Tags

Type your tag names separated by a space and hit enter

Genome-Protecting Compounds as Potential Geroprotectors.
Int J Mol Sci. 2020 Jun 24; 21(12)IJ

Abstract

Throughout life, organisms are exposed to various exogenous and endogenous factors that cause DNA damages and somatic mutations provoking genomic instability. At a young age, compensatory mechanisms of genome protection are activated to prevent phenotypic and functional changes. However, the increasing stress and age-related deterioration in the functioning of these mechanisms result in damage accumulation, overcoming the functional threshold. This leads to aging and the development of age-related diseases. There are several ways to counteract these changes: 1) prevention of DNA damage through stimulation of antioxidant and detoxification systems, as well as transition metal chelation; 2) regulation of DNA methylation, chromatin structure, non-coding RNA activity and prevention of nuclear architecture alterations; 3) improving DNA damage response and repair; 4) selective removal of damaged non-functional and senescent cells. In the article, we have reviewed data about the effects of various trace elements, vitamins, polyphenols, terpenes, and other phytochemicals, as well as a number of synthetic pharmacological substances in these ways. Most of the compounds demonstrate the geroprotective potential and increase the lifespan in model organisms. However, their genome-protecting effects are non-selective and often are conditioned by hormesis. Consequently, the development of selective drugs targeting genome protection is an advanced direction.

Authors+Show Affiliations

Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya st., 167982 Syktyvkar, Russia.Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya st., 167982 Syktyvkar, Russia.Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya st., 167982 Syktyvkar, Russia. Pitirim Sorokin Syktyvkar State University, 55 Oktyabrsky prosp., 167001 Syktyvkar, Russia. Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32599754

Citation

Proshkina, Ekaterina, et al. "Genome-Protecting Compounds as Potential Geroprotectors." International Journal of Molecular Sciences, vol. 21, no. 12, 2020.
Proshkina E, Shaposhnikov M, Moskalev A. Genome-Protecting Compounds as Potential Geroprotectors. Int J Mol Sci. 2020;21(12).
Proshkina, E., Shaposhnikov, M., & Moskalev, A. (2020). Genome-Protecting Compounds as Potential Geroprotectors. International Journal of Molecular Sciences, 21(12). https://doi.org/10.3390/ijms21124484
Proshkina E, Shaposhnikov M, Moskalev A. Genome-Protecting Compounds as Potential Geroprotectors. Int J Mol Sci. 2020 Jun 24;21(12) PubMed PMID: 32599754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genome-Protecting Compounds as Potential Geroprotectors. AU - Proshkina,Ekaterina, AU - Shaposhnikov,Mikhail, AU - Moskalev,Alexey, Y1 - 2020/06/24/ PY - 2020/05/31/received PY - 2020/06/18/revised PY - 2020/06/19/accepted PY - 2020/7/1/entrez PY - 2020/7/1/pubmed PY - 2020/7/1/medline KW - DNA repair activators KW - aging KW - antioxidants KW - epidrugs KW - genomic protection KW - geroprotectors KW - senolytics KW - senomorphics JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 12 N2 - Throughout life, organisms are exposed to various exogenous and endogenous factors that cause DNA damages and somatic mutations provoking genomic instability. At a young age, compensatory mechanisms of genome protection are activated to prevent phenotypic and functional changes. However, the increasing stress and age-related deterioration in the functioning of these mechanisms result in damage accumulation, overcoming the functional threshold. This leads to aging and the development of age-related diseases. There are several ways to counteract these changes: 1) prevention of DNA damage through stimulation of antioxidant and detoxification systems, as well as transition metal chelation; 2) regulation of DNA methylation, chromatin structure, non-coding RNA activity and prevention of nuclear architecture alterations; 3) improving DNA damage response and repair; 4) selective removal of damaged non-functional and senescent cells. In the article, we have reviewed data about the effects of various trace elements, vitamins, polyphenols, terpenes, and other phytochemicals, as well as a number of synthetic pharmacological substances in these ways. Most of the compounds demonstrate the geroprotective potential and increase the lifespan in model organisms. However, their genome-protecting effects are non-selective and often are conditioned by hormesis. Consequently, the development of selective drugs targeting genome protection is an advanced direction. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32599754/Genome-Protecting_Compounds_as_Potential_Geroprotectors L2 - https://www.mdpi.com/resolver?pii=ijms21124484 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.