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Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluation.
Drug Dev Ind Pharm. 2020 Aug; 46(8):1253-1264.DD

Abstract

OBJECTIVE

The inkjet printing (IP) and fused deposition modeling (FDM) technologies have emerged in the pharmaceutical field as novel and personalized formulation approaches. Specific manufacturing factors must be considered in each adopted methodology, i.e. the development of suitable substrates for IP and the incorporation of highly thermostable active pharmaceutical compounds (APIs) for FDM. In this study, IP and FDM printing technologies were investigated for the fabrication of hydroxypropyl methylcellulose-based mucoadhesive films for the buccal delivery of a thermolabile model drug. Significance: This proof-of-concept approach was expected to provide an alternative formulation methodology for personalized mucoadhesive buccal films.

METHODS

Mucoadhesive substrates were prepared by FDM and were subjected to sequential IP of an ibuprofen-loaded liquid ink. The interactions between these processes and the performance of the films were evaluated by various analytical and spectroscopic techniques, as well as by in vitro and ex vivo studies.

RESULTS

The model drug was efficiently deposited by sequential IP passes onto the FDM-printed substrates. Significant variations were revealed on the morphological, physicochemical and mechanical properties of the prepared films, and linked to the number of IP passes. The mechanism of drug release, the mucoadhesion and the permeation of the drug through the buccal epithelium were evaluated, in view of the extent of ink deposition onto the buccal films, as well as the distribution of the API.

CONCLUSIONS

The presented methodology provided a proof-of-concept formulation approach for the development of personalized mucoadhesive films.

Authors+Show Affiliations

Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.School of Science and Technology, International Hellenic University, Thermi, Greece.Department of Food Science and Technology, International Hellenic University, Thessaloniki, Greece.Department of Materials Science, University of Patras, Patras, Greece. Foundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature Chemical Processes, Patras, Greece.Foundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature Chemical Processes, Patras, Greece.Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32597338

Citation

Eleftheriadis, Georgios K., et al. "Inkjet Printing of a Thermolabile Model Drug Onto FDM-printed Substrates: Formulation and Evaluation." Drug Development and Industrial Pharmacy, vol. 46, no. 8, 2020, pp. 1253-1264.
Eleftheriadis GK, Katsiotis CS, Andreadis DA, et al. Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluation. Drug Dev Ind Pharm. 2020;46(8):1253-1264.
Eleftheriadis, G. K., Katsiotis, C. S., Andreadis, D. A., Tzetzis, D., Ritzoulis, C., Bouropoulos, N., Kanellopoulou, D., Andriotis, E. G., Tsibouklis, J., & Fatouros, D. G. (2020). Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluation. Drug Development and Industrial Pharmacy, 46(8), 1253-1264. https://doi.org/10.1080/03639045.2020.1788062
Eleftheriadis GK, et al. Inkjet Printing of a Thermolabile Model Drug Onto FDM-printed Substrates: Formulation and Evaluation. Drug Dev Ind Pharm. 2020;46(8):1253-1264. PubMed PMID: 32597338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inkjet printing of a thermolabile model drug onto FDM-printed substrates: formulation and evaluation. AU - Eleftheriadis,Georgios K, AU - Katsiotis,Christos S, AU - Andreadis,Dimitrios A, AU - Tzetzis,Dimitrios, AU - Ritzoulis,Christos, AU - Bouropoulos,Nikolaos, AU - Kanellopoulou,Dimitra, AU - Andriotis,Eleftherios G, AU - Tsibouklis,John, AU - Fatouros,Dimitrios G, Y1 - 2020/07/01/ PY - 2020/7/1/pubmed PY - 2020/7/1/medline PY - 2020/6/30/entrez KW - 2D printing KW - 3D printing KW - Inkjet printing KW - buccal delivery KW - fused deposition modeling KW - hydroxypropyl methylcellulose KW - mucoadhesion KW - mucoadhesive films KW - permeation SP - 1253 EP - 1264 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 46 IS - 8 N2 - OBJECTIVE: The inkjet printing (IP) and fused deposition modeling (FDM) technologies have emerged in the pharmaceutical field as novel and personalized formulation approaches. Specific manufacturing factors must be considered in each adopted methodology, i.e. the development of suitable substrates for IP and the incorporation of highly thermostable active pharmaceutical compounds (APIs) for FDM. In this study, IP and FDM printing technologies were investigated for the fabrication of hydroxypropyl methylcellulose-based mucoadhesive films for the buccal delivery of a thermolabile model drug. Significance: This proof-of-concept approach was expected to provide an alternative formulation methodology for personalized mucoadhesive buccal films. METHODS: Mucoadhesive substrates were prepared by FDM and were subjected to sequential IP of an ibuprofen-loaded liquid ink. The interactions between these processes and the performance of the films were evaluated by various analytical and spectroscopic techniques, as well as by in vitro and ex vivo studies. RESULTS: The model drug was efficiently deposited by sequential IP passes onto the FDM-printed substrates. Significant variations were revealed on the morphological, physicochemical and mechanical properties of the prepared films, and linked to the number of IP passes. The mechanism of drug release, the mucoadhesion and the permeation of the drug through the buccal epithelium were evaluated, in view of the extent of ink deposition onto the buccal films, as well as the distribution of the API. CONCLUSIONS: The presented methodology provided a proof-of-concept formulation approach for the development of personalized mucoadhesive films. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/32597338/Inkjet_printing_of_a_thermolabile_model_drug_onto_FDM-printed_substrates:_formulation_and_evaluation L2 - http://www.tandfonline.com/doi/full/10.1080/03639045.2020.1788062 DB - PRIME DP - Unbound Medicine ER -
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