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A cell in hand is worth two in the embryo: recent advances in 2-cell like cell reprogramming.
Curr Opin Genet Dev. 2020 Jun 26; 64:26-30.CO

Abstract

Multicellular organisms develop from a single cell, the zygote. This feature is referred to as totipotency. In the mouse, only the zygote and the 2-cell stage embryo display this attribute. Cells resembling the embryonic 2-cell stage blastomeres were identified in embryonic stem (ES) cell cultures as '2-cell-like cells' (2CLCs). This discovery brought the first cellular model with the possibility to investigate some features of the totipotent embryo and the molecular mechanisms regulating totipotency in vitro. In this article, we discuss the latest advancements on the research on 2CLCs, which have uncovered an intricate reprogramming process regulated by proteins as well as metabolites and ncRNAs. These recent findings have shed light on the combinatorial regulation of 2-cell-like cell emergence and the nature of their unique attributes.

Authors+Show Affiliations

Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, D-81377, München, Germany.Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, D-81377, München, Germany; Faculty of Biology, Ludwig-Maximilians Universität, München, Germany. Electronic address: torres-padilla@helmholtz-muenchen.de.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32599301

Citation

Iturbide, Ane, and Maria-Elena Torres-Padilla. "A Cell in Hand Is Worth Two in the Embryo: Recent Advances in 2-cell Like Cell Reprogramming." Current Opinion in Genetics & Development, vol. 64, 2020, pp. 26-30.
Iturbide A, Torres-Padilla ME. A cell in hand is worth two in the embryo: recent advances in 2-cell like cell reprogramming. Curr Opin Genet Dev. 2020;64:26-30.
Iturbide, A., & Torres-Padilla, M. E. (2020). A cell in hand is worth two in the embryo: recent advances in 2-cell like cell reprogramming. Current Opinion in Genetics & Development, 64, 26-30. https://doi.org/10.1016/j.gde.2020.05.038
Iturbide A, Torres-Padilla ME. A Cell in Hand Is Worth Two in the Embryo: Recent Advances in 2-cell Like Cell Reprogramming. Curr Opin Genet Dev. 2020 Jun 26;64:26-30. PubMed PMID: 32599301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cell in hand is worth two in the embryo: recent advances in 2-cell like cell reprogramming. AU - Iturbide,Ane, AU - Torres-Padilla,Maria-Elena, Y1 - 2020/06/26/ PY - 2020/05/13/received PY - 2020/05/28/accepted PY - 2020/7/1/pubmed PY - 2020/7/1/medline PY - 2020/6/30/entrez SP - 26 EP - 30 JF - Current opinion in genetics & development JO - Curr. Opin. Genet. Dev. VL - 64 N2 - Multicellular organisms develop from a single cell, the zygote. This feature is referred to as totipotency. In the mouse, only the zygote and the 2-cell stage embryo display this attribute. Cells resembling the embryonic 2-cell stage blastomeres were identified in embryonic stem (ES) cell cultures as '2-cell-like cells' (2CLCs). This discovery brought the first cellular model with the possibility to investigate some features of the totipotent embryo and the molecular mechanisms regulating totipotency in vitro. In this article, we discuss the latest advancements on the research on 2CLCs, which have uncovered an intricate reprogramming process regulated by proteins as well as metabolites and ncRNAs. These recent findings have shed light on the combinatorial regulation of 2-cell-like cell emergence and the nature of their unique attributes. SN - 1879-0380 UR - https://www.unboundmedicine.com/medline/citation/32599301/A_cell_in_hand_is_worth_two_in_the_embryo:_recent_advances_in_2-cell_like_cell_reprogramming L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-437X(20)30089-7 DB - PRIME DP - Unbound Medicine ER -
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