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Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.
Hum Brain Mapp. 2020 Jun 29 [Online ahead of print]HB

Abstract

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

Authors+Show Affiliations

National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.Leiden University Medical Center, Department of Psychiatry, Leiden, The Netherlands. Leiden Institute for Brain and Cognition (LIBC), Leiden, The Netherlands. Leiden University, Institute of Psychology, Developmental and Educational Psychology, Leiden, The Netherlands.Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.Department. of Psychiatry, Amsterdam UMC/VUMC, Amsterdam, The Netherlands. GGZ InGeest, Department of Research & Innovation, Amsterdam, The Netherlands.Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.Department of Mental Health, University Hospital Parc Taulí-I3PT, Barcelona, Spain. Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.Department of Mental Health, University Hospital Parc Taulí-I3PT, Barcelona, Spain. Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska, USA.Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska, USA.Department of Psychiatry, New York University, New York, New York, USA.Department of Psychiatry, New York University, New York, New York, USA.Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA.Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA.Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA.Behavioral Epidemiology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, California, USA.Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.Department of Psychology, Harvard University, Cambridge, Massachusetts, USA. Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.Department of Psychology, Harvard University, Cambridge, Massachusetts, USA. Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.LiNC, Department of Psychiatry, Federal University of São Paulo, São Paulo, São Paulo, Brazil.LiNC, Department of Psychiatry, Federal University of São Paulo, São Paulo, São Paulo, Brazil.Section on Negative Affect and Social Processes, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut, USA. Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.Anxiety Disorders Center, Institute of Living, Hartford Hospital, Hartford, Connecticut, USA. Yale School of Medicine, New Haven, Connecticut, USA.Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany.Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany.Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Department of Psychiatry & Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Anxiety Disorder Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.Centre for Neuroimaging Science, Kings College London, London, UK.Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.School of Psychology, University of Sussex, Brighton, UK.Department of Psychology, Sapienza University of Rome, Rome, Italy.Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy. Vita-Salute San Raffaele University, Milan, Italy.Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy. Vita-Salute San Raffaele University, Milan, Italy. Neurology and Neurophysiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.Institute of Mental Health, University of Belgrade, Belgrade, Serbia. Department of Psychiatry, School of Medicine, University of Belgrade, Belgrade, Serbia.Institute of Mental Health, University of Belgrade, Belgrade, Serbia.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.Graduate Program in Electrical and Computer Engineering, Universidade Tecnológica Federal do Paraná, Curitiba, Puerto Rico, Brazil.Center for Neuromodulation in Depression and Stress, University of Pennsylvania, Philadelphia, Pennsylvania, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.Department of Physics, Stony Brook University, Stony Brook, New York, USA.Department of Psychiatry, The University of Texas at Austin Dell Medical School, Austin, Texas, USA.Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.Department of Psychiatry & Family Medicine and Public Health, University of California, La Jolla, California, USA.Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Department of Psychiatry, Washington University, St. Louis, Missouri, USA.Department of Psychiatry, Washington University, St. Louis, Missouri, USA.Department of Psychiatry, Washington University, St. Louis, Missouri, USA.Department of Psychiatry, Washington University, St. Louis, Missouri, USA.Department of Psychiatry, Washington University, St. Louis, Missouri, USA.Department. of Psychiatry, Amsterdam UMC/VUMC, Amsterdam, The Netherlands.Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.Leiden University Medical Center, Department of Psychiatry, Leiden, The Netherlands. Leiden Institute for Brain and Cognition (LIBC), Leiden, The Netherlands.Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa. SAMRC Unite on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, California, USA.Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, California, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32596977

Citation

Zugman, André, et al. "Mega-analysis Methods in ENIGMA: the Experience of the Generalized Anxiety Disorder Working Group." Human Brain Mapping, 2020.
Zugman A, Harrewijn A, Cardinale EM, et al. Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. Hum Brain Mapp. 2020.
Zugman, A., Harrewijn, A., Cardinale, E. M., Zwiebel, H., Freitag, G. F., Werwath, K. E., Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Hilbert, K., Cardoner, N., Porta-Casteràs, D., Gosnell, S., Salas, R., Blair, K. S., Blair, J. R., Hammoud, M. Z., Milad, M., Burkhouse, K., ... Winkler, A. M. (2020). Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. Human Brain Mapping. https://doi.org/10.1002/hbm.25096
Zugman A, et al. Mega-analysis Methods in ENIGMA: the Experience of the Generalized Anxiety Disorder Working Group. Hum Brain Mapp. 2020 Jun 29; PubMed PMID: 32596977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. AU - Zugman,André, AU - Harrewijn,Anita, AU - Cardinale,Elise M, AU - Zwiebel,Hannah, AU - Freitag,Gabrielle F, AU - Werwath,Katy E, AU - Bas-Hoogendam,Janna M, AU - Groenewold,Nynke A, AU - Aghajani,Moji, AU - Hilbert,Kevin, AU - Cardoner,Narcis, AU - Porta-Casteràs,Daniel, AU - Gosnell,Savannah, AU - Salas,Ramiro, AU - Blair,Karina S, AU - Blair,James R, AU - Hammoud,Mira Z, AU - Milad,Mohammed, AU - Burkhouse,Katie, AU - Phan,K Luan, AU - Schroeder,Heidi K, AU - Strawn,Jeffrey R, AU - Beesdo-Baum,Katja, AU - Thomopoulos,Sophia I, AU - Grabe,Hans J, AU - Van der Auwera,Sandra, AU - Wittfeld,Katharina, AU - Nielsen,Jared A, AU - Buckner,Randy, AU - Smoller,Jordan W, AU - Mwangi,Benson, AU - Soares,Jair C, AU - Wu,Mon-Ju, AU - Zunta-Soares,Giovana B, AU - Jackowski,Andrea P, AU - Pan,Pedro M, AU - Salum,Giovanni A, AU - Assaf,Michal, AU - Diefenbach,Gretchen J, AU - Brambilla,Paolo, AU - Maggioni,Eleonora, AU - Hofmann,David, AU - Straube,Thomas, AU - Andreescu,Carmen, AU - Berta,Rachel, AU - Tamburo,Erica, AU - Price,Rebecca, AU - Manfro,Gisele G, AU - Critchley,Hugo D, AU - Makovac,Elena, AU - Mancini,Matteo, AU - Meeten,Frances, AU - Ottaviani,Cristina, AU - Agosta,Federica, AU - Canu,Elisa, AU - Cividini,Camilla, AU - Filippi,Massimo, AU - Kostić,Milutin, AU - Munjiza,Ana, AU - Filippi,Courtney A, AU - Leibenluft,Ellen, AU - Alberton,Bianca A V, AU - Balderston,Nicholas L, AU - Ernst,Monique, AU - Grillon,Christian, AU - Mujica-Parodi,Lilianne R, AU - van Nieuwenhuizen,Helena, AU - Fonzo,Gregory A, AU - Paulus,Martin P, AU - Stein,Murray B, AU - Gur,Raquel E, AU - Gur,Ruben C, AU - Kaczkurkin,Antonia N, AU - Larsen,Bart, AU - Satterthwaite,Theodore D, AU - Harper,Jennifer, AU - Myers,Michael, AU - Perino,Michael T, AU - Yu,Qiongru, AU - Sylvester,Chad M, AU - Veltman,Dick J, AU - Lueken,Ulrike, AU - Van der Wee,Nic J A, AU - Stein,Dan J, AU - Jahanshad,Neda, AU - Thompson,Paul M, AU - Pine,Daniel S, AU - Winkler,Anderson M, Y1 - 2020/06/29/ PY - 2020/03/02/received PY - 2020/05/26/revised PY - 2020/05/31/accepted PY - 2020/7/1/pubmed PY - 2020/7/1/medline PY - 2020/6/30/entrez KW - data sharing KW - generalized anxiety disorder KW - mega-analyses KW - meta-analyses KW - neuroimaging JF - Human brain mapping JO - Hum Brain Mapp N2 - The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/32596977/Mega-analysis_methods_in_ENIGMA:_The_experience_of_the_generalized_anxiety_disorder_working_group L2 - https://doi.org/10.1002/hbm.25096 DB - PRIME DP - Unbound Medicine ER -