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Treatment of electrical wrist stimulation reduces chemotherapy-induced neuropathy and ultrasound vocalization via modulation of spinal NR2B phosphorylation.
Brain Res Bull. 2020 Sep; 162:237-244.BR

Abstract

Docetaxel, a chemotherapeutic agent used to treat breast cancer, produces a robust painful neuropathy that is aggravated by mechanical and thermal stimuli. This study was undertaken to investigate the analgesic effects of electrical stimulation on docetaxel-induced neuropathic pain in mice and to identify associated changes in ultrasound vocalizations. Peripheral neuropathy was induced with intraperitoneally injected docetaxel (5 mg/kg) on 3 times every 2 days in male ICR mice. Electrical wrist stimulation was administered and pain behavior signs were evaluated by von Frey filaments and thermal stimulation on the hind paw. Ultrasound vocalizations were measured using ultrasound microphones, after electrical stimulation. After mice developed docetaxel-induced neuropathic pain behavior, an electrical stimulation temporarily attenuated mechanical allodynia and thermal hyperalgesia. In formalin and NMDA test, pain-induced mice showed increases in 10-30 kHz ultrasound vocalizations, but not in 30-50 and 50-80 kHz vocalizations. Treatment with docetaxel selectively increased 10-30 kHz ultrasound vocalizations, whereas electrical stimulation caused a meaningful decrease. Moreover, electrical stimulation suppressed the docetaxel-enhanced phosphorylation of the NMDA receptor NR2B subunit in the spinal dorsal horn. These results of the analgesic effect of electrical stimulation in chemotherapy-induced neuropathy could potentially provide a new method to treat and manage peripheral neuropathy in patients with cancer.

Authors+Show Affiliations

Clinical Medicine Division, KoreaInstitute of Oriental Medicine, Daejeon, 34054, Republic of Korea. Electronic address: sy8974@kiom.re.kr.Clinical Medicine Division, KoreaInstitute of Oriental Medicine, Daejeon, 34054, Republic of Korea. Electronic address: sichosi@kiom.re.kr.Department of Meridian and Acupuncture points, College of Korean medicine, Wonkwang University, Iksan 54538, Republic of Korea. Electronic address: logos319@wku.ac.kr.Clinical Medicine Division, KoreaInstitute of Oriental Medicine, Daejeon, 34054, Republic of Korea. Electronic address: ssy1025@kiom.re.kr.Clinical Medicine Division, KoreaInstitute of Oriental Medicine, Daejeon, 34054, Republic of Korea. Electronic address: ddoongho@kiom.re.kr.Clinical Medicine Division, KoreaInstitute of Oriental Medicine, Daejeon, 34054, Republic of Korea. Electronic address: ipcng@kiom.re.kr.East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University, Daejeon 35234, Republic of Korea. Electronic address: altyhs@daum.net.Department of surgery, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea. Electronic address: leejin123@daum.net.Department of Physiology and Medical Science, Chungnam National University, Daejeon, 35015, Republic of Korea. Electronic address: kim0827@cnu.ac.kr.Clinical Medicine Division, KoreaInstitute of Oriental Medicine, Daejeon, 34054, Republic of Korea. Electronic address: yhryu@kiom.re.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32593737

Citation

Kang, Suk-Yun, et al. "Treatment of Electrical Wrist Stimulation Reduces Chemotherapy-induced Neuropathy and Ultrasound Vocalization Via Modulation of Spinal NR2B Phosphorylation." Brain Research Bulletin, vol. 162, 2020, pp. 237-244.
Kang SY, Bang SK, Kwon OS, et al. Treatment of electrical wrist stimulation reduces chemotherapy-induced neuropathy and ultrasound vocalization via modulation of spinal NR2B phosphorylation. Brain Res Bull. 2020;162:237-244.
Kang, S. Y., Bang, S. K., Kwon, O. S., Seo, S. Y., Choi, K. H., Cho, S. J., Yoo, H. S., Lee, J. S., Kim, H. W., & Ryu, Y. (2020). Treatment of electrical wrist stimulation reduces chemotherapy-induced neuropathy and ultrasound vocalization via modulation of spinal NR2B phosphorylation. Brain Research Bulletin, 162, 237-244. https://doi.org/10.1016/j.brainresbull.2020.06.016
Kang SY, et al. Treatment of Electrical Wrist Stimulation Reduces Chemotherapy-induced Neuropathy and Ultrasound Vocalization Via Modulation of Spinal NR2B Phosphorylation. Brain Res Bull. 2020;162:237-244. PubMed PMID: 32593737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of electrical wrist stimulation reduces chemotherapy-induced neuropathy and ultrasound vocalization via modulation of spinal NR2B phosphorylation. AU - Kang,Suk-Yun, AU - Bang,Se Kyun, AU - Kwon,O Sang, AU - Seo,Su-Yeon, AU - Choi,Kwang-Ho, AU - Cho,Seong Jin, AU - Yoo,Hwa Seung, AU - Lee,Jin Sun, AU - Kim,Hyun-Woo, AU - Ryu,Yeonhee, Y1 - 2020/06/25/ PY - 2020/01/09/received PY - 2020/05/21/revised PY - 2020/06/22/accepted PY - 2020/7/1/pubmed PY - 2020/7/1/medline PY - 2020/6/29/entrez KW - Analgesia KW - Chemotherapy KW - Docetaxel KW - Electrical stimulation KW - Ultrasound SP - 237 EP - 244 JF - Brain research bulletin JO - Brain Res. Bull. VL - 162 N2 - Docetaxel, a chemotherapeutic agent used to treat breast cancer, produces a robust painful neuropathy that is aggravated by mechanical and thermal stimuli. This study was undertaken to investigate the analgesic effects of electrical stimulation on docetaxel-induced neuropathic pain in mice and to identify associated changes in ultrasound vocalizations. Peripheral neuropathy was induced with intraperitoneally injected docetaxel (5 mg/kg) on 3 times every 2 days in male ICR mice. Electrical wrist stimulation was administered and pain behavior signs were evaluated by von Frey filaments and thermal stimulation on the hind paw. Ultrasound vocalizations were measured using ultrasound microphones, after electrical stimulation. After mice developed docetaxel-induced neuropathic pain behavior, an electrical stimulation temporarily attenuated mechanical allodynia and thermal hyperalgesia. In formalin and NMDA test, pain-induced mice showed increases in 10-30 kHz ultrasound vocalizations, but not in 30-50 and 50-80 kHz vocalizations. Treatment with docetaxel selectively increased 10-30 kHz ultrasound vocalizations, whereas electrical stimulation caused a meaningful decrease. Moreover, electrical stimulation suppressed the docetaxel-enhanced phosphorylation of the NMDA receptor NR2B subunit in the spinal dorsal horn. These results of the analgesic effect of electrical stimulation in chemotherapy-induced neuropathy could potentially provide a new method to treat and manage peripheral neuropathy in patients with cancer. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/32593737/Treatment_of_electrical_wrist_stimulation_reduces_chemotherapy-induced_neuropathy_and_ultrasound_vocalization_via_modulation_of_spinal_NR2B_phosphorylation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(20)30541-4 DB - PRIME DP - Unbound Medicine ER -
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