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Cyanidin-related antidepressant-like efficacy requires PI3K/AKT/FoxG1/FGF-2 pathway modulated enhancement of neuronal differentiation and dendritic maturation.
Phytomedicine. 2020 Jun 20; 76:153269.P

Abstract

BACKGROUND

Cyanidin (CY) is one of the most abundant anthocyanidins found in red-purple diet sources such as grapes, blueberries and purple corns. CY has been proven to exhibit a wide range of biological functions including antioxidant, antiviral, anticarcinogenic and anti-inflammatory properties.

PURPOSE

This study investigated the anti-depressive activity of CY and its related mechanism.

METHODS

In the behavioral tests, CY-related effects on depressive symptoms were evaluated. Then the changes in PI3K/AKT/FOXG1/FGF-2 signaling and adult neurogenesis including doublecortin (DCX+) cell number, dendritic length, secondary and third dendrites number in the hippocampus were investigated by Immunofluorescence and Western blot analyses. PI3K antagonist LY 294,002 was used to verify the unique impact of PI3K/AKT/FoxG1/FGF-2 signaling on CY-related antidepressant efficacy.

RESULTS

CY grossly reversed CUMS-induced behavioral defects, The DCX+ cell number and protein levels increased in CUMS mice receiving CY administration. LY 294,002 successfully blocked CY-induced improvements in depressive behaviors, neurogenesis, and protein levels in CUMS mice.

CONCLUSION

The findings demonstrated that CY was efficacious in alleviating depression-like symptoms, which was dependent on PI3K/AKT/FoxG1/FGF-2 signaling-modulated neurogenesis enhancement.

Authors+Show Affiliations

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China; Hanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, China.Hanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, China.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China.Hanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, China.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China.Hanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, China.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China. Electronic address: qnwyjs@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32593103

Citation

Shan, Xin, et al. "Cyanidin-related Antidepressant-like Efficacy Requires PI3K/AKT/FoxG1/FGF-2 Pathway Modulated Enhancement of Neuronal Differentiation and Dendritic Maturation." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 76, 2020, p. 153269.
Shan X, Chen J, Dai S, et al. Cyanidin-related antidepressant-like efficacy requires PI3K/AKT/FoxG1/FGF-2 pathway modulated enhancement of neuronal differentiation and dendritic maturation. Phytomedicine. 2020;76:153269.
Shan, X., Chen, J., Dai, S., Wang, J., Huang, Z., Lv, Z., Wang, Q., & Wu, Q. (2020). Cyanidin-related antidepressant-like efficacy requires PI3K/AKT/FoxG1/FGF-2 pathway modulated enhancement of neuronal differentiation and dendritic maturation. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 76, 153269. https://doi.org/10.1016/j.phymed.2020.153269
Shan X, et al. Cyanidin-related Antidepressant-like Efficacy Requires PI3K/AKT/FoxG1/FGF-2 Pathway Modulated Enhancement of Neuronal Differentiation and Dendritic Maturation. Phytomedicine. 2020 Jun 20;76:153269. PubMed PMID: 32593103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyanidin-related antidepressant-like efficacy requires PI3K/AKT/FoxG1/FGF-2 pathway modulated enhancement of neuronal differentiation and dendritic maturation. AU - Shan,Xin, AU - Chen,Jing, AU - Dai,Shilin, AU - Wang,Jie, AU - Huang,Zhiheng, AU - Lv,Zhiyang, AU - Wang,Qian, AU - Wu,Qinan, Y1 - 2020/06/20/ PY - 2020/01/30/received PY - 2020/06/10/revised PY - 2020/06/19/accepted PY - 2020/6/28/pubmed PY - 2020/6/28/medline PY - 2020/6/28/entrez KW - Adult neurogenesis KW - Cyanidin KW - Depression KW - PI3K/AKT/FoxG1/FGF-2 SP - 153269 EP - 153269 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 76 N2 - BACKGROUND: Cyanidin (CY) is one of the most abundant anthocyanidins found in red-purple diet sources such as grapes, blueberries and purple corns. CY has been proven to exhibit a wide range of biological functions including antioxidant, antiviral, anticarcinogenic and anti-inflammatory properties. PURPOSE: This study investigated the anti-depressive activity of CY and its related mechanism. METHODS: In the behavioral tests, CY-related effects on depressive symptoms were evaluated. Then the changes in PI3K/AKT/FOXG1/FGF-2 signaling and adult neurogenesis including doublecortin (DCX+) cell number, dendritic length, secondary and third dendrites number in the hippocampus were investigated by Immunofluorescence and Western blot analyses. PI3K antagonist LY 294,002 was used to verify the unique impact of PI3K/AKT/FoxG1/FGF-2 signaling on CY-related antidepressant efficacy. RESULTS: CY grossly reversed CUMS-induced behavioral defects, The DCX+ cell number and protein levels increased in CUMS mice receiving CY administration. LY 294,002 successfully blocked CY-induced improvements in depressive behaviors, neurogenesis, and protein levels in CUMS mice. CONCLUSION: The findings demonstrated that CY was efficacious in alleviating depression-like symptoms, which was dependent on PI3K/AKT/FoxG1/FGF-2 signaling-modulated neurogenesis enhancement. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/32593103/Cyanidin-related_antidepressant-like_efficacy_requires_PI3K/AKT/FoxG1/FGF-2_pathway_modulated_enhancement_of_neuronal_differentiation_and_dendritic_maturation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(20)30100-8 DB - PRIME DP - Unbound Medicine ER -
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