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Factors associated with severity and resolution of intramuscular injection site pain following treatment for uncomplicated gonorrhoea: a prospective cohort study of GToG trial participants.
Sex Health. 2020 Jun 29 [Online ahead of print]SH

Abstract

Background:

Intramuscular injection (IMI) pain reduces the acceptability of treatment, but data identifying those at highest risk of severe pain following an injection are limited. This study identified factors associated with the severity, duration and resolution of IMI pain following treatment for uncomplicated gonorrhoea.

Methods:

Data from a subset of participants (aged 16-70 years) recruited between October 2014 and November 2016 into the 'Gentamicin for the treatment of gonorrhoea' trial in England were analysed. Pain was measured using a visual analogue scale (VAS) immediately after injection. Self-reported duration of pain was collected at a scheduled 2-week follow-up visit.

Results:

Overall, 688 participants (82% male), reported a median pain VAS score of 23.5 (range 0-100), which was moderate-severe (VAS score >30) in 38% (262/688) of participants. Age [adjusted odds ratio (aOR) 0.86 per 5-yearly increase, (0.78-0.94)], gender [female cf. male, aOR 1.62 (1.18-2.24)], ethnicity [Asian cf. Caucasian, aOR 2.79 (1.72-4.51)], body mass index [aOR 0.80 per 5 kgm-2 increase, (0.72-0.89)] and antibiotic regimen [gentamicin cf. ceftriaxone, aOR 3.92, (3.12-4.93)] were associated with moderate-severe injection pain. The median duration of pain was 2 h (range 0-648). Gender [female cf. male, adjusted hazard ratio (aHR) 0.76 (0.57-1.00)], ethnicity [Mixed race cf. Caucasian, aHR 0.64 (0.45-0.92)], self-reported pain [aHR 0.97 per 10 mm VAS score increase, (0.95-0.99)] and symptom status [asymptomatic cf. symptomatic aHR 1.35 (1.12-1.64)] were associated with pain resolution.

Conclusions:

IMI pain is influenced by specific demographic, anthropometric and clinical factors. Knowledge of these factors will help identify those most at risk of pain.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32594971

Citation

Ayinde, Oluseyi, and Jonathan D C. Ross. "Factors Associated With Severity and Resolution of Intramuscular Injection Site Pain Following Treatment for Uncomplicated Gonorrhoea: a Prospective Cohort Study of GToG Trial Participants." Sexual Health, 2020.
Ayinde O, Ross JDC. Factors associated with severity and resolution of intramuscular injection site pain following treatment for uncomplicated gonorrhoea: a prospective cohort study of GToG trial participants. Sex Health. 2020.
Ayinde, O., & Ross, J. D. C. (2020). Factors associated with severity and resolution of intramuscular injection site pain following treatment for uncomplicated gonorrhoea: a prospective cohort study of GToG trial participants. Sexual Health. https://doi.org/10.1071/SH19176
Ayinde O, Ross JDC. Factors Associated With Severity and Resolution of Intramuscular Injection Site Pain Following Treatment for Uncomplicated Gonorrhoea: a Prospective Cohort Study of GToG Trial Participants. Sex Health. 2020 Jun 29; PubMed PMID: 32594971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with severity and resolution of intramuscular injection site pain following treatment for uncomplicated gonorrhoea: a prospective cohort study of GToG trial participants. AU - Ayinde,Oluseyi, AU - Ross,Jonathan D C, Y1 - 2020/06/29/ PY - 2019/10/10/received PY - 2020/04/30/accepted PY - 2020/6/30/entrez JF - Sexual health JO - Sex Health N2 - Background:Intramuscular injection (IMI) pain reduces the acceptability of treatment, but data identifying those at highest risk of severe pain following an injection are limited. This study identified factors associated with the severity, duration and resolution of IMI pain following treatment for uncomplicated gonorrhoea. Methods: Data from a subset of participants (aged 16-70 years) recruited between October 2014 and November 2016 into the 'Gentamicin for the treatment of gonorrhoea' trial in England were analysed. Pain was measured using a visual analogue scale (VAS) immediately after injection. Self-reported duration of pain was collected at a scheduled 2-week follow-up visit. Results: Overall, 688 participants (82% male), reported a median pain VAS score of 23.5 (range 0-100), which was moderate-severe (VAS score >30) in 38% (262/688) of participants. Age [adjusted odds ratio (aOR) 0.86 per 5-yearly increase, (0.78-0.94)], gender [female cf. male, aOR 1.62 (1.18-2.24)], ethnicity [Asian cf. Caucasian, aOR 2.79 (1.72-4.51)], body mass index [aOR 0.80 per 5 kgm-2 increase, (0.72-0.89)] and antibiotic regimen [gentamicin cf. ceftriaxone, aOR 3.92, (3.12-4.93)] were associated with moderate-severe injection pain. The median duration of pain was 2 h (range 0-648). Gender [female cf. male, adjusted hazard ratio (aHR) 0.76 (0.57-1.00)], ethnicity [Mixed race cf. Caucasian, aHR 0.64 (0.45-0.92)], self-reported pain [aHR 0.97 per 10 mm VAS score increase, (0.95-0.99)] and symptom status [asymptomatic cf. symptomatic aHR 1.35 (1.12-1.64)] were associated with pain resolution. Conclusions: IMI pain is influenced by specific demographic, anthropometric and clinical factors. Knowledge of these factors will help identify those most at risk of pain. SN - 1449-8987 UR - https://www.unboundmedicine.com/medline/citation/32594971/Factors_associated_with_severity_and_resolution_of_intramuscular_injection_site_pain_following_treatment_for_uncomplicated_gonorrhoea:_a_prospective_cohort_study_of_GToG_trial_participants DB - PRIME DP - Unbound Medicine ER -
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