Tags

Type your tag names separated by a space and hit enter

The Role of Clozapine as a Mood Regulator in the Treatment of Rapid Cycling Bipolar Affective Disorder.
Turk Psikiyatri Derg. 2019 Winter; 30(4):268-271.TP

Abstract

OBJECTIVE

In this study, we aimed to investigate the effect of the clozapine on the course of the rapid cycling Bipolar Affective Disorder.

METHOD

The study group was formed with the patients aged between 18 and 65 years of age, who met the criteria for the diagnosis of Bipolar Affective Disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th Edition, with rapid cycling characteristics. Variables like the number of mania and depressive episodes, the days spent in mania and in depression and the number of hospitalization and attempted suicide, in the year before starting clozapine were determined and compared with the annual data after starting the clozapine.

RESULTS

Eleven female and two male patients who met the inclusion criteria were included in this study. The group`s average daily use of clozapine was 180 mg (25-600 mg). There was a statistically significant difference in the number of days spent in the depression, the days spent in the mania, the number of depressive episodes and manic episodes, the number of hospitalizations and the suicide attempts after the clozapine use.

CONCLUSION

In this study, it was determined that clozapine was effective as a mood stabilizer in Bipolar Affective Disorder treatment. The results show that clozapine reduces the episode frequency and the duration in rapid cycling Bipolar Affective Disorder which does not respond to all conventional treatments, including lithium, valproic acid, carbamazepine and antipsychotic drugs.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng tur

PubMed ID

32594488

Citation

Kılınçel, Oğuzhan, et al. "The Role of Clozapine as a Mood Regulator in the Treatment of Rapid Cycling Bipolar Affective Disorder." Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry, vol. 30, no. 4, 2019, pp. 268-271.
Kılınçel O, Kılınçel Ş, Gündüz C, et al. The Role of Clozapine as a Mood Regulator in the Treatment of Rapid Cycling Bipolar Affective Disorder. Turk Psikiyatri Derg. 2019;30(4):268-271.
Kılınçel, O., Kılınçel, Ş., Gündüz, C., Cangür, Ş., & Akkaya, C. (2019). The Role of Clozapine as a Mood Regulator in the Treatment of Rapid Cycling Bipolar Affective Disorder. Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry, 30(4), 268-271.
Kılınçel O, et al. The Role of Clozapine as a Mood Regulator in the Treatment of Rapid Cycling Bipolar Affective Disorder. Turk Psikiyatri Derg. 2019;30(4):268-271. PubMed PMID: 32594488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Clozapine as a Mood Regulator in the Treatment of Rapid Cycling Bipolar Affective Disorder. AU - Kılınçel,Oğuzhan, AU - Kılınçel,Şenay, AU - Gündüz,Cem, AU - Cangür,Şengül, AU - Akkaya,Cengiz, PY - 2020/6/29/entrez SP - 268 EP - 271 JF - Turk psikiyatri dergisi = Turkish journal of psychiatry JO - Turk Psikiyatri Derg VL - 30 IS - 4 N2 - OBJECTIVE: In this study, we aimed to investigate the effect of the clozapine on the course of the rapid cycling Bipolar Affective Disorder. METHOD: The study group was formed with the patients aged between 18 and 65 years of age, who met the criteria for the diagnosis of Bipolar Affective Disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th Edition, with rapid cycling characteristics. Variables like the number of mania and depressive episodes, the days spent in mania and in depression and the number of hospitalization and attempted suicide, in the year before starting clozapine were determined and compared with the annual data after starting the clozapine. RESULTS: Eleven female and two male patients who met the inclusion criteria were included in this study. The group`s average daily use of clozapine was 180 mg (25-600 mg). There was a statistically significant difference in the number of days spent in the depression, the days spent in the mania, the number of depressive episodes and manic episodes, the number of hospitalizations and the suicide attempts after the clozapine use. CONCLUSION: In this study, it was determined that clozapine was effective as a mood stabilizer in Bipolar Affective Disorder treatment. The results show that clozapine reduces the episode frequency and the duration in rapid cycling Bipolar Affective Disorder which does not respond to all conventional treatments, including lithium, valproic acid, carbamazepine and antipsychotic drugs. SN - 1300-2163 UR - https://www.unboundmedicine.com/medline/citation/32594488/The_Role_of_Clozapine_as_a_Mood_Regulator_in_the_Treatment_of_Rapid_Cycling_Bipolar_Affective_Disorder L2 - http://www.turkpsikiyatri.com/ftr.aspx?id=1183 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.