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Sentinel Node Biopsy in Early Breast Cancer Patients with Palpable Axillary Node.
Asian Pac J Cancer Prev. 2020 Jun 01; 21(6):1631-1636.AP

Abstract

BACKGROUND

Sentinel lymph node biopsy is a reliable method for evaluation of the axillary lymph node status in early stage breast cancer patients with non-palpable lymph nodes. The present study evaluated the status of sentinel and non-sentinel lymph nodes in T1T2 patients with palpable axillary lymph nodes.

MATERIALS AND METHODS

One hundred and two women with early breast cancer were investigated in this study. Patients were selected for axillary sentinel lymph node biopsy and then surgery .Then the rates of false negative and true positive, and diagnostic accuracy of sentinel lymph nodes biopsy were evaluated. In addition, the hormone receptors status of the tumor was determined through IHC and data was analyzed in SPSS21.

RESULTS

In this study, the mean age of the patients was 49 years, 85% had invasive ductal carcinoma in their pathology reports, 77% were ER/PR positive, 30% HER2 positive and 9.8% triple negative and 69% had KI67<14%. In frozen pathology, 15.7 and 84.3% were sentinel positive and negative, respectively, and in the final pathology, 41 and 58.8% were sentinel positive and negative, respectively. This difference arises from the false negative rate of the frozen pathology, which was about 31.3%. The sensitivity, specificity, and diagnostic accuracy of the frozen section were 24, 90 and 43%, respectively. Lymphovascular invasion is an important effective factor in the involvement of sentinel and non-sentinel lymph nodes. Statistical analysis showed that the probability of sentinel and non-sentinel lymph nodes involvement was higher in receptor positive patients and those with KI67>14% (p<0.002) whereas the rate of involvement was lower in triple negative patients.

CONCLUSION

Sentinel node biopsy can be used in a significant percentage of breast cancer patients with palpable and reactive axillary lymph nodes.

Authors+Show Affiliations

Department of Surgery, Mazandaran University of Medical Sciences, Sari, Iran.Department of Surgery, Mazandaran University of Medical Sciences, Sari, Iran.Department of Breast Surgery, Iran University of Medical Sciences, Tehran, Iran.Department of Pathology, Mazandaran University of Medical Sciences, Sari, Iran.Department of Surgery, Mazandaran University of Medical Sciences, Sari, Iran.School of Epidmiology, Mazandaran University of Medical Sciences, Sari, Iran.School of Medicine, Student Research Committee of Mazandaran University of Medical, Sari, Iran.School of Medicine, Student Research Committee of Mazandaran University of Medical, Sari, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32592357

Citation

Shojaee, Leyla, et al. "Sentinel Node Biopsy in Early Breast Cancer Patients With Palpable Axillary Node." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 21, no. 6, 2020, pp. 1631-1636.
Shojaee L, Abedinnegad S, Nafisi N, et al. Sentinel Node Biopsy in Early Breast Cancer Patients with Palpable Axillary Node. Asian Pac J Cancer Prev. 2020;21(6):1631-1636.
Shojaee, L., Abedinnegad, S., Nafisi, N., Naghshvar, F., Godazandeh, G., Moradi, S., Shakeri Astani, K., & Godazandeh, Y. (2020). Sentinel Node Biopsy in Early Breast Cancer Patients with Palpable Axillary Node. Asian Pacific Journal of Cancer Prevention : APJCP, 21(6), 1631-1636. https://doi.org/10.31557/APJCP.2020.21.6.1631
Shojaee L, et al. Sentinel Node Biopsy in Early Breast Cancer Patients With Palpable Axillary Node. Asian Pac J Cancer Prev. 2020 Jun 1;21(6):1631-1636. PubMed PMID: 32592357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sentinel Node Biopsy in Early Breast Cancer Patients with Palpable Axillary Node. AU - Shojaee,Leyla, AU - Abedinnegad,Sheida, AU - Nafisi,Nahid, AU - Naghshvar,Farshad, AU - Godazandeh,Gholamali, AU - Moradi,Siavosh, AU - Shakeri Astani,Kiarash, AU - Godazandeh,Yasaman, Y1 - 2020/06/01/ PY - 2019/10/17/received PY - 2020/6/28/entrez PY - 2020/6/28/pubmed PY - 2020/6/28/medline KW - Palpable Lymph Node KW - breast cancer KW - sentinel lymph node biopsy SP - 1631 EP - 1636 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 21 IS - 6 N2 - BACKGROUND: Sentinel lymph node biopsy is a reliable method for evaluation of the axillary lymph node status in early stage breast cancer patients with non-palpable lymph nodes. The present study evaluated the status of sentinel and non-sentinel lymph nodes in T1T2 patients with palpable axillary lymph nodes. MATERIALS AND METHODS: One hundred and two women with early breast cancer were investigated in this study. Patients were selected for axillary sentinel lymph node biopsy and then surgery .Then the rates of false negative and true positive, and diagnostic accuracy of sentinel lymph nodes biopsy were evaluated. In addition, the hormone receptors status of the tumor was determined through IHC and data was analyzed in SPSS21. RESULTS: In this study, the mean age of the patients was 49 years, 85% had invasive ductal carcinoma in their pathology reports, 77% were ER/PR positive, 30% HER2 positive and 9.8% triple negative and 69% had KI67<14%. In frozen pathology, 15.7 and 84.3% were sentinel positive and negative, respectively, and in the final pathology, 41 and 58.8% were sentinel positive and negative, respectively. This difference arises from the false negative rate of the frozen pathology, which was about 31.3%. The sensitivity, specificity, and diagnostic accuracy of the frozen section were 24, 90 and 43%, respectively. Lymphovascular invasion is an important effective factor in the involvement of sentinel and non-sentinel lymph nodes. Statistical analysis showed that the probability of sentinel and non-sentinel lymph nodes involvement was higher in receptor positive patients and those with KI67>14% (p<0.002) whereas the rate of involvement was lower in triple negative patients. CONCLUSION: Sentinel node biopsy can be used in a significant percentage of breast cancer patients with palpable and reactive axillary lymph nodes. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/32592357/Sentinel_Node_Biopsy_in_Early_Breast_Cancer_Patients_with_Palpable_Axillary_Node L2 - http://journal.waocp.org/?sid=Entrez:PubMed&amp;id=pmid:32592357&amp;key=2020.21.6.1631 DB - PRIME DP - Unbound Medicine ER -
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