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Nutrition in Pregnancy and Growth in Southwest China (NPGSC) cohort: Design, implementation, and characteristics.
Paediatr Perinat Epidemiol. 2020 Jun 29 [Online ahead of print]PP

Abstract

BACKGROUND

Pregnancy and birth cohorts addressing maternal nutrition and its impact on health outcomes have been rare in China, especially in Southwest China.

OBJECTIVES

To describe the design, implementation, baseline characteristics, and initial results of the Nutrition in Pregnancy and Growth in Southwest China (NPGSC) cohort.

POPULATION

Pregnant women with their children in Southwest China.

DESIGN

NPGSC participants have been prospectively recruited since 2014. Pregnant women were invited to participate in the study at their first routine ultrasound examination in gestational weeks 9-11. Data were assessed three times during pregnancy (9-11, 20-22, and 33-35 gestation weeks), and eight times in infants and toddlers.

METHODS

Pre-pregnancy body weight and height were self-reported; gestational weight gain was measured at regular intervals. Both food frequency questionnaires (FFQ) and 24-hour dietary recalls were used to collect dietary intakes during pregnancy, and FFQ for diet before pregnancy. Information on pregnancy outcomes was extracted from the medical birth registry. Anthropometry of children in the first 3 years of life was measured by trained investigators. Other child outcomes, including feeding practices (self-reported by mothers) and cognitive development (assessed by the Chinese version of Ages and Stages Questionnaire), were recorded.

PRELIMINARY RESULTS

Between 2014 and 2018, 12 989 pregnant women were enrolled, and 2296 children completed the 3 years follow-up. Among them, 115 pregnancies ended in stillbirth. Mean maternal pre-pregnancy BMI was 21.1 kg/m2 and mean gestational weight gain was 13.5 kg 18.6% of mothers developed gestational diabetes and 1.5% of mothers were diagnosed with preeclampsia. Mean birthweight and birth length of children were, respectively, 3329 g and 49.4 cm.

CONCLUSION

We built a prospective cohort in Southwest China, which can provide valuable data to investigate the relevance of nutrition for the health of mothers and children.

Authors+Show Affiliations

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.Nutrition, Consumption and Health, Faculty of Natural Sciences, University Paderborn, Paderborn, Germany.West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. Department of Clinical Nutrition, Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guiyang, China.Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. College of Public Health, Hebei University, Baoding, China.Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. Sichuan Provincial Centre for Disease Control and Prevention, Chengdu, China.Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.Department of Clinical Nutrition, Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guiyang, China.Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.Laboratory of Molecular Translational Medicine, Centre for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32597516

Citation

Zhang, Xiao, et al. "Nutrition in Pregnancy and Growth in Southwest China (NPGSC) Cohort: Design, Implementation, and Characteristics." Paediatric and Perinatal Epidemiology, 2020.
Zhang X, Gong Y, Chen Y, et al. Nutrition in Pregnancy and Growth in Southwest China (NPGSC) cohort: Design, implementation, and characteristics. Paediatr Perinat Epidemiol. 2020.
Zhang, X., Gong, Y., Chen, Y., Corte, K. D., Duan, R., Tian, G., Liang, Y., Xue, H., Zhang, J., Li, M., He, F., Yang, D., Zhou, R., & Cheng, G. (2020). Nutrition in Pregnancy and Growth in Southwest China (NPGSC) cohort: Design, implementation, and characteristics. Paediatric and Perinatal Epidemiology. https://doi.org/10.1111/ppe.12704
Zhang X, et al. Nutrition in Pregnancy and Growth in Southwest China (NPGSC) Cohort: Design, Implementation, and Characteristics. Paediatr Perinat Epidemiol. 2020 Jun 29; PubMed PMID: 32597516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrition in Pregnancy and Growth in Southwest China (NPGSC) cohort: Design, implementation, and characteristics. AU - Zhang,Xiao, AU - Gong,Yunhui, AU - Chen,Yue, AU - Corte,Karen Della, AU - Duan,Ruonan, AU - Tian,Guo, AU - Liang,Yi, AU - Xue,Hongmei, AU - Zhang,Jieyi, AU - Li,Ming, AU - He,Fang, AU - Yang,Dagang, AU - Zhou,Rong, AU - Cheng,Guo, Y1 - 2020/06/29/ PY - 2019/11/19/received PY - 2020/04/16/revised PY - 2020/05/18/accepted PY - 2020/6/30/entrez KW - NPGSC KW - cohort studies KW - infant health KW - nutrition surveys KW - pregnancy outcome JF - Paediatric and perinatal epidemiology JO - Paediatr Perinat Epidemiol N2 - BACKGROUND: Pregnancy and birth cohorts addressing maternal nutrition and its impact on health outcomes have been rare in China, especially in Southwest China. OBJECTIVES: To describe the design, implementation, baseline characteristics, and initial results of the Nutrition in Pregnancy and Growth in Southwest China (NPGSC) cohort. POPULATION: Pregnant women with their children in Southwest China. DESIGN: NPGSC participants have been prospectively recruited since 2014. Pregnant women were invited to participate in the study at their first routine ultrasound examination in gestational weeks 9-11. Data were assessed three times during pregnancy (9-11, 20-22, and 33-35 gestation weeks), and eight times in infants and toddlers. METHODS: Pre-pregnancy body weight and height were self-reported; gestational weight gain was measured at regular intervals. Both food frequency questionnaires (FFQ) and 24-hour dietary recalls were used to collect dietary intakes during pregnancy, and FFQ for diet before pregnancy. Information on pregnancy outcomes was extracted from the medical birth registry. Anthropometry of children in the first 3 years of life was measured by trained investigators. Other child outcomes, including feeding practices (self-reported by mothers) and cognitive development (assessed by the Chinese version of Ages and Stages Questionnaire), were recorded. PRELIMINARY RESULTS: Between 2014 and 2018, 12 989 pregnant women were enrolled, and 2296 children completed the 3 years follow-up. Among them, 115 pregnancies ended in stillbirth. Mean maternal pre-pregnancy BMI was 21.1 kg/m2 and mean gestational weight gain was 13.5 kg 18.6% of mothers developed gestational diabetes and 1.5% of mothers were diagnosed with preeclampsia. Mean birthweight and birth length of children were, respectively, 3329 g and 49.4 cm. CONCLUSION: We built a prospective cohort in Southwest China, which can provide valuable data to investigate the relevance of nutrition for the health of mothers and children. SN - 1365-3016 UR - https://www.unboundmedicine.com/medline/citation/32597516/Nutrition_in_Pregnancy_and_Growth_in_Southwest_China_(NPGSC)_cohort:_Design,_implementation,_and_characteristics L2 - https://doi.org/10.1111/ppe.12704 DB - PRIME DP - Unbound Medicine ER -
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