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Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19.
Microbes Infect. 2020 Oct; 22(9):405-406.MI

Abstract

Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.

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Authors+Show Affiliations

Coish JM
Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, L2S 3A1, Canada. Electronic address: jc11yv@brocku.ca.
MacNeil AJ
Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, L2S 3A1, Canada. Electronic address: amacneil@brocku.ca.

MeSH

Antibodies, NeutralizingAntibodies, ViralAntibody-Dependent EnhancementBetacoronavirusCOVID-19COVID-19 VaccinesCoronavirus InfectionsHumansPandemicsPatient SafetyPneumonia, ViralSARS-CoV-2Severity of Illness IndexVaccinationVaccination RefusalViral VaccinesVirus Replication

Pub Type(s)

Editorial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32590062

Citation

Coish, Jeremia M., and Adam J. MacNeil. "Out of the Frying Pan and Into the Fire? Due Diligence Warranted for ADE in COVID-19." Microbes and Infection, vol. 22, no. 9, 2020, pp. 405-406.
Coish JM, MacNeil AJ. Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19. Microbes Infect. 2020;22(9):405-406.
Coish, J. M., & MacNeil, A. J. (2020). Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19. Microbes and Infection, 22(9), 405-406. https://doi.org/10.1016/j.micinf.2020.06.006
Coish JM, MacNeil AJ. Out of the Frying Pan and Into the Fire? Due Diligence Warranted for ADE in COVID-19. Microbes Infect. 2020;22(9):405-406. PubMed PMID: 32590062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19. AU - Coish,Jeremia M, AU - MacNeil,Adam J, Y1 - 2020/06/24/ PY - 2020/6/8/received PY - 2020/6/18/revised PY - 2020/6/18/accepted PY - 2020/6/27/pubmed PY - 2020/11/20/medline PY - 2020/6/27/entrez SP - 405 EP - 406 JF - Microbes and infection JO - Microbes Infect VL - 22 IS - 9 N2 - Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust. SN - 1769-714X UR - https://www.unboundmedicine.com/medline/citation/32590062/Out_of_the_frying_pan_and_into_the_fire_Due_diligence_warranted_for_ADE_in_COVID_19_ DB - PRIME DP - Unbound Medicine ER -