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Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.
Int J Biol Macromol. 2020 Nov 15; 163:1-8.IJ

Abstract

The current pandemic of 2019 novel coronavirus disease (COVID-19) caused by a novel virus strain, 2019-nCoV/SARS-CoV-2 have posed a serious threat to global public health and economy. It is largely unknown how the human immune system responds to this infection. A better understanding of the immune response to SARS-CoV-2 will be important to develop therapeutics against COVID-19. Here, we have used transcriptomic profile of human alveolar adenocarcinoma cells (A549) infected with SARS-CoV-2 and employed a network biology approach to generate human-virus interactome. Network topological analysis discovers 15 SARS-CoV-2 targets, which belongs to a subset of interferon (IFN) stimulated genes (ISGs). These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19. We have identified significant interaction between ISGs and TLR3 agonists, like poly I: C, and imiquimod, and suggests that TLR3 agonists can be considered as a potential drug for drug repurposing in COVID-19. Our network centric analysis suggests that moderating the innate immune response is a valuable approach to target COVID-19.

Authors+Show Affiliations

Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, UP 201303, India.Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, UP 201303, India.Department of Pharmacology & Toxicology, College of Pharmacy Girls Section, Prince Sattam Bin AbdulAziz University, Al kharj 11942, Saudi Arabia.Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, UP 201303, India. Electronic address: vkumar33@amity.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32599245

Citation

Prasad, Kartikay, et al. "Targeting Hub Genes and Pathways of Innate Immune Response in COVID-19: a Network Biology Perspective." International Journal of Biological Macromolecules, vol. 163, 2020, pp. 1-8.
Prasad K, Khatoon F, Rashid S, et al. Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective. Int J Biol Macromol. 2020;163:1-8.
Prasad, K., Khatoon, F., Rashid, S., Ali, N., AlAsmari, A. F., Ahmed, M. Z., Alqahtani, A. S., Alqahtani, M. S., & Kumar, V. (2020). Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective. International Journal of Biological Macromolecules, 163, 1-8. https://doi.org/10.1016/j.ijbiomac.2020.06.228
Prasad K, et al. Targeting Hub Genes and Pathways of Innate Immune Response in COVID-19: a Network Biology Perspective. Int J Biol Macromol. 2020 Nov 15;163:1-8. PubMed PMID: 32599245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective. AU - Prasad,Kartikay, AU - Khatoon,Fatima, AU - Rashid,Summya, AU - Ali,Nemat, AU - AlAsmari,Abdullah F, AU - Ahmed,Mohammad Z, AU - Alqahtani,Ali S, AU - Alqahtani,Mohammed S, AU - Kumar,Vijay, Y1 - 2020/06/26/ PY - 2020/05/31/received PY - 2020/06/23/revised PY - 2020/06/24/accepted PY - 2020/7/1/pubmed PY - 2020/11/3/medline PY - 2020/6/30/entrez KW - COVID-19 KW - Drug repurposing KW - Immune response KW - Interferon stimulating genes KW - Network biology SP - 1 EP - 8 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 163 N2 - The current pandemic of 2019 novel coronavirus disease (COVID-19) caused by a novel virus strain, 2019-nCoV/SARS-CoV-2 have posed a serious threat to global public health and economy. It is largely unknown how the human immune system responds to this infection. A better understanding of the immune response to SARS-CoV-2 will be important to develop therapeutics against COVID-19. Here, we have used transcriptomic profile of human alveolar adenocarcinoma cells (A549) infected with SARS-CoV-2 and employed a network biology approach to generate human-virus interactome. Network topological analysis discovers 15 SARS-CoV-2 targets, which belongs to a subset of interferon (IFN) stimulated genes (ISGs). These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19. We have identified significant interaction between ISGs and TLR3 agonists, like poly I: C, and imiquimod, and suggests that TLR3 agonists can be considered as a potential drug for drug repurposing in COVID-19. Our network centric analysis suggests that moderating the innate immune response is a valuable approach to target COVID-19. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/32599245/Targeting_hub_genes_and_pathways_of_innate_immune_response_in_COVID_19:_A_network_biology_perspective_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(20)33683-7 DB - PRIME DP - Unbound Medicine ER -