Tags

Type your tag names separated by a space and hit enter

Chest CT of COVID-19 in patients with a negative first RT-PCR test: Comparison with patients with a positive first RT-PCR test.
Medicine (Baltimore). 2020 Jun 26; 99(26):e20837.M

Abstract

To compare clinical and imaging features between patients with an initial negative reverse-transcription-polymerase chain-reaction (RT-PCR) test and patients with an initial positive RT-PCR test. CT follow-up analysis in the negative RT-PCR group is also described.Thirty-three patients with SARS-CoV-2 infection confirmed by RT-PCR, with 216 lesions upon CT, were included. Demographic information and chest CT imaging features were collected.The average age in the whole study group was 46.9 ± 11.1 years, with 18 males and 15 females. Patients in the positive RT-PCR test group were more likely to have a fever than patients in the negative RT-PCR test group (85.7% vs 50%, P < .05). Lesions in the positive group were more likely to be located in the peripheral area than lesions in the negative group (83.6% vs 68.2%, P < .05). Regarding the appearance of 216 lesions, ground-glass opacities (GGOs) with consolidation (43.2%) was the most common appearance in the negative group, followed by pure GGOs (31.8%), while in the positive group, pure GGOs (32%) and GGOs with interlobular septal thickening (32.8%) were both most frequent, and the difference between them was evident (P < .05). For the follow-up analysis, the largest short-axis of a lesion was smaller upon follow-up (median size 13.6 mm vs 14 mm), albeit by a smaller margin. Pure GGOs decreased in frequency, from 31.3% to 21.3%, while consolidation increased in frequency, from 7.5% to 12.5%.The manifestations of COVID-19 in patients with a first negative RT-PCR test and patients with a positive first RT-PCR test are different to some extent. The consolidation component may increase after follow-up.

Authors+Show Affiliations

Department of Radiology.Department of Radiology.Department of Radiology.Department of Radiology.Department of Radiology.Department of Radiology.Department of Radiology.Department of Science and Education, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University.Department of Radiology, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital). Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China.

Pub Type(s)

Comparative Study
Journal Article
Observational Study

Language

eng

PubMed ID

32590775

Citation

Chen, Zu-Hua, et al. "Chest CT of COVID-19 in Patients With a Negative First RT-PCR Test: Comparison With Patients With a Positive First RT-PCR Test." Medicine, vol. 99, no. 26, 2020, pp. e20837.
Chen ZH, Li YJ, Wang XJ, et al. Chest CT of COVID-19 in patients with a negative first RT-PCR test: Comparison with patients with a positive first RT-PCR test. Medicine (Baltimore). 2020;99(26):e20837.
Chen, Z. H., Li, Y. J., Wang, X. J., Ye, Y. F., Wu, B. L., Zhang, Y., Xuan, W. L., Bao, J. F., & Deng, X. Y. (2020). Chest CT of COVID-19 in patients with a negative first RT-PCR test: Comparison with patients with a positive first RT-PCR test. Medicine, 99(26), e20837. https://doi.org/10.1097/MD.0000000000020837
Chen ZH, et al. Chest CT of COVID-19 in Patients With a Negative First RT-PCR Test: Comparison With Patients With a Positive First RT-PCR Test. Medicine (Baltimore). 2020 Jun 26;99(26):e20837. PubMed PMID: 32590775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chest CT of COVID-19 in patients with a negative first RT-PCR test: Comparison with patients with a positive first RT-PCR test. AU - Chen,Zu-Hua, AU - Li,Yun-Jiang, AU - Wang,Xiu-Juan, AU - Ye,Yun-Feng, AU - Wu,Bao-Liang, AU - Zhang,Yan, AU - Xuan,Wei-Ling, AU - Bao,Jian-Feng, AU - Deng,Xue-Ying, PY - 2020/6/27/entrez PY - 2020/6/27/pubmed PY - 2020/7/3/medline SP - e20837 EP - e20837 JF - Medicine JO - Medicine (Baltimore) VL - 99 IS - 26 N2 - To compare clinical and imaging features between patients with an initial negative reverse-transcription-polymerase chain-reaction (RT-PCR) test and patients with an initial positive RT-PCR test. CT follow-up analysis in the negative RT-PCR group is also described.Thirty-three patients with SARS-CoV-2 infection confirmed by RT-PCR, with 216 lesions upon CT, were included. Demographic information and chest CT imaging features were collected.The average age in the whole study group was 46.9 ± 11.1 years, with 18 males and 15 females. Patients in the positive RT-PCR test group were more likely to have a fever than patients in the negative RT-PCR test group (85.7% vs 50%, P < .05). Lesions in the positive group were more likely to be located in the peripheral area than lesions in the negative group (83.6% vs 68.2%, P < .05). Regarding the appearance of 216 lesions, ground-glass opacities (GGOs) with consolidation (43.2%) was the most common appearance in the negative group, followed by pure GGOs (31.8%), while in the positive group, pure GGOs (32%) and GGOs with interlobular septal thickening (32.8%) were both most frequent, and the difference between them was evident (P < .05). For the follow-up analysis, the largest short-axis of a lesion was smaller upon follow-up (median size 13.6 mm vs 14 mm), albeit by a smaller margin. Pure GGOs decreased in frequency, from 31.3% to 21.3%, while consolidation increased in frequency, from 7.5% to 12.5%.The manifestations of COVID-19 in patients with a first negative RT-PCR test and patients with a positive first RT-PCR test are different to some extent. The consolidation component may increase after follow-up. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/32590775/Chest_CT_of_COVID_19_in_patients_with_a_negative_first_RT_PCR_test:_Comparison_with_patients_with_a_positive_first_RT_PCR_test_ L2 - https://doi.org/10.1097/MD.0000000000020837 DB - PRIME DP - Unbound Medicine ER -