Tags

Type your tag names separated by a space and hit enter

Acupuncture in the treatment of acute toxicity during and after head and neck cancer radiotherapy: Interim analysis of randomized prospective open-label trial.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020 Jun 18 [Online ahead of print]BP

Abstract

AIMS

The aim of this investigator-initiated prospective randomized open-label single institutional trial is to evaluate the role of acupuncture in the treatment of acute skin and mucosal toxicity, xerostomia, and perception of taste, pain, and nausea related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. This paper reports pilot data of the first 30 enrolled patients.

METHODS

Patients were randomized to undergo standard of care radiotherapy ± chemotherapy and support care defined by our institutional standard operating procedures alone or in the combination with acupuncture which was initiated with the first signs of any toxicity.

RESULTS

Fifteen patients were enrolled in both arms and all finished the treatment as planned.The median pain was significantly lower in the acupuncture arm (median 1.6 points vs. 2.5 points on a 10-item Likert scale; P=0.035) as well as duration of acute pain (median 31 days vs. 54 days; P=0.031). Patients with acupuncture had significantly shorter duration of acute skin (median 44 days vs. 109 days; P<0.001) and mucosal toxicity (median 34 days vs. 109 days; P<0.001) with no difference in grading of toxicity (median grade 1.6 vs. 1.5; P=0.701 and median grade 1.4 vs. 1.6; P=0.204 for skin and mucosa, respectively). No significant difference was found for other toxicity domains, with the exception of salivation toxicity which was significantly lower in acupuncture arm (median grade 1.3 vs. 1.7; P=0.048).

CONCLUSION

In this interim analysis, acupuncture leads to lower pain andfaster disappearance of skin and mucosal toxicity after (chemo)radiotherapy of head and neck cancer. Description and validation of acupuncture using scientific approaches will further enhance acceptance of this method by both patients and health care providers.

TRIAL REGISTRATION

Clinicaltrials.gov - NCT03751566.

Authors+Show Affiliations

Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.Regional Center for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32597419

Citation

Dymackova, Radana, et al. "Acupuncture in the Treatment of Acute Toxicity During and After Head and Neck Cancer Radiotherapy: Interim Analysis of Randomized Prospective Open-label Trial." Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2020.
Dymackova R, Kazda T, Slavik M, et al. Acupuncture in the treatment of acute toxicity during and after head and neck cancer radiotherapy: Interim analysis of randomized prospective open-label trial. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020.
Dymackova, R., Kazda, T., Slavik, M., Selingerova, I., Slampa, P., & Slama, O. (2020). Acupuncture in the treatment of acute toxicity during and after head and neck cancer radiotherapy: Interim analysis of randomized prospective open-label trial. Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. https://doi.org/10.5507/bp.2020.021
Dymackova R, et al. Acupuncture in the Treatment of Acute Toxicity During and After Head and Neck Cancer Radiotherapy: Interim Analysis of Randomized Prospective Open-label Trial. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020 Jun 18; PubMed PMID: 32597419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acupuncture in the treatment of acute toxicity during and after head and neck cancer radiotherapy: Interim analysis of randomized prospective open-label trial. AU - Dymackova,Radana, AU - Kazda,Tomas, AU - Slavik,Marek, AU - Selingerova,Iveta, AU - Slampa,Pavel, AU - Slama,Ondrej, Y1 - 2020/06/18/ PY - 2020/6/30/entrez JF - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia JO - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub N2 - AIMS: The aim of this investigator-initiated prospective randomized open-label single institutional trial is to evaluate the role of acupuncture in the treatment of acute skin and mucosal toxicity, xerostomia, and perception of taste, pain, and nausea related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. This paper reports pilot data of the first 30 enrolled patients. METHODS: Patients were randomized to undergo standard of care radiotherapy ± chemotherapy and support care defined by our institutional standard operating procedures alone or in the combination with acupuncture which was initiated with the first signs of any toxicity. RESULTS: Fifteen patients were enrolled in both arms and all finished the treatment as planned.The median pain was significantly lower in the acupuncture arm (median 1.6 points vs. 2.5 points on a 10-item Likert scale; P=0.035) as well as duration of acute pain (median 31 days vs. 54 days; P=0.031). Patients with acupuncture had significantly shorter duration of acute skin (median 44 days vs. 109 days; P<0.001) and mucosal toxicity (median 34 days vs. 109 days; P<0.001) with no difference in grading of toxicity (median grade 1.6 vs. 1.5; P=0.701 and median grade 1.4 vs. 1.6; P=0.204 for skin and mucosa, respectively). No significant difference was found for other toxicity domains, with the exception of salivation toxicity which was significantly lower in acupuncture arm (median grade 1.3 vs. 1.7; P=0.048). CONCLUSION: In this interim analysis, acupuncture leads to lower pain andfaster disappearance of skin and mucosal toxicity after (chemo)radiotherapy of head and neck cancer. Description and validation of acupuncture using scientific approaches will further enhance acceptance of this method by both patients and health care providers. TRIAL REGISTRATION: Clinicaltrials.gov - NCT03751566. SN - 1213-8118 UR - https://www.unboundmedicine.com/medline/citation/32597419/Acupuncture_in_the_treatment_of_acute_toxicity_during_and_after_head_and_neck_cancer_radiotherapy:_Interim_analysis_of_randomized_prospective_open-label_trial L2 - https://ClinicalTrials.gov/search/term=32597419 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.