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Blockade of muscarinic receptors impairs reconsolidation of older fear memory by decreasing cholinergic neurotransmission: A study in rat model of PTSD.
Life Sci. 2020 Jun 25 [Online ahead of print]LS

Abstract

The age and strength of fear memory are two potential parameters that can be influenced by the impairing effects of pharmacological agents on reconsolidation of fear memory. In reconsolidation, stored information is rendered labile again after being reactivated. Pharmacological manipulations at this stage result in an inability to retrieve the fear memories, suggesting that they are erased or persistently inhibited. This fear memory impairment phenomenon can be valuable to treat post-traumatic stress disorders (PTSD). Previously β-adrenergic antagonist propranolol has been repeatedly reported to impair fear memory in the treatment of PTSD. Atropine has also shown to disrupt memory formation. The present study was therefore designed to compare the effects of atropine and propranolol on reconsolidation of older fear memory in rat model of PTSD using Pavlovian fear conditioning apparatus. For this purpose 18 rats were taken and divided into control, atropine and propranolol groups and subjected to Pavlovian fear conditioning trials in order to develop animal model of PTSD. To evaluate the reconsolidation impairment of fear memory by atropine and propranolol, short term and long term memory was tested after reactivation of fear memory in rats. The present findings demonstrate that atropine significantly decreases fear expression. These results suggest that atropine significantly reduces the strength of fear memories and may be effective in the treatment of psychiatric disorders especially in PTSD.

Authors+Show Affiliations

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan.Dr. Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. Electronic address: xehra_batool@yahoo.com.Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan.Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32593712

Citation

Rafiq, Sahar, et al. "Blockade of Muscarinic Receptors Impairs Reconsolidation of Older Fear Memory By Decreasing Cholinergic Neurotransmission: a Study in Rat Model of PTSD." Life Sciences, 2020, p. 118014.
Rafiq S, Batool Z, Liaquat L, et al. Blockade of muscarinic receptors impairs reconsolidation of older fear memory by decreasing cholinergic neurotransmission: A study in rat model of PTSD. Life Sci. 2020.
Rafiq, S., Batool, Z., Liaquat, L., & Haider, S. (2020). Blockade of muscarinic receptors impairs reconsolidation of older fear memory by decreasing cholinergic neurotransmission: A study in rat model of PTSD. Life Sciences, 118014. https://doi.org/10.1016/j.lfs.2020.118014
Rafiq S, et al. Blockade of Muscarinic Receptors Impairs Reconsolidation of Older Fear Memory By Decreasing Cholinergic Neurotransmission: a Study in Rat Model of PTSD. Life Sci. 2020 Jun 25;118014. PubMed PMID: 32593712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blockade of muscarinic receptors impairs reconsolidation of older fear memory by decreasing cholinergic neurotransmission: A study in rat model of PTSD. AU - Rafiq,Sahar, AU - Batool,Zehra, AU - Liaquat,Laraib, AU - Haider,Saida, Y1 - 2020/06/25/ PY - 2020/03/20/received PY - 2020/06/21/revised PY - 2020/06/22/accepted PY - 2020/6/29/entrez KW - Acetylcholine KW - Fear memory KW - PTSD KW - Reconsolidation SP - 118014 EP - 118014 JF - Life sciences JO - Life Sci. N2 - The age and strength of fear memory are two potential parameters that can be influenced by the impairing effects of pharmacological agents on reconsolidation of fear memory. In reconsolidation, stored information is rendered labile again after being reactivated. Pharmacological manipulations at this stage result in an inability to retrieve the fear memories, suggesting that they are erased or persistently inhibited. This fear memory impairment phenomenon can be valuable to treat post-traumatic stress disorders (PTSD). Previously β-adrenergic antagonist propranolol has been repeatedly reported to impair fear memory in the treatment of PTSD. Atropine has also shown to disrupt memory formation. The present study was therefore designed to compare the effects of atropine and propranolol on reconsolidation of older fear memory in rat model of PTSD using Pavlovian fear conditioning apparatus. For this purpose 18 rats were taken and divided into control, atropine and propranolol groups and subjected to Pavlovian fear conditioning trials in order to develop animal model of PTSD. To evaluate the reconsolidation impairment of fear memory by atropine and propranolol, short term and long term memory was tested after reactivation of fear memory in rats. The present findings demonstrate that atropine significantly decreases fear expression. These results suggest that atropine significantly reduces the strength of fear memories and may be effective in the treatment of psychiatric disorders especially in PTSD. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/32593712/Blockade_of_muscarinic_receptors_impairs_reconsolidation_of_older_fear_memory_by_decreasing_cholinergic_neurotransmission:_A_study_in_rat_model_of_PTSD L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(20)30764-5 DB - PRIME DP - Unbound Medicine ER -
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