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Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model.
Biol Trace Elem Res. 2020 Jun 27 [Online ahead of print]BT

Abstract

The aim of this study was to evaluate the effects of aluminum sulfate (alum) with propolis (PR) on uterine leiomyoma (UL) in rat model. One hundred and four female Wistar rats (180-200 g) were allocated into two main groups of control (Co, n = 8) and experiment (UL model [estradiol benzoate 200 μg/kg/IM twice/week/8 weeks] with/without treatment) defined in 13 subgroups with/without treatment with coil oil (UL + COi), PR (100 or 200 mg/kg) as UL + PR100 or 200, alum (35, 75 or 150 mg/Kg) as UL + AL 35, 75, or 150, and PR (100 mg/kg or 200) with alum (35, 75, or 150 mg/Kg) as UL + PR100 or 200 + AL35, 75, or 150. Subgroups received doses of therapeutics for 14 days (IP). In the end, rats were sacrificed, and the uteri were isolated for molecular and histopathological investigations. The myometrium thickness, collagen contents, and gene expression of MMP-2 and 9 increased significantly in experimental groups with/without treatment (P ˂ 0.05). PR administration (100 and 200 mg/kg) alone or with alum (35 and 75 mg/kg) significantly decreased myometrium collagen contents and the gene expression and protein concentration of MMP-2 and 9 compared with UL and UL + Coi subgroups (P ˂ 0.05). Alum (75 mg/kg) with PR (200 mg/kg) could improve UL features and reduce MMP-2 and 9 gene expression.

Authors+Show Affiliations

Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran. Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.Department of Pathology, Semnan University of Medical Sciences, Semnan, Iran.Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.Department of Medical Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran. Hoda.d8827@semums.ac.ir. Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Hoda.d8827@semums.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32594359

Citation

Yousefi, Behpour, et al. "Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model." Biological Trace Element Research, 2020.
Yousefi B, Semnani V, Mokhtari T, et al. Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model. Biol Trace Elem Res. 2020.
Yousefi, B., Semnani, V., Mokhtari, T., Zarbakhsh, S., Amjad, M. H. T., Barati, M., & Doustmohammadi, H. (2020). Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model. Biological Trace Element Research. https://doi.org/10.1007/s12011-020-02200-0
Yousefi B, et al. Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model. Biol Trace Elem Res. 2020 Jun 27; PubMed PMID: 32594359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model. AU - Yousefi,Behpour, AU - Semnani,Vahid, AU - Mokhtari,Tahmineh, AU - Zarbakhsh,Sam, AU - Amjad,Mohammad Hasan Tabrizi, AU - Barati,Mehdi, AU - Doustmohammadi,Hoda, Y1 - 2020/06/27/ PY - 2020/02/08/received PY - 2020/05/14/accepted PY - 2020/6/29/entrez KW - Aluminum sulfate KW - Matrix metalloproteinases KW - Propolis KW - Rat KW - Uterine leiomyoma JF - Biological trace element research JO - Biol Trace Elem Res N2 - The aim of this study was to evaluate the effects of aluminum sulfate (alum) with propolis (PR) on uterine leiomyoma (UL) in rat model. One hundred and four female Wistar rats (180-200 g) were allocated into two main groups of control (Co, n = 8) and experiment (UL model [estradiol benzoate 200 μg/kg/IM twice/week/8 weeks] with/without treatment) defined in 13 subgroups with/without treatment with coil oil (UL + COi), PR (100 or 200 mg/kg) as UL + PR100 or 200, alum (35, 75 or 150 mg/Kg) as UL + AL 35, 75, or 150, and PR (100 mg/kg or 200) with alum (35, 75, or 150 mg/Kg) as UL + PR100 or 200 + AL35, 75, or 150. Subgroups received doses of therapeutics for 14 days (IP). In the end, rats were sacrificed, and the uteri were isolated for molecular and histopathological investigations. The myometrium thickness, collagen contents, and gene expression of MMP-2 and 9 increased significantly in experimental groups with/without treatment (P ˂ 0.05). PR administration (100 and 200 mg/kg) alone or with alum (35 and 75 mg/kg) significantly decreased myometrium collagen contents and the gene expression and protein concentration of MMP-2 and 9 compared with UL and UL + Coi subgroups (P ˂ 0.05). Alum (75 mg/kg) with PR (200 mg/kg) could improve UL features and reduce MMP-2 and 9 gene expression. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/32594359/Co-administration_of_Aluminum_Sulfate_and_Propolis_Regulates_Matrix_Metalloproteinases-2/9_Expression_and_Improves_the_Uterine_Leiomyoma_in_Adult_Rat_Model L2 - https://dx.doi.org/10.1007/s12011-020-02200-0 DB - PRIME DP - Unbound Medicine ER -
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