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Muscle type from which satellite cells are derived plays a role in their damage response.
Chin J Physiol. 2020 May-Jun; 63(3):113-121.CJ

Abstract

The aim of this study was to evaluate the response of satellite cells to muscular atrophies which possess different pathological characteristics and which were induced by distinct damages. Right lower limbs of rats were exposed to denervation or disuse and later its tibialis anterior (TA) or soleus (SOL) muscles were analyzed. After confirming their functional impairments indicated by common but distinct pathological and electrophysiological characteristics, the quantitative polymerase chain reaction analysis of Pax7 and Pax3 expressions and the number of Pax7+ve and Pax3+ve cells were analyzed sequentially at day 0, day 7, and day 14. TA muscles of both denervation- and disuse-induced atrophy models showed persisted low level of Pax7 expression from day 7 (0.91 ± 0.23 and 0.31 ± 0.07, P = 0.06, n = 6) through day 14 (1.09 ± 0.15 and 0.4 ± 0.09 [P < 0.05]). On the other hand, significant elevations were observed in Pax3 expression in both atrophy models (2.73 ± 0.46 and 2.75 ± 0.26 [P < 0.05]) at day 7. Similar to TA muscle, resembled pattern of Pax7 and Pax3 expression changes were observed between the SOL muscles of denervation- and disused-atrophy models. These trends were further confirmed by the changes in Pax7+ve and Pax3+ve cell numbers of TA and SOL muscles in both atrophy models. Despite the distinct pathological findings, similar patterns in the changes of Pax3 and Pax7 expressions and the changes of Pax7+ve and Pax3+ve cell numbers were observed between the denervation- and disuse-induced atrophy models and this commonality was admitted among the muscle type. Therefore, we claim that the muscle regeneration orchestrated by satellite cells was governed by the muscle type in which satellite cells reside.

Authors+Show Affiliations

Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.Department of Family Medicine, Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan.Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University; Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32594064

Citation

Lin, Chuang-Yu, et al. "Muscle Type From Which Satellite Cells Are Derived Plays a Role in Their Damage Response." The Chinese Journal of Physiology, vol. 63, no. 3, 2020, pp. 113-121.
Lin CY, Hou CY, Tsai CM, et al. Muscle type from which satellite cells are derived plays a role in their damage response. Chin J Physiol. 2020;63(3):113-121.
Lin, C. Y., Hou, C. Y., Tsai, C. M., & Chang, H. (2020). Muscle type from which satellite cells are derived plays a role in their damage response. The Chinese Journal of Physiology, 63(3), 113-121. https://doi.org/10.4103/CJP.CJP_98_19
Lin CY, et al. Muscle Type From Which Satellite Cells Are Derived Plays a Role in Their Damage Response. Chin J Physiol. 2020 May-Jun;63(3):113-121. PubMed PMID: 32594064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscle type from which satellite cells are derived plays a role in their damage response. AU - Lin,Chuang-Yu, AU - Hou,Chun-Yin, AU - Tsai,Chung-Min, AU - Chang,Hsi, PY - 2020/6/29/entrez PY - 2020/7/1/pubmed PY - 2020/7/1/medline KW - Denervation-induced atrophy model KW - Pax3 and Pax7 KW - disuse-induced atrophy model KW - muscle regeneration KW - muscle type SP - 113 EP - 121 JF - The Chinese journal of physiology JO - Chin J Physiol VL - 63 IS - 3 N2 - The aim of this study was to evaluate the response of satellite cells to muscular atrophies which possess different pathological characteristics and which were induced by distinct damages. Right lower limbs of rats were exposed to denervation or disuse and later its tibialis anterior (TA) or soleus (SOL) muscles were analyzed. After confirming their functional impairments indicated by common but distinct pathological and electrophysiological characteristics, the quantitative polymerase chain reaction analysis of Pax7 and Pax3 expressions and the number of Pax7+ve and Pax3+ve cells were analyzed sequentially at day 0, day 7, and day 14. TA muscles of both denervation- and disuse-induced atrophy models showed persisted low level of Pax7 expression from day 7 (0.91 ± 0.23 and 0.31 ± 0.07, P = 0.06, n = 6) through day 14 (1.09 ± 0.15 and 0.4 ± 0.09 [P < 0.05]). On the other hand, significant elevations were observed in Pax3 expression in both atrophy models (2.73 ± 0.46 and 2.75 ± 0.26 [P < 0.05]) at day 7. Similar to TA muscle, resembled pattern of Pax7 and Pax3 expression changes were observed between the SOL muscles of denervation- and disused-atrophy models. These trends were further confirmed by the changes in Pax7+ve and Pax3+ve cell numbers of TA and SOL muscles in both atrophy models. Despite the distinct pathological findings, similar patterns in the changes of Pax3 and Pax7 expressions and the changes of Pax7+ve and Pax3+ve cell numbers were observed between the denervation- and disuse-induced atrophy models and this commonality was admitted among the muscle type. Therefore, we claim that the muscle regeneration orchestrated by satellite cells was governed by the muscle type in which satellite cells reside. SN - 0304-4920 UR - https://www.unboundmedicine.com/medline/citation/32594064/Muscle_type_from_which_satellite_cells_are_derived_plays_a_role_in_their_damage_response L2 - http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2020;volume=63;issue=3;spage=113;epage=121;aulast=Lin DB - PRIME DP - Unbound Medicine ER -
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