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Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient.
Clin Neuropharmacol. 2020 Jul/Aug; 43(4):125-126.CN

Abstract

BACKGROUND

Cataplexy is a clinical entity that is characterized by transient muscle tone loss that mostly occurring as a part of narcolepsy. On the other hand, isolated cataplexy (IC) (hereditary cataplexy) is defined as loss of muscle tone that is not accompanied by narcolepsy. Emotional reactions may trigger IC episodes. Additionally, human leukocyte antigen (HLA) DQB1 alleles were shown to be related to IC. Various antidepressants are useful in the treatment of IC; however, there is limited knowledge on the use of antipsychotics in the treatment of IC.

CASE REPORT

A 16-year-old adolescent girl was consulted child and adolescent psychiatry outpatient clinic with complaint of sudden episodes of loss of muscle tone. Her HLA typing showed HLA DQB1*03 haplotype. She was diagnosed with IC and was prescribed aripiprazole 2.5 mg/d and her IC symptoms disappeared and never recurred over 6 months of follow-up.

CONCLUSIONS

In this case report, we present an adolescent girl with IC that is successfully treated with aripiprazole, an antipsychotic. This case report suggests that aripiprazole may be safely used in some adolescents who diagnosed with IC.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Necmettin Erbakan University Meram School of Medicine.Department of Child and Adolescent Psychiatry, Ali Kemal Belviranlı Maternity and Children Hospital, Konya, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32590615

Citation

Uzun, Necati, and Mehmet Akif Akıncı. "Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient." Clinical Neuropharmacology, vol. 43, no. 4, 2020, pp. 125-126.
Uzun N, Akıncı MA. Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient. Clin Neuropharmacol. 2020;43(4):125-126.
Uzun, N., & Akıncı, M. A. (2020). Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient. Clinical Neuropharmacology, 43(4), 125-126. https://doi.org/10.1097/WNF.0000000000000398
Uzun N, Akıncı MA. Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient. Clin Neuropharmacol. 2020 Jul/Aug;43(4):125-126. PubMed PMID: 32590615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient. AU - Uzun,Necati, AU - Akıncı,Mehmet Akif, PY - 2020/6/27/pubmed PY - 2020/6/27/medline PY - 2020/6/27/entrez SP - 125 EP - 126 JF - Clinical neuropharmacology JO - Clin Neuropharmacol VL - 43 IS - 4 N2 - BACKGROUND: Cataplexy is a clinical entity that is characterized by transient muscle tone loss that mostly occurring as a part of narcolepsy. On the other hand, isolated cataplexy (IC) (hereditary cataplexy) is defined as loss of muscle tone that is not accompanied by narcolepsy. Emotional reactions may trigger IC episodes. Additionally, human leukocyte antigen (HLA) DQB1 alleles were shown to be related to IC. Various antidepressants are useful in the treatment of IC; however, there is limited knowledge on the use of antipsychotics in the treatment of IC. CASE REPORT: A 16-year-old adolescent girl was consulted child and adolescent psychiatry outpatient clinic with complaint of sudden episodes of loss of muscle tone. Her HLA typing showed HLA DQB1*03 haplotype. She was diagnosed with IC and was prescribed aripiprazole 2.5 mg/d and her IC symptoms disappeared and never recurred over 6 months of follow-up. CONCLUSIONS: In this case report, we present an adolescent girl with IC that is successfully treated with aripiprazole, an antipsychotic. This case report suggests that aripiprazole may be safely used in some adolescents who diagnosed with IC. SN - 1537-162X UR - https://www.unboundmedicine.com/medline/citation/32590615/Treatment_of_Isolated_Cataplexy_With_Low-dose_Aripiprazole_in_an_Adolescent_Patient L2 - https://doi.org/10.1097/WNF.0000000000000398 DB - PRIME DP - Unbound Medicine ER -
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