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The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study.
J Korean Med Sci. 2020 Jun 29; 35(25):e236.JK

Abstract

BACKGROUND

Coronavirus disease-2019 (COVID-19) pandemic has affected millions of people throughout the world since December 2019. However, there is a limited amount of data about pediatric patients infected with the disease agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

METHODS

The epidemiological, laboratory, radiological, and treatment features of the pediatric patients who were positive for SARS-CoV-2 based on the reverse-transcription polymerase chain reaction (RT-PCR) test, were investigated retrospectively.

RESULTS

The median age of 81 children included in the study was 9.50 years (0-17.75 years). The most frequent symptoms at the time of admission were fever (58%), cough (52%), and fatigue or myalgia (19%). The abnormal laboratory findings in these cases were decreased lymphocytes (2.5%, n = 2), leucopenia (5%, n = 4), and increased lactate dehydrogenase (17.2%, n = 14), C-reactive protein (16%, n = 13), procalcitonin (3.7%, n = 3), and D-dimer (12.3%, n = 10). Three (4%) patients had consolidation in chest computed tomography, and three (4%) had ground-glass opacities. None of the patients needed intensive care except for the newborns. The median time to turn SARS-CoV-2 negative in the RT-PCR test was 5 (3-10) days. The median length of hospital stay was 5 (4-10) days. The time to turn SARS-CoV-2 negative in the RT-PCR test and the length of hospital stay were significantly longer for those aged five years or younger than others (P = 0.037, P = 0.01).

CONCLUSION

Compared to adults, COVID-19 is milder and more distinctive in children. As a result, more conservative approaches might be preferred in children for the diagnostic, clinical, and even therapeutic applications.

Authors+Show Affiliations

Department of Pediatrics, Bursa City Hospital, Bursa, Turkey. korkmazmfurkan@gmail.com.Department of Pediatric Emergency, Bursa City Hospital, Bursa, Turkey.Department of Neonatology, Bursa City Hospital, Bursa, Turkey.Department of Clinical Microbiology, Bursa City Hospital, Bursa, Turkey.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

32597047

Citation

Korkmaz, Muhammet Furkan, et al. "The Epidemiological and Clinical Characteristics of 81 Children With COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study." Journal of Korean Medical Science, vol. 35, no. 25, 2020, pp. e236.
Korkmaz MF, Türe E, Dorum BA, et al. The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study. J Korean Med Sci. 2020;35(25):e236.
Korkmaz, M. F., Türe, E., Dorum, B. A., & Kılıç, Z. B. (2020). The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study. Journal of Korean Medical Science, 35(25), e236. https://doi.org/10.3346/jkms.2020.35.e236
Korkmaz MF, et al. The Epidemiological and Clinical Characteristics of 81 Children With COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study. J Korean Med Sci. 2020 Jun 29;35(25):e236. PubMed PMID: 32597047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study. AU - Korkmaz,Muhammet Furkan, AU - Türe,Esra, AU - Dorum,Bayram Ali, AU - Kılıç,Zeliha Banu, Y1 - 2020/06/29/ PY - 2020/05/26/received PY - 2020/06/15/accepted PY - 2020/6/30/entrez PY - 2020/7/1/pubmed PY - 2020/7/7/medline KW - COVID-19 KW - Children KW - Clinical Symptoms KW - Coronavirus KW - Newborn KW - SARS-CoV-2 SP - e236 EP - e236 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 35 IS - 25 N2 - BACKGROUND: Coronavirus disease-2019 (COVID-19) pandemic has affected millions of people throughout the world since December 2019. However, there is a limited amount of data about pediatric patients infected with the disease agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: The epidemiological, laboratory, radiological, and treatment features of the pediatric patients who were positive for SARS-CoV-2 based on the reverse-transcription polymerase chain reaction (RT-PCR) test, were investigated retrospectively. RESULTS: The median age of 81 children included in the study was 9.50 years (0-17.75 years). The most frequent symptoms at the time of admission were fever (58%), cough (52%), and fatigue or myalgia (19%). The abnormal laboratory findings in these cases were decreased lymphocytes (2.5%, n = 2), leucopenia (5%, n = 4), and increased lactate dehydrogenase (17.2%, n = 14), C-reactive protein (16%, n = 13), procalcitonin (3.7%, n = 3), and D-dimer (12.3%, n = 10). Three (4%) patients had consolidation in chest computed tomography, and three (4%) had ground-glass opacities. None of the patients needed intensive care except for the newborns. The median time to turn SARS-CoV-2 negative in the RT-PCR test was 5 (3-10) days. The median length of hospital stay was 5 (4-10) days. The time to turn SARS-CoV-2 negative in the RT-PCR test and the length of hospital stay were significantly longer for those aged five years or younger than others (P = 0.037, P = 0.01). CONCLUSION: Compared to adults, COVID-19 is milder and more distinctive in children. As a result, more conservative approaches might be preferred in children for the diagnostic, clinical, and even therapeutic applications. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/32597047/The_Epidemiological_and_Clinical_Characteristics_of_81_Children_with_COVID_19_in_a_Pandemic_Hospital_in_Turkey:_an_Observational_Cohort_Study_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e236 DB - PRIME DP - Unbound Medicine ER -