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[The relationship between the combined use of various proton pump inhibitors with antiplatelet drugs and the risk of cardiovascular complications].
Ter Arkh. 2019 Aug 15; 91(8):118-126.TA

Abstract

In the article the problem of the combined use of clopidogrel and various proton pump inhibitors (PPIs) in terms of cardiovascular complications risk and stent thrombosis is considered. The results of meta - analyses and a systematic reviews affecting this issue are represented in detail. The inter - drug interactions mechanisms of various PPIs with clopidogrel based on the characteristics of the metabolism in the liver cytochromes system are discussed. The authors conducted a search, systematization and analysis of studies regarding the association between cardiovascular risk and combined use of individual medications from PPI class with clopidogrel, and these results are presented in the review. Currently available data do not allow to answer the question about the differences between individual PPIs in their impact on the risk of adverse cardiovascular events due to the small number of such studies, design heterogeneity, differences in the inclusion criteria and end points as well as in the rate of administration of individual PPIs.

Authors+Show Affiliations

Pirogov Russian National Research Medical University - Russian Clinical and Research Center of Gerontology. Sechenov First Moscow State Medical University (Sechenov University).Pirogov Russian National Research Medical University - Russian Clinical and Research Center of Gerontology.Pirogov Russian National Research Medical University - Russian Clinical and Research Center of Gerontology.Yevdokimov Moscow State University of Medicine and Dentistry.Yevdokimov Moscow State University of Medicine and Dentistry.Yevdokimov Moscow State University of Medicine and Dentistry.Yevdokimov Moscow State University of Medicine and Dentistry.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

rus

PubMed ID

32598763

Citation

Ostroumova, O D., et al. "[The Relationship Between the Combined Use of Various Proton Pump Inhibitors With Antiplatelet Drugs and the Risk of Cardiovascular Complications]." Terapevticheskii Arkhiv, vol. 91, no. 8, 2019, pp. 118-126.
Ostroumova OD, Kochetkov AI, Pereverzev AP, et al. [The relationship between the combined use of various proton pump inhibitors with antiplatelet drugs and the risk of cardiovascular complications]. Ter Arkh. 2019;91(8):118-126.
Ostroumova, O. D., Kochetkov, A. I., Pereverzev, A. P., Kravchenko, E. V., Kazjulin, A. N., Andreev, D. N., & Pavleeva, E. E. (2019). [The relationship between the combined use of various proton pump inhibitors with antiplatelet drugs and the risk of cardiovascular complications]. Terapevticheskii Arkhiv, 91(8), 118-126. https://doi.org/10.26442/00403660.2019.08.000355
Ostroumova OD, et al. [The Relationship Between the Combined Use of Various Proton Pump Inhibitors With Antiplatelet Drugs and the Risk of Cardiovascular Complications]. Ter Arkh. 2019 Aug 15;91(8):118-126. PubMed PMID: 32598763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The relationship between the combined use of various proton pump inhibitors with antiplatelet drugs and the risk of cardiovascular complications]. AU - Ostroumova,O D, AU - Kochetkov,A I, AU - Pereverzev,A P, AU - Kravchenko,E V, AU - Kazjulin,A N, AU - Andreev,D N, AU - Pavleeva,E E, Y1 - 2019/08/15/ PY - 2020/04/16/received PY - 2020/6/30/entrez PY - 2020/7/1/pubmed PY - 2020/7/30/medline KW - adverse cardiovascular outcomes KW - coronary artery disease KW - drug interaction KW - dual antiplatelet therapy KW - percutaneous coronary intervention KW - proton pump inhibitor SP - 118 EP - 126 JF - Terapevticheskii arkhiv JO - Ter. Arkh. VL - 91 IS - 8 N2 - In the article the problem of the combined use of clopidogrel and various proton pump inhibitors (PPIs) in terms of cardiovascular complications risk and stent thrombosis is considered. The results of meta - analyses and a systematic reviews affecting this issue are represented in detail. The inter - drug interactions mechanisms of various PPIs with clopidogrel based on the characteristics of the metabolism in the liver cytochromes system are discussed. The authors conducted a search, systematization and analysis of studies regarding the association between cardiovascular risk and combined use of individual medications from PPI class with clopidogrel, and these results are presented in the review. Currently available data do not allow to answer the question about the differences between individual PPIs in their impact on the risk of adverse cardiovascular events due to the small number of such studies, design heterogeneity, differences in the inclusion criteria and end points as well as in the rate of administration of individual PPIs. SN - 0040-3660 UR - https://www.unboundmedicine.com/medline/citation/32598763/[The_relationship_between_the_combined_use_of_various_proton_pump_inhibitors_with_antiplatelet_drugs_and_the_risk_of_cardiovascular_complications] L2 - https://medlineplus.gov/bloodthinners.html DB - PRIME DP - Unbound Medicine ER -