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Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome.
J Atheroscler Thromb. 2020 Nov 01; 27(11):1216-1229.JA

Abstract

AIMS

We evaluated the relationship between the ratios of eicosapentaenoic acid and arachidonic acid (EPA/AA), docosahexaenoic acid (DHA)/AA, and delta-5 desaturase activity (D5D) and atherogenic lipid profiles (ALP) and coronary atherosclerosis.

METHODS

Polyunsaturated fatty acids (PUFA) and ALP were assessed in 436 men with the first episode of acute coronary syndrome (ACS) not take any lipid-lowering drugs. D5D was estimated as the ratio of AA to dihomogamma-linolenic acid (DGLA). These biomarkers were compared between the lower and higher levels of EPA/AA (0.41) or DHA/AA (0.93) according to the levels in Japanese general population. The thrombolysis in myocardial infarction flow (TIMI) grade of the culprit coronary artery was visually estimated during the initial angiography.

RESULTS

Approximately 70% of patients had low EPA/AA or DHA/AA. Serum levels of LDL-cholesterol, apolipoprotein B (apoB), and remnant lipoprotein cholesterol (RL-C) were significantly higher in the low EPA/AA or DHA/AA groups, while those of triglycerides and malondialdehyde-modified LDL (MDA-LDL) were significantly higher in the low EPA/AA group alone. The levels of EPA, EPA/AA, DHA/AA, and HbA1c increased and those of DGLA and apoA1 decreased with increasing number of stenotic vessels. Patients with three stenotic coronary vessels or TIMI grade ≥ 1 had significantly higher EPA levels compared with the others. The levels of LDL-cholesterol, non-HDL-cholesterol, triglycerides, small dense LDL-cholesterol, RL-C, MDA-LDL, apoB, and apoE decreased progressively and those of EPA, DHA, EPA/AA and HDL-cholesterol increased as D5D increased.

CONCLUSIONS

The EPA/AA is a superior risk marker than DHA/AA in term of correlation with ALP in ACS patients.

Authors+Show Affiliations

Department of Medicine, Division of Cardiology, Showa University School of Medicine.Department of Medicine, Division of Cardiology, Showa University School of Medicine.Department of Medicine, Division of Cardiology, Showa University School of Medicine.Department of Medicine, Division of Cardiology, Showa University School of Medicine.Department of Medicine, Division of Cardiology, Showa University School of Medicine.Department of Medicine, Division of Cardiology, Showa University School of Medicine.Department of Medicine, Division of Cardiology, Showa University School of Medicine.Department of Medicine, Division of Cardiology, Showa University School of Medicine.Department of Medicine, Division of Cardiology, Showa University School of Medicine.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

32595194

Citation

Arai, Ken, et al. "Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men With Acute Coronary Syndrome." Journal of Atherosclerosis and Thrombosis, vol. 27, no. 11, 2020, pp. 1216-1229.
Arai K, Koba S, Yokota Y, et al. Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome. J Atheroscler Thromb. 2020;27(11):1216-1229.
Arai, K., Koba, S., Yokota, Y., Tsunoda, F., Tsujita, H., Kondo, S., Tsukamoto, S., Shoji, M., & Shinke, T. (2020). Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome. Journal of Atherosclerosis and Thrombosis, 27(11), 1216-1229. https://doi.org/10.5551/jat.55780
Arai K, et al. Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men With Acute Coronary Syndrome. J Atheroscler Thromb. 2020 Nov 1;27(11):1216-1229. PubMed PMID: 32595194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome. AU - Arai,Ken, AU - Koba,Shinji, AU - Yokota,Yuya, AU - Tsunoda,Fumiyoshi, AU - Tsujita,Hiroaki, AU - Kondo,Seita, AU - Tsukamoto,Shigeto, AU - Shoji,Makoto, AU - Shinke,Toshiro, Y1 - 2020/06/27/ PY - 2020/7/1/pubmed PY - 2021/9/28/medline PY - 2020/6/30/entrez KW - Acute coronary syndrome KW - Arachidonic acid KW - Delta-5 KW - Docosahexaenoic acid KW - Eicosapentaenoic acid SP - 1216 EP - 1229 JF - Journal of atherosclerosis and thrombosis JO - J Atheroscler Thromb VL - 27 IS - 11 N2 - AIMS: We evaluated the relationship between the ratios of eicosapentaenoic acid and arachidonic acid (EPA/AA), docosahexaenoic acid (DHA)/AA, and delta-5 desaturase activity (D5D) and atherogenic lipid profiles (ALP) and coronary atherosclerosis. METHODS: Polyunsaturated fatty acids (PUFA) and ALP were assessed in 436 men with the first episode of acute coronary syndrome (ACS) not take any lipid-lowering drugs. D5D was estimated as the ratio of AA to dihomogamma-linolenic acid (DGLA). These biomarkers were compared between the lower and higher levels of EPA/AA (0.41) or DHA/AA (0.93) according to the levels in Japanese general population. The thrombolysis in myocardial infarction flow (TIMI) grade of the culprit coronary artery was visually estimated during the initial angiography. RESULTS: Approximately 70% of patients had low EPA/AA or DHA/AA. Serum levels of LDL-cholesterol, apolipoprotein B (apoB), and remnant lipoprotein cholesterol (RL-C) were significantly higher in the low EPA/AA or DHA/AA groups, while those of triglycerides and malondialdehyde-modified LDL (MDA-LDL) were significantly higher in the low EPA/AA group alone. The levels of EPA, EPA/AA, DHA/AA, and HbA1c increased and those of DGLA and apoA1 decreased with increasing number of stenotic vessels. Patients with three stenotic coronary vessels or TIMI grade ≥ 1 had significantly higher EPA levels compared with the others. The levels of LDL-cholesterol, non-HDL-cholesterol, triglycerides, small dense LDL-cholesterol, RL-C, MDA-LDL, apoB, and apoE decreased progressively and those of EPA, DHA, EPA/AA and HDL-cholesterol increased as D5D increased. CONCLUSIONS: The EPA/AA is a superior risk marker than DHA/AA in term of correlation with ALP in ACS patients. SN - 1880-3873 UR - https://www.unboundmedicine.com/medline/citation/32595194/Relationships_of_Fatty_Acids_Delta_5_Desaturase_Activity_and_Lipid_Profiles_in_Men_with_Acute_Coronary_Syndrome_ L2 - https://dx.doi.org/10.5551/jat.55780 DB - PRIME DP - Unbound Medicine ER -