangchang Road, Huangshi 435000, PR China, 12 Guangchang Road, Huangshi 435000, PR China.Department of Pediatric Intensive Care Unit, E Dong Medical Group Huangshi Central Hospital, 141 Tianjin Road, Huangshi 435000, PR China.Department of Emergency, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, PR China.Department of Emergency, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, PR China. Electronic address: lizhuo2004@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng spa

PubMed ID

32586669

Citation

Zhu, Yingjie, et al. "Evaluation of Organ Function in Patients With Severe COVID-19 Infections." Medicina Clinica, vol. 155, no. 5, 2020, pp. 191-196.
Zhu Y, Du Z, Zhu Y, et al. Evaluation of organ function in patients with severe COVID-19 infections. Med Clin (Barc). 2020;155(5):191-196.
Zhu, Y., Du, Z., Zhu, Y., Li, W., Miao, H., & Li, Z. (2020). Evaluation of organ function in patients with severe COVID-19 infections. Medicina Clinica, 155(5), 191-196. https://doi.org/10.1016/j.medcli.2020.05.012
Zhu Y, et al. Evaluation of Organ Function in Patients With Severe COVID-19 Infections. Med Clin (Barc). 2020 09 11;155(5):191-196. PubMed PMID: 32586669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of organ function in patients with severe COVID-19 infections. AU - Zhu,Yingjie, AU - Du,Ziqiang, AU - Zhu,Yanfang, AU - Li,Wenfeng, AU - Miao,Hongjun, AU - Li,Zhuo, Y1 - 2020/06/04/ PY - 2020/04/09/received PY - 2020/05/18/revised PY - 2020/05/20/accepted PY - 2020/6/27/pubmed PY - 2020/9/22/medline PY - 2020/6/27/entrez KW - COVID-19 KW - Función del órgano KW - Neumonía KW - Organ function KW - Pneumonia KW - Prognosis KW - Pronóstico SP - 191 EP - 196 JF - Medicina clinica JO - Med Clin (Barc) VL - 155 IS - 5 N2 - OBJECTIVE: The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. MATERIAL AND METHODS: A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a survival group (n=73) and a non-survival group (n=29) according to their prognosis. The age, sex, underlying diseases, clinical laboratory data within 48h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. The organ functions of these severe COVID-19 patients were assessed by comparing the differences between the two groups. RESULTS: AST, BUN, CR, CK-MB, LDH, and CK in the non-survival group were higher than those in the survival group, and the differences were statistically significant (P<0.05). D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than the values observed in the survival group, and the differences were statistically significant (P<0.05). PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH predicted the area under the ROC curve (AUC) of the COVID19 endpoint events and were 0.721, 0.854, 0.867, 0.757, 0.699, 0.679, 0.715, 0.811, 0.935, and 0.802, respectively. CONCLUSION: The results showed that there were different degrees of damage to the liver, kidneys, blood coagulation, and heart function in the non-survival group. In addition, PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH had value in evaluating disease prognosis. SN - 1578-8989 UR - https://www.unboundmedicine.com/medline/citation/32586669/Evaluation_of_organ_function_in_patients_with_severe_COVID_19_infections_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0025-7753(20)30339-0 DB - PRIME DP - Unbound Medicine ER -