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Differential Trends in Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Infections in Four Health Care Facilities in a Single Metropolitan Area: A Retrospective Analysis.
Microb Drug Resist. 2020 Jun 23 [Online ahead of print]MD

Abstract

Background:

Prevalence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) is increasing worldwide, but greatly varies geographically. We compared the prevalence of ESBL-E. coli infections at four distinct health care facilities in San Francisco, California.

Methods:

Antimicrobial susceptibility reports were obtained for E. coli isolates from (1) a county hospital, (2) a public skilled nursing facility, (3) a university hospital, and (4) a Veterans Affairs (VA) Medical Center. We compared change in frequency of ESBL-E. coli and antimicrobial resistance to trimethoprim-sulfamethoxazole between 2012 and 2018.

Results:

From 2012 to 2018, frequency of ESBL-E. coli increased in urine and nonurine isolates from the county hospital (urine: 1.1% per year, 95% confidence interval [CI]: 0.5-1.6, p < 0.01; nonurine: 1.9% per year, 95% CI: 0.9-2.9, p < 0.01) and in urine isolates from the VA hospital (0.9% per year, 95% CI: 0.3-1.4, p < 0.01). The frequency of trimethoprim-sulfamethoxazole resistance fluctuated in all facilities.

Conclusions:

At the skilled nursing facility, the prevalence of ESBL-E. coli was highest, but remained stable over time, while the prevalence of ESBL-E. coli increased among urine and nonurine isolates at the county hospital and urine isolates at the VA hospital. The temporal trend of ESBL-E. coli infections, even within one city, varied by health care facility.

Authors+Show Affiliations

Department of Family and Community Medicine and University of California, San Francisco, San Francisco, California, USA.Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32589493

Citation

Raphael, Eva, and Henry F. Chambers. "Differential Trends in Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Infections in Four Health Care Facilities in a Single Metropolitan Area: a Retrospective Analysis." Microbial Drug Resistance (Larchmont, N.Y.), 2020.
Raphael E, Chambers HF. Differential Trends in Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Infections in Four Health Care Facilities in a Single Metropolitan Area: A Retrospective Analysis. Microb Drug Resist. 2020.
Raphael, E., & Chambers, H. F. (2020). Differential Trends in Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Infections in Four Health Care Facilities in a Single Metropolitan Area: A Retrospective Analysis. Microbial Drug Resistance (Larchmont, N.Y.). https://doi.org/10.1089/mdr.2020.0058
Raphael E, Chambers HF. Differential Trends in Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Infections in Four Health Care Facilities in a Single Metropolitan Area: a Retrospective Analysis. Microb Drug Resist. 2020 Jun 23; PubMed PMID: 32589493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential Trends in Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Infections in Four Health Care Facilities in a Single Metropolitan Area: A Retrospective Analysis. AU - Raphael,Eva, AU - Chambers,Henry F, Y1 - 2020/06/23/ PY - 2020/6/27/entrez PY - 2020/6/27/pubmed PY - 2020/6/27/medline KW - ESBL-E. coli KW - cephalosporin resistance KW - extended-spectrum beta-lactamase KW - urinary tract infections JF - Microbial drug resistance (Larchmont, N.Y.) JO - Microb. Drug Resist. N2 - Background: Prevalence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) is increasing worldwide, but greatly varies geographically. We compared the prevalence of ESBL-E. coli infections at four distinct health care facilities in San Francisco, California. Methods: Antimicrobial susceptibility reports were obtained for E. coli isolates from (1) a county hospital, (2) a public skilled nursing facility, (3) a university hospital, and (4) a Veterans Affairs (VA) Medical Center. We compared change in frequency of ESBL-E. coli and antimicrobial resistance to trimethoprim-sulfamethoxazole between 2012 and 2018. Results: From 2012 to 2018, frequency of ESBL-E. coli increased in urine and nonurine isolates from the county hospital (urine: 1.1% per year, 95% confidence interval [CI]: 0.5-1.6, p < 0.01; nonurine: 1.9% per year, 95% CI: 0.9-2.9, p < 0.01) and in urine isolates from the VA hospital (0.9% per year, 95% CI: 0.3-1.4, p < 0.01). The frequency of trimethoprim-sulfamethoxazole resistance fluctuated in all facilities. Conclusions: At the skilled nursing facility, the prevalence of ESBL-E. coli was highest, but remained stable over time, while the prevalence of ESBL-E. coli increased among urine and nonurine isolates at the county hospital and urine isolates at the VA hospital. The temporal trend of ESBL-E. coli infections, even within one city, varied by health care facility. SN - 1931-8448 UR - https://www.unboundmedicine.com/medline/citation/32589493/Differential_Trends_in_Extended-Spectrum_Beta-Lactamase-Producing_Escherichia_coli_Infections_in_Four_Health_Care_Facilities_in_a_Single_Metropolitan_Area:_A_Retrospective_Analysis L2 - https://www.liebertpub.com/doi/10.1089/mdr.2020.0058?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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