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Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia.
Sci Rep. 2020 Jun 25; 10(1):10312.SR

Abstract

Acupuncture has been used to treat a variety of illness and involves the insertion and manipulation of needles into specific points on the body (termed "acupoints"). It has been suggested that acupoints are not merely discrete, static points, but can be dynamically changed according to the pathological state of internal organs. We investigated in a rat model of mustard oil (MO)-induced visceral hyperalgesia whether the number and size of acupoints were modified according to the severity of the colonic pain, and whether the changes were associated with enhanced activity of the spinal dorsal horn. In MO-treated rats, acupoints showing neurogenic inflammation (termed "neurogenic spots" or Neuro-Sps) were found both bilaterally and unilaterally on the leg. The number and size of these acupoints increased along with increasing doses of MO. Electroacupuncture of the acupoints generated analgesic effects on MO-induced visceral hypersensitivity. The MO-treated rats showed an increase in c-Fos expression in spinal dorsal horn neurons and displayed increased evoked activity and a prolonged after-discharge in spinal wide dynamic response (WDR) neurons in response to colorectal distension. Increased number and size of neurogenic inflammatory acupoints following MO treatment were reduced by inhibiting AMPA and NMDA receptors in the spinal cord. Our findings suggest that acupoints demonstrate increased number and size along with severity of visceral pain, which may be associated with enhanced neuronal responses in spinal dorsal horn neurons.

Authors+Show Affiliations

Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, South Korea.Department of Psychopharmacology, Qiqihar Medical University, Qiqihar, 161006, China.Department of Psychology and Neuroscience, Brigham Young University, Provo, Utah, 84602, USA.Department of Psychology and Neuroscience, Brigham Young University, Provo, Utah, 84602, USA.Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea.Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, South Korea. hykim@dhu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32587303

Citation

Fan, Yu, et al. "Enhanced Spinal Neuronal Responses as a Mechanism for Increased Number and Size of Active Acupoints in Visceral Hyperalgesia." Scientific Reports, vol. 10, no. 1, 2020, p. 10312.
Fan Y, Ryu Y, Zhao R, et al. Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia. Sci Rep. 2020;10(1):10312.
Fan, Y., Ryu, Y., Zhao, R., Bills, K. B., Steffensen, S. C., Yang, C. H., & Kim, H. Y. (2020). Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia. Scientific Reports, 10(1), 10312. https://doi.org/10.1038/s41598-020-67242-9
Fan Y, et al. Enhanced Spinal Neuronal Responses as a Mechanism for Increased Number and Size of Active Acupoints in Visceral Hyperalgesia. Sci Rep. 2020 Jun 25;10(1):10312. PubMed PMID: 32587303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia. AU - Fan,Yu, AU - Ryu,Yeonhee, AU - Zhao,Rongjie, AU - Bills,Kyle B, AU - Steffensen,Scott C, AU - Yang,Chae Ha, AU - Kim,Hee Young, Y1 - 2020/06/25/ PY - 2020/02/05/received PY - 2020/06/04/accepted PY - 2020/6/27/entrez PY - 2020/6/27/pubmed PY - 2020/6/27/medline SP - 10312 EP - 10312 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - Acupuncture has been used to treat a variety of illness and involves the insertion and manipulation of needles into specific points on the body (termed "acupoints"). It has been suggested that acupoints are not merely discrete, static points, but can be dynamically changed according to the pathological state of internal organs. We investigated in a rat model of mustard oil (MO)-induced visceral hyperalgesia whether the number and size of acupoints were modified according to the severity of the colonic pain, and whether the changes were associated with enhanced activity of the spinal dorsal horn. In MO-treated rats, acupoints showing neurogenic inflammation (termed "neurogenic spots" or Neuro-Sps) were found both bilaterally and unilaterally on the leg. The number and size of these acupoints increased along with increasing doses of MO. Electroacupuncture of the acupoints generated analgesic effects on MO-induced visceral hypersensitivity. The MO-treated rats showed an increase in c-Fos expression in spinal dorsal horn neurons and displayed increased evoked activity and a prolonged after-discharge in spinal wide dynamic response (WDR) neurons in response to colorectal distension. Increased number and size of neurogenic inflammatory acupoints following MO treatment were reduced by inhibiting AMPA and NMDA receptors in the spinal cord. Our findings suggest that acupoints demonstrate increased number and size along with severity of visceral pain, which may be associated with enhanced neuronal responses in spinal dorsal horn neurons. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/32587303/Enhanced_spinal_neuronal_responses_as_a_mechanism_for_increased_number_and_size_of_active_acupoints_in_visceral_hyperalgesia L2 - http://dx.doi.org/10.1038/s41598-020-67242-9 DB - PRIME DP - Unbound Medicine ER -
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