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Relationship Between ACE2 and Other Components of the Renin-Angiotensin System.
Curr Hypertens Rep. 2020 06 26; 22(7):44.CH

Abstract

PURPOSE OF THE REVIEW

Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection.

RECENT FINDINGS

ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.

Authors+Show Affiliations

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jco@pennmedicine.upenn.edu. Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jco@pennmedicine.upenn.edu.Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.Division of Health System Innovation and Research, Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.Section of Nephrology, Department of Pediatrics, Wake Forest School of Medicine and Brenner Children's Hospital, Winston Salem, USA. Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, USA. Department of Surgery-Hypertension and Vascular Research, Wake Forest School of Medicine, Winston Salem, NC, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32591908

Citation

Cohen, Jordana B., et al. "Relationship Between ACE2 and Other Components of the Renin-Angiotensin System." Current Hypertension Reports, vol. 22, no. 7, 2020, p. 44.
Cohen JB, Hanff TC, Bress AP, et al. Relationship Between ACE2 and Other Components of the Renin-Angiotensin System. Curr Hypertens Rep. 2020;22(7):44.
Cohen, J. B., Hanff, T. C., Bress, A. P., & South, A. M. (2020). Relationship Between ACE2 and Other Components of the Renin-Angiotensin System. Current Hypertension Reports, 22(7), 44. https://doi.org/10.1007/s11906-020-01048-y
Cohen JB, et al. Relationship Between ACE2 and Other Components of the Renin-Angiotensin System. Curr Hypertens Rep. 2020 06 26;22(7):44. PubMed PMID: 32591908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship Between ACE2 and Other Components of the Renin-Angiotensin System. AU - Cohen,Jordana B, AU - Hanff,Thomas C, AU - Bress,Adam P, AU - South,Andrew M, Y1 - 2020/06/26/ PY - 2020/6/28/entrez PY - 2020/6/28/pubmed PY - 2020/7/9/medline KW - Angiotensin receptor blockers KW - Angiotensin-converting enzyme KW - Angiotensin-converting enzyme inhibitors KW - COVID-19 KW - Cardiovascular disease KW - Chronic kidney disease KW - Coronavirus infections KW - Hypertension KW - Renin-angiotensin system SP - 44 EP - 44 JF - Current hypertension reports JO - Curr. Hypertens. Rep. VL - 22 IS - 7 N2 - PURPOSE OF THE REVIEW: Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. RECENT FINDINGS: ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes. SN - 1534-3111 UR - https://www.unboundmedicine.com/medline/citation/32591908/Relationship_Between_ACE2_and_Other_Components_of_the_Renin_Angiotensin_System_ L2 - https://dx.doi.org/10.1007/s11906-020-01048-y DB - PRIME DP - Unbound Medicine ER -